Jianlin Ma

High-throughput single-cell screening of a cross-lineage CAR library for early-stage CAR design and candidate discovery

Hairong Jing, Dan Yuan, Bangquan Ye, Jianlin Ma et autres

Chimeric antigen receptor T cell therapy (CAR-T) has demonstrated promising efficacy in hematological malignancies, but translating that success to solid tumors remains challenging. Here, we construct a CAR library comprising approximately 1000 variants targeting prostate-specific membrane antigen by recombining transmembrane (TM), co-stimulatory, …

cn (code pays fourni par la source)

High-throughput single-cell screening of a cross-lineage CAR library for early-stage CAR design and candidate discovery

Hairong Jing, Dan Yuan, Bangquan Ye, Jianlin Ma et autres

Chimeric antigen receptor T cell therapy (CAR-T) has demonstrated promising efficacy in hematological malignancies, but translating that success to solid tumors remains challenging. Here, we construct a CAR library comprising approximately 1,000 variants targeting prostate-specific membrane antigen by recombining transmembrane (TM), co-stimulatory, …

cn (code pays fourni par la source)

High and selective cytotoxicity of ex vivo expanded allogeneic human natural killer cells from peripheral blood against bladder cancer: implications for natural killer cell instillation after transurethral resection of bladder tumor

Fangming Wang, Gang Zhang, Tianli Xu, Jianlin Ma et autres

BACKGROUND: Non-muscle-invasive bladder cancer (NMIBC) is treated with transurethral resection of bladder tumor (TURBT) followed by intravesical instillation of chemotherapy or Bacillus Calmette-Guérin therapy. However, these treatments have a high recurrence rate and side effects, emphasizing the need for alternative instillations. Previously, …

cn, us (code pays fourni par la source)

TIGIT immune checkpoint blockade enhances immunity of human peripheral blood NK cells against castration-resistant prostate cancer

Fangming Wang, Shuai Liu, Fei Liu, Tianli Xu et autres

cn, us (code pays fourni par la source)

Preclinical study of human umbilical cord mesenchymal stem cell sheets for the recovery of ischemic heart tissue

Shuang Gao, Yongqiang Jin, Jianlin Ma, Juan Wang et autres

BACKGROUND: Human umbilical cord mesenchymal stem cells (hUC-MSCs) have been widely used due to their multipotency, a broad range of sources, painless collection, and compliance with standard amplification. Cell sheet technology is a tissue engineering methodology requiring scaffolds free, and it provides …

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Allogeneic Expanded Human Peripheral NK Cells Control Prostate Cancer Growth in a Preclinical Mouse Model of Castration-Resistant Prostate Cancer

Fangming Wang, Xuejiao Dong, Jing Wang, Feiya Yang et autres

Adoptive allogeneic natural killer (NK) cell therapy has shown promise in treating castration-resistant prostate cancer (CRPC), which is the terminal stage of prostate cancer (PCa) and incurable. Thus, we employed an efficient manufacturing method for the large-scale ex vivo expansion of high-quality …

cn, jp (code pays fourni par la source)