Zongcai Liu

Acetylation-stabilized METTL3 drives anti-PD-1 resistance in lung cancer by promoting CD8+ T cell exhaustion via SPP1 translation

Haifang Wang, Wen Zhang, Hao Liu, Fen Ning et autres

Anti-programmed cell death protein 1 (anti-PD-1) therapy is a standard treatment for advanced lung cancer, but its efficacy is often limited by resistance, driven largely by an immunosuppressive tumor microenvironment. Methyltransferase-like 3 (METTL3), a core N6-methyladenosine (m 6 A) writer, plays a …

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Supplementary Figure 2 from METTL14-Mediated Bim mRNA m6A Modification Augments Osimertinib Sensitivity in EGFR-Mutant NSCLC Cells

Siwen Fan, Xinwu Lv, Chuantao Zhang, Bingbing Zeng et autres

S2. The effect of METTL14 knockdown on cell proliferation of H1975 and PC9 cells.

Supplementary Figure 6 from METTL14-Mediated Bim mRNA m6A Modification Augments Osimertinib Sensitivity in EGFR-Mutant NSCLC Cells

Siwen Fan, Xinwu Lv, Chuantao Zhang, Bingbing Zeng et autres

S6. METTL14-mediated m6A methylation of Bim mRNA maintains its stability and increases Bim expression.

Supplementary Figure 1 from METTL14-Mediated Bim mRNA m6A Modification Augments Osimertinib Sensitivity in EGFR-Mutant NSCLC Cells

Siwen Fan, Xinwu Lv, Chuantao Zhang, Bingbing Zeng et autres

S1. The validation of resistance to third-generation TKIs osimertinib, furmonertinib and almonertinib in osimertinib-resistant NSCLC cells.

Supplementary Figure 5 from METTL14-Mediated Bim mRNA m6A Modification Augments Osimertinib Sensitivity in EGFR-Mutant NSCLC Cells

Siwen Fan, Xinwu Lv, Chuantao Zhang, Bingbing Zeng et autres

S5. METTL14 promotes cell apoptosis in NSCLC cells.

Supplementary Figure 7 from METTL14-Mediated Bim mRNA m6A Modification Augments Osimertinib Sensitivity in EGFR-Mutant NSCLC Cells

Siwen Fan, Xinwu Lv, Chuantao Zhang, Bingbing Zeng et autres

S7. The effect of METTL3 on m6A-modified Bim mRNA.

Supplementary Figure 3 from METTL14-Mediated Bim mRNA m6A Modification Augments Osimertinib Sensitivity in EGFR-Mutant NSCLC Cells

Siwen Fan, Xinwu Lv, Chuantao Zhang, Bingbing Zeng et autres

S3. The effect of METTL3 on the osimertinib sensitivity of NSCLC cells.

Supplementary Figure 4 from METTL14-Mediated Bim mRNA m6A Modification Augments Osimertinib Sensitivity in EGFR-Mutant NSCLC Cells

Siwen Fan, Xinwu Lv, Chuantao Zhang, Bingbing Zeng et autres

S4. METTL14 promotes osimertinib-induced cell apoptosis in NSCLC cells.

Octanoic acid treatment alleviates cold-induced depression-like behaviors via targeting the AKR1B1-PGF2α pathway

Zongcai Liu, Jingyu Tan, Sijin Zhu, Zhiwei Zhao et autres

Environmental factors play a crucial role in the onset and progression of negative mood. Low temperature, an important environmental factor, acutely induces negative mood and increases depression risk. However, mechanisms underlying low temperature-induced negative mood and its prevention remain unclear. Here, we …

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Clinical outcomes of transcatheter arterial embolization in patients with angiography-negative duodenal ulcer bleeding after failed endoscopic hemostasis

Shoulin Zhang, Zongcai Liu, Zezhong Gong, Yanyang Wu et autres

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Myeloid‐Derived Suppressor Cells in Cancer: Mechanistic Insights and Targeted Therapeutic Innovations

Tian Shou Hu, Jianxue Zhai, Jiajia Peng, Chuxuan Wang et autres

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that expand aberrantly in cancer and exhibit potent immunosuppressive properties. They contribute to tumor progression through both immunological and nonimmunological mechanisms. Immunologically, MDSCs suppress antitumor responses by inhibiting effector cells …

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Evaluation of efficacy and safety of AAV8-ΔC4ATP7B gene therapy in a mutant mouse model of Wilson’s disease

Chunhua Zeng, Yunting Lin, Xinshuo Lu, Shehong Chen et autres

Wilson's disease (WD) is an autosomal recessive disorder caused by pathogenic variants in the ATP7B gene, resulting in the toxic accumulation of copper (Cu). Impaired Cu homeostasis in WD is characterized by low serum ceruloplasmin, excess hepatic Cu, and elevated urinary Cu. …

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