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Joanna C. Porter, Jamie Inshaw, Vincente Joel Solis, Emma Denneny et autres
gb, de (code pays fourni par la source)
Joanna C. Porter, Jamie Inshaw, Vincente Joel Solis, Emma Denneny et autres
Background: Prinflammatory extracellular chromatin from neutrophil extracellular traps (NETs) and other cellular sources is found in COVID-19 patients and may promote pathology. We determined whether pulmonary administration of the endonuclease dornase alfa reduced systemic inflammation by clearing extracellular chromatin. Methods: Eligible patients …
gb, de, us (code pays fourni par la source)
Joanna C. Porter, Jamie Inshaw, Vincente Joel Solis, Emma Denneny et autres
Abstract Background Cell-free (cf)-DNA, from cellular sources, including Neutrophil Extracellular Traps (NETs), is found in the circulation of COVID-19 patients and may contribute to immune dysregulation. This study determined whether pulmonary administration of the endonuclease, dornase alfa, reduced systemic inflammation by degrading …
gb, de, us (code pays fourni par la source)
Joanna C. Porter, Jamie Inshaw, Vincente Joel Solis, Emma Denneny et autres
Cell-free (cf)-DNA, from cellular sources, including Neutrophil Extracellular Traps (NETs), is found in the circulation of COVID-19 patients and may contribute to immune dysregulation. This study determined whether pulmonary administration of the endonuclease, dornase alfa, reduced systemic inflammation by degrading local and …
gb, de, us (code pays fourni par la source)
Joanna C. Porter, Jamie Inshaw, Vincente Joel Solis, Emma Denneny et autres
Cell-free (cf)-DNA, from cellular sources, including Neutrophil Extracellular Traps (NETs), is found in the circulation of COVID-19 patients and may contribute to immune dysregulation. This study determined whether pulmonary administration of the endonuclease, dornase alfa, reduced systemic inflammation by degrading local and …
Joanna C. Porter, Jamie Inshaw, Vincente Joel Solis, Emma Denneny et autres
Abstract Background Cell-free (cf)-DNA, from cellular sources, including Neutrophil Extracellular Traps (NETs), is found in the circulation of COVID-19 patients and may contribute to immune dysregulation. This study determined whether pulmonary administration of the endonuclease, dornase alfa, reduced systemic inflammation by degrading …
gb, de, us (code pays fourni par la source)
Joanna C. Porter, Jamie Inshaw, Vincente Joel Solis, Emma Denneny et autres
Cell-free (cf)-DNA, from cellular sources, including Neutrophil Extracellular Traps (NETs), is found in the circulation of COVID-19 patients and may contribute to immune dysregulation. This study determined whether pulmonary administration of the endonuclease, dornase alfa, reduced systemic inflammation by degrading local and …
gb, de, us (code pays fourni par la source)
Joanna C. Porter, Jamie Inshaw, Vincente Joel Solis, Emma Denneny et autres
Background: Prinflammatory extracellular chromatin from neutrophil extracellular traps (NETs) and other cellular sources is found in COVID-19 patients and may promote pathology. We determined whether pulmonary administration of the endonuclease dornase alfa reduced systemic inflammation by clearing extracellular chromatin. Methods: Eligible patients …
gb, de, us (code pays fourni par la source)
Joanna C. Porter, Jamie Inshaw, Vincente Joel Solis, Emma Denneny et autres
Abstract Background SARS-CoV2 infection causes severe, life-threatening pneumonia. Hyper-inflammation, coagulopathy and lymphopenia are associated with pathology and poor outcomes in these patients. Cell-free (cf) DNA is prominent in COVID-19 patients, amplifies inflammation and promotes coagulopathy and immune dysfunction. We hypothesized that cf-DNA …
gb, us (code pays fourni par la source)
Iker Valle Aramburu, Dennis Hoving, Spyros I. Vernardis, Martha C.F. Tin et autres
The factors that influence survival during severe infection are unclear. Extracellular chromatin drives pathology, but the mechanisms enabling its accumulation remain elusive. Here, we show that in murine sepsis models, splenocyte death interferes with chromatin clearance through the release of the DNase …
gb, de, ch (code pays fourni par la source)
Μαριάννα Ιωάννου, Dennis Hoving, Iker Valle Aramburu, Mia I. Temkin et autres
Abstract The mechanisms linking systemic infection to hyperinflammation and immune dysfunction in sepsis are poorly understood. Extracellular histones promote sepsis pathology, but their source and mechanism of action remain unclear. Here, we show that by controlling fungi and bacteria captured by splenic …
gb, de, ch (code pays fourni par la source)
Joanna C. Porter, Jamie Inshaw, Vincente Joel Solis, Emma Denneny et autres
ABSTRACT Background Cell-free (cf)-DNA, from cellular sources, including Neutrophil Extracellular Traps (NETs), is found in the circulation of COVID-19 patients and may contribute to immune dysregulation. This study determined whether pulmonary administration of the endonuclease, dornase alfa, reduced systemic inflammation by degrading …
gb (code pays fourni par la source)
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