Golbarg Rahimi

Circulating Tumor DNA (ctDNA) Clearance After Immune Checkpoint Inhibition (ICI) with Radiotherapy (RT) as a Prognostic Biomarker for Advanced Melanoma

Alyssa K. Steimle, Amir Masoud Forati, Alice Yao Zhou, Trevor McCracken et autres

Background/Objectives: ctDNA is evolving as an important biomarker for prognostic assessment in advanced melanoma. However, the utility of ctDNA monitoring during concurrent ICI with RT remains incompletely explored. Methods: In this multicenter retrospective study, patients with unresectable stage III/IV melanoma treated with …

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Circulating Tumor DNA (ctDNA) Clearance After Immune Checkpoint Inhibition (ICI) with Radiotherapy (RT) as a Prognostic Biomarker for Advanced Melanoma

Alyssa K. Steimle, Amir Forati, Alice Yao Zhou, Trevor McCracken et autres

ctDNA is evolving as an important biomarker for ICI treatment response assessment in advanced melanoma. However, the utility of ctDNA monitoring during concurrent ICI with RT remains incompletely explored. In this multicenter, retrospective study, patients with unresectable stage III/IV melanoma treated with …

POSTER: CT-385: Higher Early-Posttransplant Tacrolimus Levels Are Associated With Inferior Survival Outcomes After Matched Unrelated Donor Allogeneic Hematopoietic Stem Cell Transplantation

Hien Lau, Golbarg Rahimi, Brandon Tang, Ellie Gibbs et autres

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CT-385: Higher Early-Posttransplant Tacrolimus Levels Are Associated With Inferior Survival Outcomes After Matched Unrelated Donor Allogeneic Hematopoietic Stem Cell Transplantation

Hien Lau, Golbarg Rahimi, Brandon Tang, Ellie Gibbs et autres

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Circulating tumor DNA (ctDNA) clearance after immune checkpoint inhibition (ICI) with radiotherapy (RT) as a prognostic indicator for patients with advanced melanoma.

Alyssa K. Steimle, Amir Forati, Alice Yao Zhou, Trevor McCracken et autres

9533 Background: ctDNA is becoming a useful biomarker for ICI treatment response assessment in advanced melanoma. RT is capable of producing an abscopal effect, potentially enhancing ICI efficacy. The utility of ctDNA monitoring with concurrent ICI and RT remains incompletely explored. Here, …

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Optimal timing of circulating tumor DNA (ctDNA) dynamics to prognosticate immune checkpoint inhibitors (ICI) efficacy in patients with advanced stage melanoma.

Vincent The-Luc Ma, Amir Forati, Alice Yao Zhou, Trevor McCracken et autres

9534 Background: ctDNA predicts relapse in resected tumors, but its role in advanced disease is less defined. We previously reported that early ctDNA changes at 3-4 weeks after ICI initiation can inform treatment response and survival. In this study, we attempt to …

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Impact of early tacrolimus levels on survival outcomes following allogeneic hematopoietic stem cell transplantation.

Golbarg Rahimi, Hien Lau, Brandon Tang, Ellie Gibbs et autres

e18563 Background: Tacrolimus is routinely used for graft-versus-host disease (GVHD) prophylaxis after allogeneic hematopoietic stem cell transplantation (HSCT); however, the prognostic impact of early post-transplant tacrolimus exposure remains unclear. We evaluated the association between tacrolimus levels within 30 days after allogeneic HSCT …

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Prognostic significance of ctDNA detection at the time of relapse during melanoma surveillance.

Soham Ali, Amir Forati, Alyssa K. Steimle, Trevor McCracken et autres

e21543 Background: Circulating tumor DNA (ctDNA) is an emerging biomarker of progression and relapse in multiple cancers. Our earlier single-center data demonstrated that site of melanoma relapse impacted the sensitivity of ctDNA detection. In this multi-institutional study, we further examined the prognostic …

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Incidence and outcomes of diabetic ketoacidosis in hospitalized adults with COVID-19: A retrospective cohort study

Nikitha Reddy, Stefano A. Iantorno, Golbarg Rahimi, Andy Liu et autres

Rationale COVID-19 has varied clinical manifestations. Limited data suggests that diabetic ketoacidosis (DKA) in COVID-19 patients is associated with greater mortality than in non-COVID-19 patients. We hypothesized that COVID-19 patients with DKA would have increased mortality than those without DKA.Objectives To evaluate …

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Leber’s hereditary optic neuropathy and multiple sclerosis: overlap between mitochondrial disease and neuroinflammation

Golbarg Rahimi, Mackenzie Silverman, Lilia Kazerooni, Mariam M Yousuf et autres

Although Multiple sclerosis (MS) and Leber hereditary optic neuropathy (LHON) have distinct pathophysiological mechanisms, they are both neurodegenerative conditions that involve mitochondrial dysfunction. MS is an autoimmune disease that is characterized by demyelination and neuroinflammation; and LHON is a mitochondrial disorder predominantly …

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Chemoimmunotherapy in Advanced, PD‐1 Refractory Cutaneous Squamous Cell Carcinoma: Insights From Two Immunocompromised Patient Cases

Golbarg Rahimi, Gino Kim In

Cutaneous squamous cell carcinoma (cSCC) is one of the most prevalent malignancies worldwide, and a subset of patients, particularly immunocompromised individuals, will face heightened risks of metastasis and mortality. This report examines two cases of immunocompromised patients treated with a combination of …

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Incretin-responsive human pancreatic adipose tissue organoids: A functional model for fatty pancreas research

Estela Lorza‐Gil, Olaf Strauß, Eckart Ziegler, Katinka Kansy et autres

OBJECTIVE: Infiltration of adipocytes into the pancreatic parenchyma has been linked to impaired insulin secretion in individuals with increased genetic risk of T2D and prediabetic conditions. However, the study of this ectopic fat depot has been limited by the lack of suitable …

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