Michaela Fuchs

Hypoxia‐inducible factor‐2 stabilization is not sufficient to induce erythropoietin production in deeper medullary fibroblasts

Michaela Fuchs, Lena M. Süß, A. W. Forst, Armin Kurtz et autres

Abstract Under hypoxaemic conditions, cortical fibroblasts primarily produce erythropoietin (EPO). However, we have previously shown that most interstitial fibroblasts positive for platelet‐derived growth factor receptor β (PDGFR‐β) in all kidney zones are also able to produce EPO. Therefore, we wondered if either …

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Michaela Fuchs, Myles Wolf, Alexander Grabner

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Das hadrianische Bogentor und ›Neuathen‹

Michaela Fuchs

Die Inschriften des hadrianischen Bogentors in Athen haben schon in der Antike zu Schlussfolgerungen geführt, die bis heute die Forschung beschäftigen. Maßgeblich sind dabei die auf diese Inschriften rekurrierenden Schriftquellen, welche den Bogen als den Durchgang in einer uralten Stadtmauer und eine …

Clinical evidence for independent regulation of vitamin D by intestinal CYP24A1. Reply.

Michaela Fuchs, Myles Wolf

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Entwicklung und Struktur der Pendlerverflechtungen Sachsen-Anhalts

Michaela Fuchs, Birgit Fritzsche, Uwe Sujata

Pendeln erfüllt eine wichtige Funktion beim räumlichen Ausgleich von Arbeitsangebot und Arbeitsnachfrage. Aus Sachsen-Anhalt pendelten im Jahr 2024 über 148.000 sozialversicherungspflichtig Beschäftigte in andere Bundesländer, was 17 Prozent aller Beschäftigten mit Wohnort in Sachsen-Anhalt entspricht. Gleichzeitig hatten über 76.000 Beschäftigte aus anderen …

Fibroblast growth factor 23 and fibroblast growth factor receptor 4 promote cardiac metabolic remodeling in chronic kidney disease

Michaela Fuchs, Emily J. Burke, Nejla Latic, Susan Murray et autres

Chronic kidney disease (CKD) is a global health epidemic that greatly increases mortality due to cardiovascular disease. Left ventricular hypertrophy (LVH) is an important mechanism of cardiac injury in CKD. High serum levels of fibroblast growth factor (FGF) 23 in patients with …

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Intestinal Cyp24a1 regulates vitamin D locally independent of systemic regulation by renal Cyp24a1 in mice

Michaela Fuchs, Alexander Grabner, Melody Shi, Susan Murray et autres

Vitamin D regulates mineral homeostasis. The most biologically active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D), is synthesized by CYP27B1 from 25-dihydroxyvitamin D (25D) and is inactivated by CYP24A1. Human monogenic diseases and genome-wide association studies support a critical role for CYP24A1 …

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Tissue-Specific Deletion of Cyp24a1 Reveals Independent Systemic and Intestinal Vitamin D Regulation in Mice

Michaela Fuchs, Alexander Grabner, Melody Shi, Emily Burke et autres

Background: Dysregulation of vitamin D, a central regulator of mineral metabolism, is a severe complication of chronic kidney disease (CKD), leading to hypocalcemia, secondary hyperparathyroidism and increased risk of fractures. The most biologically active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D), is …

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Klotho and Clinical Outcomes in CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study

Daniel Edmonston, Michaela Fuchs, Emily J. Burke, Tamara Isakova et autres

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How many gaps are there? Investigating the regional dimension of the gender commuting gap

Michaela Fuchs, Ramona Jost, Antje Weyh

This paper investigates the gender gap in commuting by differentiating between the place of residence and work in urban and rural regions. Using administrative geo-referenced data for Germany and applying decomposition techniques, we provide evidence for a triple gap in commuting to …

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Fibroblast Growth Factor (FGF) 23 and FGF Receptor 4 promote cardiac metabolic remodeling in chronic kidney disease

Alexander Grabner, Michaela Fuchs, Emily Burke, Nejla Latic et autres

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CKD Causes Cardiac Metabolic Remodeling via FGF23 and FGFR4

Michaela Fuchs, Emily Burke, Myles Wolf, Alexander Grabner

Background: In chronic kidney disease (CKD), serum levels of fibroblast growth factor (FGF) 23 are associated with increased risks of left ventricular hypertrophy (LVH), heart failure and death. We reported that FGF23 directly induces hypertrophic growth of cultured cardiomyocytes and structural cardiac …

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