2026
preprint
OpenAlex
Nienke B. Goedhart, Elena Camerini, Gaspard Cretenet, Anita E. Grootemaat et autres
Summary T-cell metabolic dysfunction is increasingly recognized as a hallmark of poor antitumor responses. Still, how distinct metabolic states shape T-cell function and which signaling pathways sustain them remains unclear. Here, we show that T cells from patients with chronic lymphocytic leukemia …
nl, de, us, fr, es
(code pays fourni par la source)
2015
article
OpenAlex
Martijn H.A. van Attekum, Sanne Terpstra, Emilie Reinen, Marieke v. Lindern et autres
Abstract Survival of CLL cells critically depends on heterotypic communication with benign bystanders cells in micro-environmental niches such as lymph node (LN) tissue. Here, mesenchymal stromal cells and macrophages, in concert with CD40L expressing T cells, are thought to participate in the …
nl
(code pays fourni par la source)
2011
article
OpenAlex
María Fernanda Pascutti, Jacqueline Maria Tromp, Margot Jak, Ingrid A. M. Derks et autres
Abstract Abstract 3871 Introduction: Lymph nodes (LN) from chronic lymphocytic leukaemia (CLL) patients contain characteristic proliferation centres, which are interspersed with CD154+ CD4+ T cells. We have previously shown that in vitro stimulation of peripheral blood (PB) CLL cells with CD154-expressing fibroblasts …
nl
(code pays fourni par la source)