Ai‐Ming Wong

The Impact of Weight Loss on the Physiological Endotypes Associated With OSA

Caroline Beatty, Ai‐Ming Wong, Shane A. Landry, Luke D. J. Thomson et autres

Background Weight loss improves upper airway collapsibility in people with OSA. However, it is unclear how weight loss affects the other physiological traits (ie, endotypes) associated with OSA (loop gain, arousal threshold, and muscle compensation). Research Questions What is the effect of …

au, us (code pays fourni par la source)

O057 The Impact of Surgical Weight Loss on the Physiological Endotypes causing Obstructive Sleep Apnea

Caroline Beatty, Ai‐Ming Wong, Shane A. Landry, Luke D. J. Thomson et autres

Abstract Background Weight loss improves upper airway collapsibility in people with obstructive sleep apnoea (OSA). However, it’s unclear how weight loss affects the other endotypes responsible for OSA (loop gain, arousal threshold and muscle compensation). We investigated the effect surgical weight loss …

au, us (code pays fourni par la source)

A review of supine position related obstructive sleep apnea: Classification, epidemiology, pathogenesis and treatment

Shane A. Landry, Caroline Beatty, Luke D. J. Thomson, Ai‐Ming Wong et autres

Supine related obstructive sleep apnea (OSA) is the most common clinical and physiological phenotype of OSA. This condition is recognizable by patients, their families and through polysomnographic recordings. Commonly used definitions distinguish the presence of supine related OSA when respiratory events occur …

au (code pays fourni par la source)

A single dose of noradrenergic/serotonergic reuptake inhibitors combined with an antimuscarinic does not improve obstructive sleep apnoea severity

Luke D. J. Thomson, Shane A. Landry, Simon A. Joosten, D Mann et autres

Previous trials have demonstrated that the combination of noradrenergic reuptake inhibitors with an antimuscarinic can substantially reduce the apnoea-hypopnoea index (AHI) and improve airway collapsibility in patients with obstructive sleep apnoea (OSA). However, some studies have shown that when administered individually, neither …

us, au (code pays fourni par la source)

Examining the impact of multilevel upper airway surgery on the obstructive sleep apnoea endotypes and their utility in predicting surgical outcomes

Ai‐Ming Wong, Shane A. Landry, Simon A. Joosten, Luke D. J. Thomson et autres

Abstract Background and objective Upper airway surgery for obstructive sleep apnoea (OSA) is an alternative treatment for patients who are intolerant of continuous positive airway pressure (CPAP). However, upper airway surgery has variable treatment efficacy with no reliable predictors of response. While …

au, us (code pays fourni par la source)

O023 Impact of weight loss of OSA pathophysiology

Ai‐Ming Wong, Shane A. Landry, K. J. Yang, Simon A. Joosten et autres

Abstract Introduction Obesity is a major risk factor for developing obstructive sleep apnoea (OSA), however, the underlying mechanisms are not fully understood. We aimed to assess the impact of weight loss on all OSA endotypes (i.e. upper airway collapsibility, muscle compensation, respiratory …

au, us (code pays fourni par la source)

Considering the Role of Adherence in New and Emerging Sleep Treatments

Simon A. Joosten, Shane A. Landry, Ai‐Ming Wong, Bradley A. Edwards

au (code pays fourni par la source)

Assessing the Physiologic Endotypes Responsible for REM- and NREM-Based OSA

Simon A. Joosten, Shane A. Landry, Ai‐Ming Wong, D Mann et autres

au, us (code pays fourni par la source)

Dietary intake, eating behavior and physical activity in individuals with and without obstructive sleep apnea

Caroline Beatty, Shane A. Landry, Joy Li-Yueh Lee, Simon A. Joosten et autres

au (code pays fourni par la source)

A randomized controlled trial of oxygen therapy for patients who do not respond to upper airway surgery for obstructive sleep apnea

Simon A. Joosten, Michael C. Y. Tan, Ai‐Ming Wong, Shane A. Landry et autres

au, us (code pays fourni par la source)

The Effect of Hypopnea Scoring on the Arousal Threshold in Patients with Obstructive Sleep Apnea

Luke D. J. Thomson, Shane A. Landry, Rebecca Singleton, Ai‐Ming Wong et autres

Excluding n = 20 that no longer had OSA (defined as an apnea-hypopnea index ,5/h) using the AASM 2012 Acceptable criteria.

au, us (code pays fourni par la source)

Understanding the impact of weight loss and upper airway surgery on the physiological causes of obstructive sleep apnoea - A pathway to personalised sleep medicine

Ai‐Ming Wong

Weight loss via bariatric surgery and upper airway surgery are effective alternative treatments for obstructive sleep apnoea, however, current clinical tools cannot accurately predict treatment response. Therefore, this thesis examines how these two interventions affect the underlying physiology causing sleep apnoea. This …