Paulina Kucharzewska

Migrasomes in cancers: from the biogenesis mechanism to therapeutic implications

Luomeng Qian, Shoujun Wang, Paulina Kucharzewska, Jiachang Li et autres

Migrasomes are a newly identified class of extracellular vesicles (EVs) with a distinctive pomegranate-like morphology that are generated specifically from migrating cells. They are increasingly recognized as critically important mediators of intercellular communication involved in diverse physiological and pathological processes. However, their …

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Corrigendum to “The protective effect of silver nanoparticles' on epithelial cornea cells against ultraviolet is accompanied by changes in calcium homeostasis and a decrease of the P2X7 and P2Y2 receptors” [Biomed. Pharmacother. 174 (2024) 116090]

Patryk Krzemiński, Irena Misiewicz-Krzemińska, Marta Grodzik, IRENA PADZIŃSKA-PRUSZYŃSKA et autres

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Graphene-Based Nanosystem for Targeted Delivery of Anti-Sense miRNA-21 on Hepatocellular Carcinoma Cells

Paola Trischitta, Paulina Kucharzewska, Barbara Nasiłowska, Wojciech Skrzeczanowski et autres

The application of nanotechnology in medicine has garnered significant interest, particularly in the development of advanced drug delivery systems. Graphene oxide (GO) shows promise as a carrier for delivering microRNA (miRNA) mimics or antisense constructs. miRNAs play a crucial role in regulating …

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Lysophosphatidic acid-induced Arf6-driven macropinocytosis of CD147 + extracellular vesicles promotes sorafenib resistance of hepatocellular carcinoma

Luomeng Qian, Zhiguang Fu, Ping Chen, Yuan Guo et autres

: Our findings uncover a previously unrecognized mechanism mediated by differential TME and CD147⁺ EV macropinocytosis in HCC and highlight the LPA-Arf6-macropinocytosis as a novel targeting axis to overcome SFR in HCC.

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Emerging macrophage-based therapies for cancer: a review of preclinical and clinical advances

Jan Brancewicz, Paulina Kucharzewska

Macrophages, the most abundant immune cells in many solid tumors, are no longer viewed solely as accomplices of cancer but as powerful therapeutic allies. This review charts the rapid rise of macrophage-based immunotherapies, from CD47/SIRPα checkpoint blockade and CAR-macrophages to macrophage-drug conjugates …

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Immunotherapy for Platinum-Resistant Ovarian Cancer as a Glimmer of Hope

Jan Brancewicz, Irena Barbara Padzińska-Pruszyńska, Małgorzata Kubiak, Paulina Kucharzewska

Ovarian cancer is a leading cause of cancer-related deaths among women, with platinum resistance posing a significant challenge. Conventional therapies often fail in these cases, highlighting the urgent need for novel treatment approaches. Immunotherapy has emerged as a promising strategy, offering renewed …

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Adoptive cell therapy with macrophage-drug conjugates facilitates cytotoxic drug transfer and immune activation in glioblastoma models

Miaomiao Sun, Maciej Białasek, Maud Mayoux, Meng-Syuan Lin et autres

The treatment of solid tumors faces substantial hurdles because of inadequate drug delivery and the immunosuppressive tumor microenvironment. To address these challenges, we developed a therapeutic platform using macrophages loaded with ferritin-drug conjugates, referred to as macrophage-drug conjugates (MDC), and applied it …

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Adoptive cell therapy with macrophage-drug conjugates facilitates cytotoxic drug transfer and immune activation in glioblastoma models

Miaomiao Sun, Maciej Białasek, Maud Mayoux, Meng-Syuan Lin et autres

The treatment of solid tumors faces substantial hurdles because of inadequate drug delivery and the immunosuppressive tumor microenvironment. To address these challenges, we developed a therapeutic platform using macrophages loaded with ferritin-drug conjugates, referred to as macrophage-drug conjugates (MDC), and applied it …

27-Hydroxycholesterol in cancer development and drug resistance

Yaxin Hou, Zhiguang Fu, Chenhui Wang, Paulina Kucharzewska et autres

27-Hydroxycholesterol (27HC), a cholesterol metabolite, functions both as a selective oestrogen receptor (ER) modulator and a ligand for liver X receptors (LXRs). The discovery of 27HC involvement in carcinogenesis has unveiled new research avenues, yet its precise role remains controversial and context-dependent. …

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Harnessing macrophage-drug conjugates for allogeneic cell-based therapy of solid tumors via the TRAIN mechanism

Bartłomiej Taciak, Maciej Białasek, Małgorzata Kubiak, Ilona Marszałek et autres

Treatment of solid tumors remains challenging and therapeutic strategies require continuous development. Tumor-infiltrating macrophages play a pivotal role in tumor dynamics. Here, we present a Macrophage-Drug Conjugate (MDC) platform technology that enables loading macrophages with ferritin-drug complexes. We first show that macrophages …

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Targeting Cancer: Microenvironment and Immunotherapy Innovations

Irena Barbara Padzińska-Pruszyńska, Bartłomiej Taciak, Łukasz Kiraga, Anna Smolarska et autres

In 2024, the United States was projected to experience 2 million new cancer diagnoses and approximately 611,720 cancer-related deaths, reflecting a broader global trend in which cancer cases are anticipated to exceed 35 million by 2050. This increasing burden highlights ongoing challenges …

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Macrophages: Key Players in the Battle against Triple-Negative Breast Cancer

Irena Barbara Padzińska-Pruszyńska, Paulina Kucharzewska, Agata Matejuk, Małgorzata Górczak et autres

Triple-negative breast cancer (TNBC) is a challenging subtype of breast cancer characterized by the absence of estrogen and progesterone receptors and HER2 expression, leading to limited treatment options and a poorer prognosis. TNBC is particularly prevalent in premenopausal African-descent women and is …

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