Profil bibliographique

Charlotte Butterworth

Informations fournies par OpenAlex. Research Africa ne déduit ni nationalité, ni poste, ni coordonnées personnelles.

19Publications signalées
133Citations signalées
1Affiliations récentes

Les institutions déclarées

Institut Curie

Les domaines associés

Neuroblastoma Research and TreatmentsGlioma Diagnosis and TreatmentCancer, Hypoxia, and MetabolismImmune cells in cancerCancer Treatment and Pharmacology

Les publications récentes

Accès ouvert 2025 preprint OpenAlex

KDM5-driven transcriptional noise fuels plasticity-led awakening and relapse in paediatric cancer

Alejandro Allo Anido, Cecilia Roux, Emilia Chen, Siân Hamer et autres

How drug-tolerant persister (DTP) cells escape quiescence to drive tumour relapse is a central unresolved question in cancer evolution. Here, we identify transcriptional noise (TN), defined as the stochastic variability in gene expression, as a latent property of paediatric cancer cells that …

ca, fr, gb (code pays fourni par la source)

0 citations bioRxiv (Cold Spring Harbor Laboratory)
2024 conference-abstract OpenAlex

Abstract B074: Clonal decomposition and DNA replication states defined by scaled single-cell DNA and RNA sequencing suggest clone-specific therapeutic vulnerabilities in neuroblastoma

Jaydutt Digambar Bhalshankar, Angela Bellini, Irène Jiménez, Cécile Thirant et autres

Abstract Background: In neuroblastoma (NB), intratumor heterogeneity (ITH) is frequently observed, but the role of cell-to-cell allele-specific copy number alterations in phenotypic variation, clonal evolution and treatment response remains to be determined. Here we investigate ITH, timing of specific genomic aberrations, single-cell …

fr, es (code pays fourni par la source)

0 citations Cancer Research
Accès ouvert 2024 other OpenAlex

Data from Sequential Analysis of cfDNA Reveals Clonal Evolution in Patients with Neuroblastoma Receiving ALK-Targeted Therapy

Charles Bobin, Yasmine Iddir, Charlotte Butterworth, Julien Masliah‐Planchon et autres

AbstractPurpose: The study of cell-free DNA (cfDNA) enables sequential analysis of tumor cell–specific genetic alterations in patients with neuroblastoma. Experimental Design: Eighteen patients with relapsing neuroblastoma having received lorlatinib, a third-generation ALK inhibitor, were identified (SACHA national registry and/or in the institution). …

0 citations
Accès ouvert 2024 other OpenAlex

Data from Sequential Analysis of cfDNA Reveals Clonal Evolution in Patients with Neuroblastoma Receiving ALK-Targeted Therapy

Charles Bobin, Yasmine Iddir, Charlotte Butterworth, Julien Masliah‐Planchon et autres

AbstractPurpose: The study of cell-free DNA (cfDNA) enables sequential analysis of tumor cell–specific genetic alterations in patients with neuroblastoma. Experimental Design: Eighteen patients with relapsing neuroblastoma having received lorlatinib, a third-generation ALK inhibitor, were identified (SACHA national registry and/or in the institution). …

0 citations
Profil ORCIDNotice OpenAlex

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