Naoaki Ito

Depressive symptoms attenuate the association between FGF21 response and sucrose intake in older adults

Shota Sakamoto, Saori Kakehi, Hideyoshi Kaga, Hiroki Tabata et autres

BACKGROUND: Depressive symptoms in late life are often accompanied by altered appetite and dietary behavior, yet the biological mechanisms linking metabolic signals to eating behavior remain poorly understood. Fibroblast growth factor 21 (FGF21) is a carbohydrate responsive hepatokine that suppresses sweet preference …

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Inside Front Cover

Tsubasa Tajima, HIDEYOSHI KAGA, Naoaki Ito, Toshiki Kogai et autres

The cover image is based on the article Dual action of imeglimin on insulin secretion and sensitivity in type 2 diabetes by Tsubasa Tajima MD et al., https://doi.org/10.1111/dom.70449 . image

Revisiting the TSH range in older adults: associations between subclinical hypothyroidism and geriatric conditions

Toshiki Kogai, HIDEYOSHI KAGA, Toyoyoshi Uchida, Hitoshi Naito et autres

Context: Thyroid-stimulating hormone (TSH) levels physiologically increase with age. Applying a fixed adult reference range to older adults may cause overdiagnosis of subclinical hypothyroidism (SCH). This study examined whether adjusting the upper limit of the TSH reference range is appropriate by evaluating …

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Dual action of imeglimin on insulin secretion and sensitivity in type 2 diabetes

Tsubasa Tajima, HIDEYOSHI KAGA, Naoaki Ito, Toshiki Kogai et autres

Abstract Aims Imeglimin is a novel oral hypoglycemic agent approved for the treatment of type 2 diabetes in Japan, with dual actions to enhance insulin secretion and improve insulin sensitivity, suggested by preclinical evidence. However, the effect of imeglimin on tissue‐specific insulin …

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Author response for "Dual Action of Imeglimin on Insulin Secretion and Sensitivity in Type 2 Diabetes Short running title: Imeglimin Improves Secretion and Sensitivity"

Tsubasa Tajima, HIDEYOSHI KAGA, Naoaki Ito, Toshiki Kogai et autres

Oral Semaglutide in an East Asian Population With Overweight or Obesity, With or Without Type 2 Diabetes

Takashi Kadowaki, Line Dam Heftdal, Hae‐Jin Ko, Maria Overvad et autres

Importance: The efficacy and safety of oral semaglutide, 50 mg, in an East Asian population that also includes individuals with type 2 diabetes (T2D), who are prone to weight-related complications at lower body mass index (BMI; calculated as weight in kilograms divided …

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Age-related differences in bone structural parameters using 3D-DXA and TBS in men and women: The Bunkyo Health Study

Hikaru Otsuka, Hiroki Tabata, Naoaki Ito, Huicong Shi et autres

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Factors Associated With Type 2 Diabetes in Older Japanese With Similar Genetic Risk Scores: The Bunkyo Health Study

Thu Hien Bui, Hideyoshi Kaga, Saori Kakehi, Yuki Someya et autres

Context: Genome-wide association studies have identified numerous single-nucleotide variations (SNVs, formerly single-nucleotide polymorphisms) linked to type 2 diabetes (T2D), thus improving the accuracy of genetic risk scores (GRS) in predicting T2D. Objective: This study aimed to investigate the association between the novel …

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Exercise habits in adolescence and old age are positively associated with geriatric depressive symptoms: the Bunkyo Health Study

Huicong Shi, Hiroki Tabata, Hikaru Otsuka, Hideyoshi Kaga et autres

Introduction: Exercise is a crucial method for preventing geriatric depression. In this cross-sectional study, we investigated the associations between exercise habits in adolescence and old age and geriatric depressive symptoms. Methods: This study used baseline data from the Bunkyo Health Study, a …

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Masseter Muscle Volume, Sarcopenia, and Muscle Determinants: Insights from ACTN3 Polymorphism in Elderly Japanese in the Bunkyo Health Study

Abulaiti Abudurezake, Saori Kakehi, Futaba Umemura, Hideyoshi Kaga et autres

AIM: Sarcopenia has been with a decrease in masseter muscle (MM) thickness in high-risk older populations. However, the relationship between sarcopenia and determinants of MM volume (MMV) in the general elderly population remains unclear. METHOD: In a cross-sectional study of 1,484 older …

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Rationale and Design of the Study to Investigate the Metabolic Action of Imeglimin on Patients with Type 2 Diabetes Mellitus (SISIMAI)

Tsubasa Tajima, Hideyoshi Kaga, Naoaki Ito, Toshiki Kogai et autres

INTRODUCTION: Imeglimin is a first-in-class, novel, oral glucose-lowering agent for the treatment of type 2 diabetes mellitus. The efficacy and safety of imeglimin as an antidiabetic agent have been investigated in clinical trials. However, its metabolic effects in humans have not yet …

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Obesity with low bone mineral density is a risk for cerebral small-vessel disease in older adults: The Bunkyo Health Study

Naoaki Ito, Hideyoshi Kaga, Yuki Someya, Hitoshi Naito et autres

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