Tarun W. Dasari

Cardioprotection Is a Delivery Problem: A First-Medical-Contact Framework for Acute Myocardial Infarction

Vibhudutta Awasthi, Tarun W. Dasari, Kenichi A. Tanaka

Abstract Dozens of agents that limit reperfusion injury preclinically have failed clinically. These failures are architectural, not biological: the right biology reaches the wrong place, as the wrong molecule, at the wrong time, judged by the wrong end point. We recast each …

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Transcutaneous vagus nerve stimulation in postural orthostatic tachycardia syndrome: A systematic search and narrative synthesis of three clinical studies

Kshitiz Pandey, Pratik Pandey, Ashish Panday, Sushmita Khanal et autres

EDA-fibronectin defines an early molecular target for imaging cardiac remodeling

Andrea S. Ramirez-Sagredo, Hung Anh Nguyen, Venkateswararao Eeda, Maitreyee Das et autres

Fibrotic remodeling is a primary driver of heart failure, yet early molecular events remain difficult to detect non-invasively. Cellular fibronectin (cFN), an alternatively spliced fibronectin isoform containing the extra domain A (EDA), is rapidly induced during early tissue repair and precedes collagen …

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β2 adrenergic receptors orchestrate neutrophil demargination and recruitment to the ischemic heart following myocardial infarction

Albert Dahdah, Krishna P. Maremanda, MathanKumar Marimuthu, Ki Ho Park et autres

Neutrophils play a crucial role in instigating inflammation as well as its resolution post-myocardial infarction (MI). Although granulopoiesis in the bone marrow (BM) is the major source of cardiac neutrophils post-MI, infiltration of neutrophils to the heart occurs much quicker than peak …

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Utilization and Prognosis of Cardiac Device Implantation in AL Versus ATTR Amyloidosis

Bilal Hussain, Sanchit Duhan, Khawaja Hassan Akhtar, Amith Reddy Seri et autres

INTRODUCTION: Cardiac amyloidosis can cause congestive heart failure, arrhythmias, and heart blocks, which frequently require cardiac device implantation (CDI). However, the differences between light chain (AL) amyloidosis and transthyretin (ATTR) amyloidosis CDI requirements are unknown. METHODS: A retrospective analysis was conducted using …

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Increased blood pressure variability - A risk of Alzheimer’s disease?

Michiaki Nagai, Keigo Dote, Tarun W. Dasari

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Sympathetic Hyperactivity In Patients With Durable Left Ventricular Assist Device

Pratik Pandey, Sushmita Khanal, Zahra Mehdipournamdar, Michiaki Nagai et autres

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Heart Rate Variability Metrics In Heart Transplant Recipients-A Narrative Review

Zahra Mehdipournamdar, Sushmita Khanal, Pratik Pandey, Michiaki Nagai et autres

Heart Rate Variability Metrics In Patients With Durable Ventricular Assist Device-A Narrative Review

Pratik Pandey, Sushmita Khanal, Zahra Mehdipournamdar, Michiaki Nagai et autres

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Central Pressure Variability After Low-Level Tragus Stimulation in Acute Decompensated Heart Failure

Michiaki Nagai, Keigo Dote, Masaya Kato, Shota Sasaki et autres

BACKGROUND: Increased variability in central aortic systolic pressure (CASP) and pulse pressure (PP) are predictors of poor cardiovascular disease outcomes. Low-level tragus stimulation (LLTS) is a noninvasive method to reduce sympathetic tone via vagal afferent fibers. It is unknown if LLTS has …

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Association between non-invasive auricular stimulation and blood pressure lowering: a systematic review and meta-analysis

Michiaki Nagai, Karl‐Philipp Rommel, Yukiko Nakano, Phillip J. Tully et autres

Abstract Earlier clinical trials have investigated the efficacy of auricular stimulation for hypertension, but the overall evidence regarding the effect of non-invasive auricular stimulation on blood pressure (BP) reduction remains unclear. This systematic review summarizes the effects of non-invasive auricular stimulation on …

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Utility of short-term heart rate variability metrics in heart failure with reduced ejection fraction

Michiaki Nagai, Sunny S. Po, Benjamin J. Scherlag, Tarun W. Dasari

Background Recently, reduced sympathetic nervous system (SNS) activity measured by 10-minute electrocardiogram (EKG)-based heart rate (HR) variability (HRV) was associated with heart failure (HF) with recovered ejection fraction (EF) (HFrecEF). However, there are no studies on the optimal EKG recording time to …

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