Julián Maggio

Improving therapeutic strategies for triple-negative breast cancer: synergistic effects of DKC1 inhibition and paclitaxel

Román Vilarullo, María Del Pilar Casco, Vanesa Gottifredi, Lara Balcone et autres

BACKGROUND: Paclitaxel (PTX) is a standard treatment for triple-negative breast cancer (TNBC), but its effectiveness is often compromised by toxicity at therapeutic doses. Dyskerin pseudouridine synthase 1 (DKC1), a telomerase subunit, is overexpressed in TNBC and associated with poor prognosis. This study …

ar (code pays fourni par la source)

Role of PIN1 in human pathology: Cellular regulation, pathogenesis and therapeutic implications (Review)

Julián Maggio, Romina Armando, Lara Balcone, Román Vilarullo et autres

Peptidyl‑prolyl isomerase NIMA‑interacting 1 (PIN1) plays a crucial regulatory role in cells, and it is the only enzyme capable of selectively binding to phosphorylated proline‑directed serine/threonine (pSer/Thr‑Pro) residues in target proteins and catalyzing their isomerization. The change in the conformational status of …

ar (code pays fourni par la source)

Key role of PIN1 in telomere maintenance and oncogenic behavior in a human glioblastoma model

Julián Maggio, Georgina A. Cardama, Romina Armando, Lara Balcone et autres

PIN1 is the only known enzyme capable of recognizing and isomerizing the phosphorylated Serine/Threonine‑Proline motif. Through this mechanism, PIN1 controls diverse cellular functions, including telomere maintenance. Both PIN1 overexpression and its involvement in oncogenic pathways are involved in several cancer types, including …

ar (code pays fourni par la source)

Preclinical Efficacy and Toxicology Evaluation of RAC1 Inhibitor 1A-116 in Human Glioblastoma Models

Georgina A. Cardama, Julián Maggio, Lucas Valdez Capuccino, Nazareno González et autres

Malignant gliomas are the most common primary central nervous system tumor in adults. Despite current therapeutics, these tumors are associated with poor prognosis and a median survival of 16 to 19 months. This highlights the need for innovative treatments for this incurable …

ar (code pays fourni par la source)

In vitro characterization and rational analog design of a novel inhibitor of telomerase assembly in MDA MB 231 breast cancer cell line

Romina Armando, Maia Cabrera, Román Vilarullo, Patricio Chinestrad et autres

Tumor cells have unlimited replicative potential, principally due to telomerase activity, which requires assembly of components such as dyskerin (hDKC1), human telomerase reverse transcriptase and human telomerase RNA (hTR). The present study aimed to develop novel inhibitors of telomerase to target the …

ar (code pays fourni par la source)

Rational design of PIN1 inhibitors for cancer treatment based on conformational diversity analysis and docking based virtual screening

Julián Maggio, Maia Cabrera, Romina Armando, Patricio Chinestrad et autres

The parvulin PIN1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1), is the only enzyme capable of isomerizing prolines of phospho-Serine/Threonine-Proline motifs. PIN1 binds to a subset of proteins and plays an essential role in regulating protein function post-phosphorylation control. Furthermore, the activity of PIN1 …

ar (code pays fourni par la source)

Rational design of PIN1 inhibitors for cancer treatment based on conformational diversity analysis and docking based virtual screening

Julián Maggio, Maia Cabrera, Romina Armando, Patricio Chinestrad et autres

The parvulin PIN1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1), is the only enzyme capable of isomerizing prolines of phospho-Serine/Threonine-Proline motifs. PIN1 binds to a subset of proteins and plays an essential role in regulating protein function post-phosphorylation control. Furthermore, the activity of PIN1 …

Telomeropathies: Etiology, diagnosis, treatment and follow‐up. Ethical and legal considerations

Romina Armando, Diego Luis Mengual Gómez, Julián Maggio, María C. Sanmartin et autres

Telomeropathies involve a wide variety of infrequent genetic diseases caused by mutations in the telomerase maintenance mechanism or the DNA damage response (DDR) system. They are considered a family of rare diseases that often share causes, molecular mechanisms and symptoms. Generally, these …

ar (code pays fourni par la source)

[Rho GTPases as molecular targets in cancer. Strategies and therapeutic opportunities].

Julián Maggio, Nazareno González, Georgina Alexandra Cardama, Daniel E. Gómez

Rho GTPases are molecular switches that control the different cellular processes. Deregulation of these proteins is associated to transformation and malignant progression in several cancer types. Given the evidence available of the role of Rho GTPases in cancer it is suggested that …

ar (code pays fourni par la source)

Author response for "Telomeropathies: Aetiology, diagnosis, treatment and follow-up. Ethical and legal considerations"

Romina Armando, Diego Luis Mengual Gómez, Julián Maggio, María Cecilia Sanmartin

El impacto de la exigencia de encajes en los spreads y las tasas activas y pasivas de las entidades financieras

Julián Maggio

El objetivo de este trabajo es calcular el efecto de la exigencia de encajes en los spreads y las tasas pasivas y activas en Argentina, con especial foco en el régimen de metas de inflación iniciado en noviembre de 2015. La muestra …

ar (code pays fourni par la source)

Relevance of small GTPase Rac1 pathway in drug and radio-resistance mechanisms: Opportunities in cancer therapeutics

Georgina A. Cardama, Daniel F. Alonso, Nazareno González, Julián Maggio et autres

ar, be (code pays fourni par la source)