Sofia Ferreira

Data from Inactivation of CDKN2AARF Promotes p53-Independent Remodeling of the PDAC Tumor Microenvironment

Sofia Ferreira, Brittany M. Flowers, Won-Young Choi, Maria Farina-Morillas et autres

Abstract The CDKN2A locus, which is frequently deleted in pancreatic ductal adenocarcinoma (PDAC), encodes two tumor suppressors, ARF and INK4A, that may influence tumorigenesis through distinct mechanisms. Distinguishing their individual contributions to cancer could help improve the understanding of PDAC pathogenesis and …

Supplementary Figure S2 from Inactivation of CDKN2AARF Promotes p53-Independent Remodeling of the PDAC Tumor Microenvironment

Sofia Ferreira, Brittany M. Flowers, Wonyoung Choi, Maria Farina-Morillas et autres

Summary of types of mutations found in CDKN2AARF and CDKN2AINK4A in Group 1 to 4 PDACs.

Supplementary Figure S1 from Inactivation of CDKN2AARF Promotes p53-Independent Remodeling of the PDAC Tumor Microenvironment

Sofia Ferreira, Brittany M. Flowers, Wonyoung Choi, Maria Farina-Morillas et autres

Identification of 4 groups within TCGA PAAD data.

Supplementary Table S3 from Inactivation of CDKN2AARF Promotes p53-Independent Remodeling of the PDAC Tumor Microenvironment

Sofia Ferreira, Brittany M. Flowers, Wonyoung Choi, Maria Farina-Morillas et autres

RNA-sequencing data

Supplementary Figure S3 from Inactivation of CDKN2AARF Promotes p53-Independent Remodeling of the PDAC Tumor Microenvironment

Sofia Ferreira, Brittany M. Flowers, Wonyoung Choi, Maria Farina-Morillas et autres

Analysis of PDAC development from adult mouse acinar cells across different Arf and Trp53 genotypes

Supplementary Figure S4 from Inactivation of CDKN2AARF Promotes p53-Independent Remodeling of the PDAC Tumor Microenvironment

Sofia Ferreira, Brittany M. Flowers, Wonyoung Choi, Maria Farina-Morillas et autres

CDKN2A alterations are common in mouse KTC PDACs.

Supplementary Table S2 from Inactivation of CDKN2AARF Promotes p53-Independent Remodeling of the PDAC Tumor Microenvironment

Sofia Ferreira, Brittany M. Flowers, Wonyoung Choi, Maria Farina-Morillas et autres

Details of mouse acinar cell-derived tumors used for RNA-sequencing analysis

Supplementary Table S1 from Inactivation of CDKN2AARF Promotes p53-Independent Remodeling of the PDAC Tumor Microenvironment

Sofia Ferreira, Brittany M. Flowers, Wonyoung Choi, Maria Farina-Morillas et autres

Phenotypes in acinar cell of origin Arf knockout and double Arf and Trp53 knockout mouse cohorts

Supplementary Figure S6 from Inactivation of CDKN2AARF Promotes p53-Independent Remodeling of the PDAC Tumor Microenvironment

Sofia Ferreira, Brittany M. Flowers, Wonyoung Choi, Maria Farina-Morillas et autres

Expression of Ink4a and a p53 tumor suppression-associated gene (TSAG) signature

Supplementary Figure S5 from Inactivation of CDKN2AARF Promotes p53-Independent Remodeling of the PDAC Tumor Microenvironment

Sofia Ferreira, Brittany M. Flowers, Wonyoung Choi, Maria Farina-Morillas et autres

Transcriptome analysis of PDACs from KTC, KTC;Trp53fl/fl, KTC;Arffl/fl and KTC;Trp53fl/fl; Arffl/fl mice

DNA methylation-based classification uncovers acinar and ductal origins for KPC-derived PDAC cell lines

Ilianna Zoi, Memoona Rajput, Adrián Holguín-Horcajo, Malak Haidar et autres

be, es, ca, us, de, fr (code pays fourni par la source)

Inactivation of CDKN2A ARF Promotes p53-Independent Remodeling of the PDAC Tumor Microenvironment

Sofia Ferreira, Brittany M. Flowers, Won-Young Choi, Maria Farina-Morillas et autres

The CDKN2A locus, which is frequently deleted in pancreatic ductal adenocarcinoma (PDAC), encodes two tumor suppressors, ARF and INK4A, that may influence tumorigenesis through distinct mechanisms. Distinguishing their individual contributions to cancer could help improve the understanding of PDAC pathogenesis and potentially …

us, es, hu (code pays fourni par la source)