Zizhen Gong

Multi-omics analyses unveil gut microbiota and metabolites signatures in deoxycholic acid-associated intestinal inflammation

Gaojie Zhang, Ye Huang, Zizhen Gong, Congfeng Xu et autres

Objective High-fat diet (HFD) is closely related to the increased incidence of inflammatory bowel disease (IBD), and excessive fecal deoxycholic acid (DCA) induced by HFD makes significant contribution to the colonic inflammation. However, the precise mechanisms remain unclear. This study aims to …

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Analysis of homocysteine levels in carriers with MMACHC gene variants

Yi Ding, Yuxin Deng, 支海娟, Xia Zhan et autres

OBJECTIVE: Variants in the MMACHC gene cause combined methylmalonic acidemia (MMA) and homocystinuria, cobalamin C (cblC) type. This study aimed to determine whether heterozygous MMACHC variant carriers exhibit elevated plasma homocysteine (Hcy) levels and to explore the variant-type-specific biochemical effects. METHODS: In …

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Supplementary Figure 1 from DAZAP1 Phase Separation Regulates Mitochondrial Metabolism to Facilitate Invasion and Metastasis of Oral Squamous Cell Carcinoma

Jiayi Zhang, Zihui Ni, Yu Zhang, Yan Guo et autres

DAZAP1 promotes OSCC cell migration, invasion and EMT progression.

Supplementary Figure 2 from DAZAP1 Phase Separation Regulates Mitochondrial Metabolism to Facilitate Invasion and Metastasis of Oral Squamous Cell Carcinoma

Jiayi Zhang, Zihui Ni, Yu Zhang, Yan Guo et autres

Oxygen consumption rate (OCR) and Extracellular acidification rate (ECAR) analysis in DAZAP1-overexpression and -knockdown Cal27 and HN6 cell lines.

Supplementary Figure 4 from DAZAP1 Phase Separation Regulates Mitochondrial Metabolism to Facilitate Invasion and Metastasis of Oral Squamous Cell Carcinoma

Jiayi Zhang, Zihui Ni, Yu Zhang, Yan Guo et autres

COX16 enhances invasion and mitochondrial respiration in OSCC cells.

Supplementary Figure 9 from DAZAP1 Phase Separation Regulates Mitochondrial Metabolism to Facilitate Invasion and Metastasis of Oral Squamous Cell Carcinoma

Jiayi Zhang, Zihui Ni, Yu Zhang, Yan Guo et autres

Targeting DAZAP1 suppresses tumor growth and metastasis in OSCC.

Supplementary Figure 6 from DAZAP1 Phase Separation Regulates Mitochondrial Metabolism to Facilitate Invasion and Metastasis of Oral Squamous Cell Carcinoma

Jiayi Zhang, Zihui Ni, Yu Zhang, Yan Guo et autres

CYTOR promotes DAZAP1 nuclear translocation and phase separation.

Supplementary Figure 3 from DAZAP1 Phase Separation Regulates Mitochondrial Metabolism to Facilitate Invasion and Metastasis of Oral Squamous Cell Carcinoma

Jiayi Zhang, Zihui Ni, Yu Zhang, Yan Guo et autres

Alternative splicing of COX16 in OSCC cells.

Supplementary Figure 7 from DAZAP1 Phase Separation Regulates Mitochondrial Metabolism to Facilitate Invasion and Metastasis of Oral Squamous Cell Carcinoma

Jiayi Zhang, Zihui Ni, Yu Zhang, Yan Guo et autres

DAZAP1 promotes OSCC progression via phase separation.

Supplementary Figure 5 from DAZAP1 Phase Separation Regulates Mitochondrial Metabolism to Facilitate Invasion and Metastasis of Oral Squamous Cell Carcinoma

Jiayi Zhang, Zihui Ni, Yu Zhang, Yan Guo et autres

The COX16 overexpression rescues the DAZAP1-knockdown induced phenotypes of OSCC cell lines.

Supplementary Figure 8 from DAZAP1 Phase Separation Regulates Mitochondrial Metabolism to Facilitate Invasion and Metastasis of Oral Squamous Cell Carcinoma

Jiayi Zhang, Zihui Ni, Yu Zhang, Yan Guo et autres

Detection of Dazap1 knockdown efficiency in 4MOSC2 cells after transduced by Tet-on lentivirus.

Lactate‐induced metabolic reprogramming of TAMs impairs antigen presentation capacity via C/EBPα–CD74 axis in oral squamous cell carcinoma

Mengyao Wang, Mengqi Wang, Zizhen Gong, Fanrui Zeng et autres

BACKGROUND: Throughout oral squamous cell carcinoma (OSCC) progression, tumor-associated macrophages (TAMs) lose their antigen-presenting capacity and anti-tumor function. The mechanisms that cause this dysfunction are not fully understood. CD74 is essential for antigen-presenting process, while little direct evidence describes its role in …

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