Maria Raquel Figueiredo

Phenotypic Analysis of the Anti-T. cruzi Activity of Natural Products Obtained from Brazilian Botanical Sources

Ludmila Ferreira de Almeida Fiuza, Denise da Gama Jaén Batista, Carolinna Silva Bressan, Marcos Meuser Batista et autres

Chagas disease, caused by Trypanosoma cruzi (T. cruzi), affects more than 6 million people worldwide, predominantly in Latin America. Current chemotherapy relies on Benznidazole (Bz) and Nifurtimox, which are associated with adverse effects and limited efficacy during chronic infection, underscoring the need …

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Larvicidal, oviposition inhibition, electrophysiological, histological, and docking activity of Eugenia uniflora L. oil against Aedes aegypti

João Vitor Castro Aguiar, Júlio César Ribeiro de Oliveira Farias de Aguiar, Edna Barbosa de Lima, Ana Carla da Silva et autres

Introduction Arboviruses represent a serious problem affecting half of the world’s population, according to the World Health Organization. Natural products are an option for combating this vector. Method The essential oil (EO) of E. uniflora was extracted by hydrodistillation, while the isolation …

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Application of preparative high-speed countercurrent chromatography for isolation of a bicyclo-[3.2.1]-octanoid neolignan from Piper multinodum C. DC. and determination of its absolute stereochemistry

André Mesquita Marques, Lavínia de Carvalho Brito, Ana Carolina Ferreira de Albuquerque, Agnes de Freitas Diniz de Souza et autres

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Joannesia princeps Vell. inhibits purinergic P2Y receptors and presents antinociceptive and anti-inflammatory effects

Natiele Carla da Silva Ferreira, Ana Luíza Rangel Bérenger, Maria Raquel Figueiredo, Andrea Surrage Calheiros et autres

are purinergic receptors physiologically activated by uridine nucleotides. These metabotropic Gq-coupled receptors induce intracellular calcium mobilization and are expressed in various cell types, particularly leukocytes. Their activation triggers proinflammatory responses, playing a critical role in the progression of inflammatory diseases, nociception, and …

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Chemical study of apolar extracts of leaves and branches of staminate individuals of Clusia lanceolata (Clusiaceae)

Nayara de Almeida Rodrigues Venancio, Camilly Panizzi Muniz, Adriana Quintella Lobão, Maria Raquel Figueiredo et autres

Abstract Clusia lanceolata is a dioecious species native and endemic to Brazil. The genus Clusia is characterised by the presence of flavonoids, benzophenones and terpenoids, the latter being considered as chemical markers. Despite its ecological importance, C. lanceolata has been poorly investigated …

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Isolation of phenolic compounds from Rheedia longifolia by high-speed countercurrent chromatography

Ana Luíza Rangel Bérenger, Flávia da Cunha Camillo, Lavínia de Carvalho Brito, Maria Auxiliadora Coelho Kaplan et autres

Abstract Rheedia longifolia is a species of the Clusiaceae family, popularly known as bacupari. Pharmacological studies conducted by our group revealed that the raw methanolic extract of its leaves, along with its fractions, induces both inflammatory and neurogenic antinociceptive effects, with low …

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Joannesia princeps Vell. inhibits purinergic P2Y receptors and presents antinociceptive and antiinflammatory effects

Natiele Carla da Silva Ferreira, Monique de Castro Pontes, Ana Luíza Rangel Bérenger, Maria Raquel Figueiredo et autres

HSCCC Straightforward Fast Preparative Method for Isolation of Two Major Cytotoxic Withanolides from Athenaea fasciculata (Vell.) I.M.C. Rodrigues & Stehmann

André Mesquita Marques, Lavínia de Carvalho Brito, Maria Raquel Figueiredo

Athenaea fasciculata belongs to the Solanaceae family and is a promising source of cytotoxic withanolides known as aurelianolides A and B. In the last years, the pharmacological studies of these aurelianolides on different leukemia cell lines have stimulated new studies on their …

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An Integrated Strategy of UHPLC-ESI-MS/MS Combined with Bioactivity-Based Molecular Networking for Identification of Antitumoral Withanolides from Athenaea fasciculata (Vell.) I.M.C. Rodrigues & Stehmann

André Mesquita Marques, Lavínia de Carvalho Brito, Simony Carvalho Mendonça, Brendo Araújo Gomes et autres

Background: Athenaea fasciculata, a Brazilian native species from the Solanaceae family, is recognized as a promising source of bioactive withanolides, particularly Aurelianolide A and B, which exhibit significant antitumoral activities. Despite its potential, research on the chemical constituents of this species remains …

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TANINOS CONDENSADOS DE ESPÉCIES DE PLUMBAGINACEAE

Selma Ribeiro de Paiva, Alan Patrick Heringer, Maria Raquel Figueiredo

RESUMO A família Plumbaginaceae é constituída por ervas ou subarbustos perenes de distribuição cosmopolita. O presente estudo visou avaliar o teor de taninos condensados em folhas de duas espécies de Plumbaginaceae: Plumbago auriculata Lam. e Plumbago scandens L. A extração dos taninos …

Larvicidal activity, enzyme inhibitory effect, and molecular docking by essential oil, hydrolate, aqueous extract, and major compounds from the leaves of Eugenia uniflora against Aedes aegypti

Ana Carla da Silva, André Mesquita Marques, Maria Raquel Figueiredo, Júlio César Ribeiro de Oliveira Farias de Aguiar et autres

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Antiparasitic Activity of Plumbago auriculata Extracts and Its Naphthoquinone Plumbagin against Trypanosoma cruzi

Raiza Brandão Peres, Marcos Meuser Batista, Ana Luíza Rangel Bérenger, Flávia da Cunha Camillo et autres

Chagas disease (CD) caused by the protozoan Trypanosoma cruzi affects more than six million people worldwide. Treatment is restricted to benznidazole (Bz) and nifurtimox (Nf) that display low activity in the later chronic stage besides triggering toxic events that result in treatment …

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