Laura McCulloch

Immunosenescence and its impact on ischemic stroke risk and outcomes in older adults: a systematic review

C. Seah, Matthias Ho, Collin S. Chu, Karishma Sachaphibulkij et autres

Background: Age is a major risk factor for ischemic stroke (IS), with immunosenescence-age-related immune system dysfunction - contributing to worse outcomes. Immunosenescence impairs immune responses, heightens inflammation, and increases susceptibility to infections, all of which affect stroke prognosis. This review investigates the …

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Dynamic changes to the intestinal environment occur throughout recovery from experimental ischemic stroke

R. Martin, Isobel C. Mouat, Robert K. Whelan, Lizi M. Hegarty et autres

Stroke survivors can experience a plethora of complications throughout their recovery that impair quality of life and impact neurological outcomes. Intestinal dysfunction is reported to occur rapidly following stroke in both humans and animal models and alterations such as reduced barrier integrity, …

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Acute ischaemic stroke alters the composition and function of circulating B cells

Mehwish Younas, Harry R. Deijnen, Ruth Stephens, Alison Harris et autres

• Acutely after stroke, circulating MZ-like B cells (an important source of early pathogen protective IgM) are substantially reduced in frequency, in comparison to non-stroke controls. • B cells show altered innate-like functionality, with reduced capacity to upregulate immunoglobulin M and cytokine …

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Cerebral ischaemic stroke results in altered mucosal antibody responses and host-commensal microbiota interactions

Madeleine Hurry, David A Posner, Raymond Wong, Alba Grayston et autres

Stroke is a devastating neurological event with a high risk of mortality that results in long-term sequalae that extend beyond the central nervous system. Notably these include gastrointestinal dysfunction and altered composition of the commensal microbiota in both patients and mouse models, …

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DYNAMIC CHANGES TO THE INTESTINAL ENVIRONMENT OCCUR THROUGHOUT RECOVERY FROM EXPERIMENTAL ISCHAEMIC STROKE

R. Martin, Isobel C. Mouat, Robert K. Whelan, Lizi M. Hegarty et autres

ABSTRACT Stroke survivors experience a plethora of complications during recovery, including gastrointestinal symptoms. Intestinal dysfunction is reported to occur rapidly following stroke in both humans and animal models and alterations such as reduced barrier integrity, lymphocyte loss, and an altered microbiota have …

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The Role of the VWF/ADAMTS13 Axis in the Thromboinflammatory Response in Ischemic Stroke After SARS‐CoV2 Infection

Nadim Luka, Kieron South, Rachel Jones, Amanda J. Unsworth et autres

BACKGROUND: SARS-CoV2 infections increase the risk of ischemic stroke (IS), potentially through a thromboinflammatory cascade driven by an imbalance in the ratio of Von Willebrand Factor (VWF) and a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13), leading …

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CSF1R inhibition by PLX5622 reduces pulmonary fungal infection by depleting MHCIIhi interstitial lung macrophages

Sally H. Mohamed, Eliane Vanhoffelen, Man Shun Fu, Pui Hei Lau et autres

PLX5622 is a small molecular inhibitor of the CSF1 receptor (CSF1R) and is widely used to deplete macrophages within the central nervous system (CNS). We investigated the impact of PLX5622 treatment in wild-type C57BL/6 mice and discovered that one-week treatment with PLX5622 …

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Evidence of aberrant anti-epstein-barr virus antibody response, though no viral reactivation, in people with post-stroke fatigue

Isobel C. Mouat, Li Zhu, Alperen Aslan, Barry W. McColl et autres

Abstract Background Fatigue is a common complication of stroke that has a significant impact on quality of life. The biological mechanisms that underly post-stroke fatigue are currently unclear, however, reactivation of latent viruses and their impact on systemic immune function have been …

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6433 The golden hour for sepsis in a district general hospital – how do we perform and how can our MDT help us improve?

Lindsey McVey, Laura McCulloch, Beatrice Milligan, Jacqueline Welsh et autres

Objectives Sepsis kills 2.9 million children under five years old globally each year, and five people every hour in the UK.1 2 Early recognition and intervention are crucial, with evidence suggesting a target should be set for administering antibiotics within one hour.3 …

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Evidence of aberrant anti-Epstein-Barr virus antibody response, though no viral reactivation, in people with post-stroke fatigue

Isobel C. Mouat, Li Zhu, Alperen Aslan, Barry W. McColl et autres

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Evidence of aberrant anti-Epstein-Barr virus antibody response, though no viral reactivation, in people with post-stroke fatigue

Isobel C. Mouat, Judy Zhu, Alperen Aslan, Barry W. McColl et autres

Abstract BACKGROUND Fatigue is a common complication of stroke that has a significant impact on quality of life. The biological mechanisms that underly post-stroke fatigue are currently unclear, however, reactivation of latent viruses and their impact on systemic immune function have been …

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Cystatin F (Cst7) drives sex-dependent changes in microglia in an amyloid-driven model of Alzheimer’s disease

Michael J. Daniels, Lucas Lefèvre, Stefan Szymkowiak, Alice Drake et autres

Microglial endolysosomal (dys)function is strongly implicated in neurodegenerative disease. Transcriptomic studies show that a microglial state characterised by a set of genes involved in endolysosomal function is induced in both mouse Alzheimer’s disease (AD) models and human AD brain, and that the …

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