Bingtao Zhai

Research Progress on Self-Assembling Delivery Systems in Rheumatoid Arthritis

Ling-Ling Yu, Tian-tian Wei, Xie-yu Zhang, Jiangxue Cheng et autres

Rheumatoid arthritis (RA)-affected joints are characterized by a distinct pathological microenvironment, featuring acidic pH, elevated reactive oxygen species (ROS), and overexpressed matrix metalloproteinases (MMPs), along with synovial hyperplasia, infiltration of activated immune cells (eg, M1 macrophages and Th17 cells), and pannus formation. …

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The integration of network pharmacology and multiomics reveals the mechanism by which Malus hupehensis leaves inhibit acute liver injury

Jia-Xin Qiao, Shu‐Jie Lv, Bingtao Zhai, Xi Zhang et autres

OBJECTIVE: The leaves of Malus hupehensis (MH) are a medicinal and edible TCM with good liver protection, although its underlying mechanism remains unclear. In this study, a network pharmacology-integrated multiomics method was used to explore the hepatoprotective mechanism of MH. METHODS: The …

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Multi-Technology Empowers Dissolving Microneedles: A Novel Strategy in Rheumatoid Arthritis

Tiantian Wei, Yu-meng Song, Bingtao Zhai, Jia-Xin Qiao et autres

Rheumatoid arthritis (RA) is a systemic autoimmune disease associated with chronic inflammation. Current clinical management is confronted with multiple challenges, such as suboptimal drug bioavailability, insufficient joint targeting, and poor patient compliance, which critically limit therapeutic efficacy. Dissolving microneedles (DMNs) can overcome …

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An Injectable Photothermal Responsive Liposome Hydrogel Co-Loaded with Bufalin, Apatinib, and IR820 for Inhibiting Postoperative Recurrence of Colon Cancer

Ai-Jia Wang, Huan Tian, Zhan-Peng Wang, Jiangxue Cheng et autres

Background: Colon cancer ranks as the third most common malignant tumor globally. Due to incomplete surgical resection and the multidrug resistance of tumor cells, it exhibits a high postoperative recurrence rate. Consequently, there is an urgent need to develop novel therapeutic strategies …

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Multi-omics integration reveals that KLF improves stomach heat syndrome through intestinal flora remodeling and PI3K-Akt pathway activation

Jia-Xin Qiao, Dan Zhang, Bingtao Zhai, Jiangxue Cheng et autres

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Research Progress of Docetaxel Nano-Drug Delivery System in the Treatment of Breast Cancer

Rong Zhang, Bingtao Zhai, Jia-Xin Qiao, Dan Zhang et autres

Breast cancer (BC) is the most common malignant tumor in women. Docetaxel (DTX), a chemotherapeutic agent derived from paclitaxel (PTX), has received approval from the US Food and Drug Administration (FDA) for the treatment of BC and various other malignancies. Nevertheless, its …

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Deciphering the molecular mechanisms underlying of Xin Xue Granule on LPS-induced pyrexia rats: A multi-omics analysis

Kaixuan Zhang, Yajun Shi, Xiaofei Zhang, Bingtao Zhai et autres

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Exploring the mechanisms of Jintiange capsules in OA treatment through miRNA-214-3p modulation in SMSC-Exos

Zhichao Wang, Fei Luan, Ya-Jun Shi, Xiaofei Zhang et autres

Integrated analyses of metabolomics, transcriptomics, and network pharmacology reveal the effect of Shuangshi Tonglin Capsule against cervicitis in rats

Bo Han, Fei Luan, Xiaofei Zhang, Dongyan Guo et autres

Study on the underlying mechanism of Qianghuo Shengshi Decoction in the treatment of wind-cold-dampness arthralgia type rheumatoid arthritis by integrating systems biology, transcriptomics and experimental validation

Huan Tian, Qing-Rui Qi, Feng Zhao, Qiang-Qiang Fan et autres

The study on the effects of Paeoniae Radix Rubra – Angelicae Sinensis Radix before and after compatibility on energy metabolism in cold and heat syndrome model rats

Shihao Zhang, Jing Sun, Xiaofei Zhang, Fei Luan et autres

Modified particles-stabilized pickering emulsion to improve the thermal stability of volatile oil: A Lingzhu pulvis case study

Zhichao Wang, Junbo Zou, Yajun Shi, Fei Luan et autres

Background Essential oils have significant pharmacological activities but poor stability, especially thermal stability, and they tend to decompose and lose their pharmacological activities. Based on the concept of “combination of medicine and adjuvant” introduces particle design technology and Pickering emulsion technology. Using …

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