Benjamin Schiller

Predicting complications in paediatric ulcerative colitis: A longitudinal multicentre cohort study

Merle Claßen, Benjamin Schiller, Jan Däbritz

BACKGROUND: To prevent complications of paediatric ulcerative colitis (UC), it is critical to understand their predictors. The Paediatric Inflammatory Bowel Disease Ahead (PIBD Ahead) program identified the relevant outcomes and their potential predictors. However, external validation of these results in larger cohorts …

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BoFire: Bayesian Optimization Framework Intended for Real Experiments

Johannes P. Dürholt, Thomas S. Asche, Johanna Kleinekorte, Gabriel Mancino-Ball et autres

Our open-source Python package BoFire combines Bayesian Optimization (BO) with other design of experiments (DoE) strategies focusing on developing and optimizing new chemistry. Previous BO implementations, for example as they exist in the literature or software, require substantial adaptation for effective real-world …

Corrigendum: Identifying predictors of clinical outcomes using the projection-predictive feature selection—a proof of concept on the example of Crohn's disease

Elisa Wirthgen, Frank Weber, Laura Kubickova-Weber, Benjamin Schiller et autres

In the published article, there was an error in the Supplementary Material (Date Sheet 1). The source code mentioned in the “Data Availability Statement“ has been corrected in the Open Science Framework (OSF) at https://doi.org/10.17605/OSF.IO/EMWGP. This correction of the source code affects …

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Epidemiology of 7375 children and adolescents hospitalized with COVID-19 in Germany, reported via a prospective, nationwide surveillance study in 2020–2022

Maren Doenhardt, Markus Hufnagel, Natalie Diffloth, Johannes Hübner et autres

By means of a nationwide, prospective, multicenter, observational cohort registry collecting data on 7375 patients with laboratory-confirmed SARS-CoV-2 admitted to children's hospitals in Germany, March 2020-November 2022, our study assessed the clinical features of children and adolescents hospitalized due to SARS-CoV-2, evaluated …

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Identifying predictors of clinical outcomes using the projection-predictive feature selection—a proof of concept on the example of Crohn’s disease

Elisa Wirthgen, Frank Weber, Laura Kubickova-Weber, Benjamin Schiller et autres

Objectives: Several clinical disease activity indices (DAIs) have been developed to noninvasively assess mucosal healing in pediatric Crohn's disease (CD). However, their clinical application can be complex. Therefore, we present a new way to identify the most informative biomarkers for mucosal inflammation …

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Large Duodenal Hematoma Causing an Ileus after an Endoscopic Duodenal Biopsy in a 6-Year-Old Child: A Case Report

Benjamin Schiller, Michaël Radkë, Christina Hauenstein, Carsten H. G. Müller et autres

Intramural duodenal hematoma (IDH) in children is a rare complication after esophagogastroduodenoscopy. It is commonly described in patients with additional disorders or risk factors, such as coagulopathy. We present a case of a previously healthy 6-year-old boy with a large obstructing intramural …

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