Accès ouvert
2026
article
OpenAlex
Maria Teresa Venuti, Federico Brandalise, Mattia Cappelletti, Attilio Francesco Speciani et autres
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder increasingly associated with cognitive impairment and neurodegeneration. Peripheral metabolic dysfunction, particularly insulin resistance and glycation stress, represents a critical link between diabetes and brain pathology. This study investigated the relationship between metabolic …
it
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Accès ouvert
2025
article
OpenAlex
Ramona Stringhi, Silvia Pelucchi, Laura D’Andrea, Filippo La Greca et autres
Alzheimer's disease (AD) is marked by synaptic failure, with actin cytoskeleton alterations playing a key role in its pathogenesis. Cofilin, a regulator of actin dynamics in dendritic spines, forms cofilin-actin rods upon exposure to amyloid-β (Aβ) oligomers, contributing to synaptic loss. Cyclase-associated …
it
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Accès ouvert
2025
review
OpenAlex
Rachele Bianco, Monica Ferraroni, Michela Carola Speciani, Maria Teresa Parpinel et autres
The strength, direction, and trend of associations between specific diseases and reproducible a posteriori dietary patterns (DPs) based on principal component analysis (PCA) or exploratory factor analysis (EFA) have rarely been investigated across populations. We conducted a systematic review of PCA/EFA-based DPs …
it
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Accès ouvert
2023
review
OpenAlex
Rachele Bianco, Michela Carola Speciani, Maria Teresa Parpinel, M Tesi et autres
Although a posteriori dietary patterns (DPs) naturally reflect actual dietary behavior in a population, their specificity limits generalizability. Among other issues, the absence of a standardized approach to analysis have further hindered discovery of genuinely reproducible DPs across studies from the same/similar …
it
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Accès ouvert
2023
article
OpenAlex
Luisella Vigna, Michela Carola Speciani, Amedea Silvia Tirelli, Francesca Bravi et autres
Serum vitamin D (VitD) levels have been inversely related with metabolic syndrome (MetS), although the direct impact of VitD is still debated. This study examined 879 subjects of working age from an obesity and occupational clinic in Milan, Italy. Among these participants, …
it
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Accès ouvert
2023
article
OpenAlex
Roberta De Vito, Maria Teresa Parpinel, Michela Carola Speciani, Federica Fiori et autres
To our knowledge, no studies so far have investigated the role of pizza and its ingredients in modulating disease activity in rheumatoid arthritis (RA). We assessed this question via a recent cross-sectional study including 365 participants from Italy, the birthplace of pizza. …
us, it
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Accès ouvert
2023
article
OpenAlex
Silvia Pelucchi, Chiara Macchi, Laura D’Andrea, Paolo Dionigi Rossi et autres
Frailty is a geriatric syndrome that results from multisystem impairment caused by age-associated accumulation of deficits. The frailty index is used to define the level of frailty. Several studies have searched for molecular biomarkers associated with frailty, to meet the needs for …
it, br
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Accès ouvert
2023
article
OpenAlex
Michela Carola Speciani, Giorgio Gargari, Roberto Penagini, Massimiliano Mutignani et autres
PURPOSE: Garlic consumption has been inversely associated to intestinal adenoma (IA) and colorectal cancer (CRC) risk, although evidence is not consistent. Gut microbiota has been implied in CRC pathogenesis and is also influenced by garlic consumption. We analyzed whether dietary garlic influence …
it, gb
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Accès ouvert
2022
article
OpenAlex
Michela Carola Speciani, Marcello Cintolo, Mirko Marino, M. Necat Ören et autres
Flavonoids have been inversely associated to colorectal cancer (CRC) and are plausible intermediaries for the relation among gut microbiome, intestinal permeability and CRC. We analyzed the relation of flavonoid intake with CRC and blood bacterial DNA. We conducted a case–control study in …
it, us, gr
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Accès ouvert
2021
article
OpenAlex
Massimiliano Mutignani, Roberto Penagini, Giorgio Gargari, Simone Guglielmetti et autres
Inflammation and immunity are linked to intestinal adenoma (IA) and colorectal cancer (CRC) development. The gut microbiota is associated with CRC risk. Epithelial barrier dysfunction can occur, possibly leading to increased intestinal permeability in CRC patients. We conducted a case-control study including …
it
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Accès ouvert
2021
preprint
OpenAlex
Massimiliano Mutignani, Roberto Penagini, Giorgio Gargari, Simone Guglielmetti et autres
ABSTRACT Objective We aimed to investigate the relation of blood bacterial DNA load and profiling with intestinal adenoma (IA) and colorectal cancer (CRC) patients. Design We performed 16S rRNA gene analysis of blood from 100 incident histologically confirmed CRC cases, 100 IA …
it
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Accès ouvert
2020
article
OpenAlex
Mattia Cappelletti, Emiliana Tognon, Linda Vona, Katia Basello et autres
BACKGROUND: Irritable Bowel Syndrome (IBS) is a widespread disease with variable symptoms that have an important impact on the quality of life. Despite the prevalence of IBS, its etiology and pathophysiology are still to be fully understood, but immune response is known …
it
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