Inmaculada Docio

Pulmonary Vascular Responses to Chronic Intermittent Hypoxia in a Guinea Pig Model of Obstructive Sleep Apnea

Elena Olea, Esther Valverde‐Pérez, Inmaculada Docio, Jesús Prieto‐Lloret et autres

Experimental evidence suggests that chronic intermittent hypoxia (CIH), a major hallmark of obstructive sleep apnea (OSA), boosts carotid body (CB) responsiveness, thereby causing increased sympathetic activity, arterial and pulmonary hypertension, and cardiovascular disease. An enhanced circulatory chemoreflex, oxidative stress, and NO signaling …

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Pulmonary Vascular Responses to Chronic Intermittent Hypoxia in a Guinea Pig Model of Obstructive Sleep Apnea

Elena Olea, Esther Valverde‐Pérez, Inmaculada Docio, Jesús Prieto‐Lloret et autres

Experimental evidence suggests that chronic intermittent hypoxia (CIH), a major hallmark of obstructive sleep apnea (OSA), boosts carotid body (CB) responsiveness, thereby causing in-creased sympathetic activity, arterial and pulmonary hypertension, and cardiovascular disease. An enhanced circulatory chemoreflex, oxidative stress, and NO signaling …

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Maladaptive Pulmonary Vascular Responses to Chronic Sustained and Chronic Intermittent Hypoxia in Rat

Jesús Prieto‐Lloret, Elena Olea, Ana Gordillo-Cano, Inmaculada Docio et autres

Chronic sustained hypoxia (CSH), as found in individuals living at a high altitude or in patients suffering respiratory disorders, initiates physiological adaptations such as carotid body stimulation to maintain oxygen levels, but has deleterious effects such as pulmonary hypertension (PH). Obstructive sleep …

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Peripheral Dopamine 2-Receptor Antagonist Reverses Hypertension in a Chronic Intermittent Hypoxia Rat Model

Elena Olea, Inmaculada Docio, Miguel Quintero, Asunción Rocher et autres

patterns. In both situations, chronic intermittent hypoxia (CIH) exposure produces carotid body (CB) hyperactivation generating an increased input to the brainstem which originates sympathetic hyperactivity, followed by hypertension that is abolished by CB denervation. CB has dopamine (DA) receptors in chemoreceptor cells …

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Gender influence on carotid body sensitization and pulmonary arterial hypertension in chronic hypoxic rats

Elena Olea, Jesús Prieto‐Lloret, Ana Gordillo, Inmaculada Docio et autres

Trabajo presentado al XXXIX Congreso de la Sociedad Española de Ciencias Fisiológicas (SECF), celebrado en Cádiz del 18 al 21 de septiembre de 2018.

Maladaptive Pulmonary vascular responses to chronic intermittent and sustained hypoxia in a rat hypertension model

Asunción Rocher, Jesús Prieto‐Lloret, Inmaculada Docio, Elena Olea et autres

Rationale & Aim: Chronic sustained hypoxia (CSH) initiates physiological adaptations to maintain oxygen levels but also has deleterious effects as pulmonary hypertension (PH). Chronic intermittent hypoxia (CIH), as found in obstructive sleep apnea, is associated with the development of systemic hypertension and …

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Chronic Intermittent Hypoxia effects are not mediated by guinea pig carotid body sensitization

Ángela Gómez-Niño, Inmaculada Docio, Elena Olea, Jesús Prieto‐Lloret et autres

Rationale & Aim: Experimental evidences indicate a correlation among chronic intermittent hypoxia (CIH), increased carotid body (CB) activity, enhanced sympatho-respiratory coupling and arterial hypertension. The recurrent hypoxia/reoxygenation episodes in CIH models produce CB sensitization increasing secretory response and chemoreceptor input to the …

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Guinea Pig as a Model to Study the Carotid Body Mediated Chronic Intermittent Hypoxia Effects

Inmaculada Docio, Elena Olea, Jesús Prieto‐Lloret, Teresa Gallego‐Martin et autres

Clinical and experimental evidence indicates a positive correlation between chronic intermittent hypoxia (CIH), increased carotid body (CB) chemosensitivity, enhanced sympatho-respiratory coupling and arterial hypertension and cardiovascular disease. Several groups have reported that both the afferent and efferent arms of the CB chemo-reflex …

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Estrogens and age influence on pulmonary hypertension in female rats

Elena Olea, Asunción Rocher, Inmaculada Docio, Ángela Gómez-Niño et autres

Trabajo presentado en la 2ª Reunión de investigación en hipertensión pulmonar, celebrado en Madrid (España) el 2 de febrero de 2018.

Mitochondrial Complex I Dysfunction and Peripheral Chemoreflex Sensitivity in a FASTK-Deficient Mice Model

Ángela Gómez-Niño, Inmaculada Docio, Jesús Prieto‐Lloret, Marı́a Simarro et autres

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Physiopathological cardiorespiratory responses to two chronic hypoxic treatments in rats

Ana Gordillo Cano, Marta Ayllón, Jesús Prieto‐Lloret, Inmaculada Docio et autres

Trabajo presentado a las 11as Jornadas de Formacion del CIBERES (Jornadas conjuntas con CIBERONC), celebradas en el Instituto de Salud Carlos III (Madrid) del 15 al 16 de noviembre de 2018.

Role of reactive oxygen species and sulfide-quinone oxoreductase in hydrogen sulfide-induced contraction of rat pulmonary arteries

Jesús Prieto‐Lloret, Vladimir A. Snetkov, Yasin Shaifta, Inmaculada Docio et autres

Application of H2S (“sulfide”) elicits a complex contraction in rat pulmonary arteries (PAs) comprising a small transient contraction (phase 1; Ph1) followed by relaxation and then a second, larger, and more sustained contraction (phase 2; Ph2). We investigated the mechanisms causing this …

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