Lucas Turner

Prenatally Educated Friendly NK Cells Expand FOXP3+Tregs and Reduce Tc17 Cells Via Increased TGF-B1 and Decreased GM-CSF Production 4833

Hee Kap Kang, Daniel Liesman, Catherine Redden, Lucas Turner et autres

Abstract Description Prenatal foreign antigen exposure before immune competence results in lifelong antigen-specific tolerance. In our prenatal allotransplantation model, tolerant NK cells (engrafter friendly NK, fNK) suppressed type 1 and 17 allo-specific T cell responses via increased TGF-b1 production and Foxp3+CD4+Treg expansion. …

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Co-stimulation of allo responsive NK cells with an NK cell-specific ligand enhances allo-specific rejection and memory in prenatal chimeras 4828

Hee Kap Kang, Daniel Liesman, Catherine Redden, Lucas Turner et autres

Abstract Description Prenatal foreign antigen exposure leads to lifelong stable tolerance, but also can result in non-tolerance to the donor antigen and cause graft rejection. In prenatal allotransplantation model (Balb/c to C57BL/6), allo-specific (Ly49D) NK cells play a key role in engraftment …

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Maternal Plasma Micro-RNAs in Fetal Congenital Diaphragmatic Hernia: A Potential Non-invasive Tool for Prenatal Diagnosis and Risk Stratification

Daniel Liesman, Cassandra Huerta, Steven T. Papastefan, Morgan Langereis et autres

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Maternal plasma microRNA profiles in twin-twin transfusion syndrome and normal monochorionic twin pregnancies

Steven T. Papastefan, Morgan Langereis, Catherine Redden, Daniel Liesman et autres

Introduction: Ultrasound-based staging systems for twin-twin transfusion syndrome (TTTS) are limited by radiologic expertise, fetal positioning, and timing of the exam, and may benefit from incorporation of objective biochemical measures for diagnosis and prognostication. microRNA expression is altered in amniotic fluid of …

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Severe gut mucosal injury induces profound systemic inflammation and spleen-associated lymphoid organ response

Xiao Wang, Chao Du, Saravanan Subramanian, Lucas Turner et autres

Clinical evidence indicates a connection between gut injuries, infections, inflammation, and an increased susceptibility to systemic inflammation. Nevertheless, the animal models designed to replicate this progression are inadequate, and the fundamental mechanisms are still largely unknown. This research explores the relationship between …

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Prenatally Educated Friendly NK Cells regulate Allo-specific T cell Responses through expansion of Foxp3+CD4+Treg Cells and suppression of Type 1 and 17 CD8+T cell responses

Hee Kap Kang, Steven T. Papastefan, Lucas Turner, Catherine Redden et autres

Abstract Prenatal alloantigen exposure during embryonic development permanently tolerizes the early gestational fetus and provides a tremendous advantage over transplantation after birth. However, the influence of prenatally educated NK cells on alloantigen-specific T cell immune responses is not well elucidated. In previous …

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CD4 and IL-2 mediated NK cell responses after COVID-19 infection and mRNA vaccination in adults

Amir M. Alhajjat, Catherine Redden, Morgan Langereis, Steven T. Papastefan et autres

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Concurrent 19. Presentation for: Developing an in-depth understanding of PFAS to deliver an effective remediation strategy

Lucas Turner

Presented on Wednesday 18 May: Session 19 Esso Australia Resources Pty Ltd and BHP Petroleum (Bass Strait) Pty Ltd own a range of offshore and onshore hydrocarbon production facilities, which have been operated by Esso Australia Pty Ltd (Esso) for over 50 …

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Developing an in-depth understanding of PFAS to deliver an effective remediation strategy

Lucas Turner, David Prismall

Esso Australia Resources Pty Ltd and BHP Petroleum (Bass Strait) Pty Ltd own a range of offshore and onshore hydrocarbon production facilities, which have been operated by Esso Australia Pty Ltd (Esso) for over 50 years. The Longford Fire Training Ground (FTG) …

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Prenatal Rejecter NK Cells Enhance Allo-specific Th17/Tc17 Cell Responses via TGF-beta1, IL-6 and GM-CSF.

Hee Kap Kang, Katherine C. Ott, Lucas Turner, Catherine Redden et autres

Abstract In utero hematopoietic cellular transplantation (IUHCT) has the potential to treat congenital benign cellular disease without chemotherapy or radiation. Prenatal tolerance is essential in this regard. Previous studies involving prenatally created chimeras have shown that immunologically tolerant NK cells (friendly, fNK) …

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Loss of Allospecific Activating Receptor Expressing NK Cells Results in Maternal Tolerance of the Aberrant Fetus

Katherine C. Ott, Marc Oria, Catherine C. Redden, Hee Kap Kang et autres

Ott, Katherine C. MD; Oria, Marc PhD; Redden, Catherine C. MS; Kang, Hee K. PhD; Skital, Veronica M. MD; Turner, Lucas E. BS; Alhajjat, Amir M. MD; Duru, Soner MD; Peiro, Jose L. MD; Shaaban, Aimen F. MD, FACS Author Information

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Absorption After Neural Tube Teratogenesis is Dependent on Maternal Immune Cell Function

Katherine C. Ott, Marc Oria, Catherine Redden, Hee Kap Kang et autres

Abstract Introduction Neural tube defects (NTDs), are severe malformations of the developing central nervous system. After having a pregnancy affected by NTD, the recurrence risk increases 20x. The predisposition to having children affected by NTDs has not been explained and may relate …

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