Vincent Launay

Nivolumab with or without vinblastine for first-line treatment of elderly patients with Hodgkin lymphoma and coexisting medical conditions: the Niviniho phase II Lysa study

Julien Lazarovici, Sandy Amorim, Krimo Bouabdallah, Marguerite Fournier et autres

The prognosis of elderly patients with Hodgkin lymphoma (HL) unfit for conventional chemotherapy remains poor. We report the results of the LYSA phase II NIVINIHO trial in treatment-naive HL patients aged ≥ 61 years with comorbidities contraindicating standard chemotherapy. Treatment included an …

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Myeloid landscape profiling identifies DLBCL-specific suppressive macrophages colocalized with blood endothelial cells

Juliette Ferrant, Simon Le Gallou, Francine Padonou, Charlotte Dubec‐Fleury et autres

ABSTRACT: Diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) are the 2 most common B-cell lymphomas and are characterized by a dynamic crosstalk between tumor B cells and a heterogeneous, tumor-supportive microenvironment, such as immune, endothelial, and stromal components. Despite their …

fr, us (code pays fourni par la source)

Efficacy of ruxolitinib in the treatment of relapsed/refractory large granular lymphocytic leukaemia

Tony Marchand, Cédric Pastoret, Gandhi Laurent Damaj, Angélique Lebouvier et autres

Large granular lymphocytic (LGL) leukaemia is a rare chronic lymphoproliferative disorder characterized by an expansion of cytotoxic T or NK cells. Despite a usually indolent evolution, most patients will require a treatment over the course of the disease because of cytopenia or …

fr, se (code pays fourni par la source)

Final results on effectiveness and safety of Ibrutinib in patients with chronic lymphocytic leukemia from the non-interventional FIRE study

Caroline Dartigeas, Anne Quinquenel, Loïc Ysebaert, Marie‐Sarah Dilhuydy et autres

We conducted an observational study (FIRE) to understand the effectiveness and safety outcomes of ibrutinib in patients with chronic lymphocytic leukemia (CLL) in France, after a maximum follow-up of five years. Patients were included according to the French marketing authorization in 2016 …

fr (code pays fourni par la source)

Communes petitionum Britonum. Les enquêtes royales de 1235 : outil de réparation judiciaire ou instrument de communication politique ?

Vincent Launay

International audience

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Challenges for quality and utilization of real-world data for diffuse large B-cell lymphoma in REALYSA, a LYSA cohort

Hervé Ghesquières, Fanny Cherblanc, Aurélien Belot, Sophie Micon et autres

ABSTRACT: Real-world data (RWD) are essential to complement clinical trial (CT) data, but major challenges remain, such as data quality. REal world dAta in LYmphoma and Survival in Adults (REALYSA) is a prospective noninterventional multicentric cohort started in 2018 that included patients …

fr, ch (code pays fourni par la source)

Quality of life and response shift effect of diffuse large B‐cell lymphoma French patients included in prospective real‐life REALYSA cohort in the first year after diagnosis

Amélie Anota, Marco Basset, A. Belot, Francesco Cottone et autres

Introduction: Few quality of life (QoL) data are available for diffuse large B-cell lymphoma (DLBCL) patients during the first year of diagnosis. Due to the disease and treatment, patients can adapt to their condition and then change their criteria to assess QoL …

fr, it (code pays fourni par la source)

Randomized Phase III Trial Evaluating Subcutaneous Rituximab for the First-Line Treatment of Low–Tumor Burden Follicular Lymphoma: Results of a LYSA Study

Guillaume Cartron, Emmanuel Bachy, Hervé Tilly, Nicolas Daguindau et autres

PURPOSE Rituximab improves progression-free survival (PFS) and time to next treatment (TTNT) when compared with the watch and wait strategy for patients with low–tumor burden follicular lymphoma (FL). Prolonged rituximab maintenance did not prolong TTNT, whereas it raises concerns about resources use …

fr, be (code pays fourni par la source)

Single-Cell Profiling Identifies Clinically Relevant Interactions Between Tumor Associated Macrophages and Blood Endothelial Cells in Diffuse Large B Cell Lymphoma

Juliette Ferrant, Simon Le Gallou, Francine Padonou, Simon Léonard et autres

fr (code pays fourni par la source)

Chapitre VIII. Les Bretons dans les guerres des derniers Capétiens : l’intégration dans l’appareil militaire du roi

Vincent Launay

Dès le début du xiiie siècle, le duc de Bretagne engage ses troupes aux côtés de celles du roi de France contre les Plantagenêts. Même quand Pierre de Dreux s’allie au roi d’Angleterre contre Louis IX, une large part de la noblesse …

Sources

Vincent Launay

Sources diplomatiques Fonds d’archives bretons Archives départementales des Côtes-d’Armor Série HH 420 : Prieuré Saint-Magloire de LéhonH 423/1 : Prieuré Saint-Malo de DinanH 423/2 : Prieuré Saint-Martin de LamballeH 423/3 : Prieuré Notre-Dame de Jugon Archives départementales d’Ille-et-Vilaine Série 1 F : …

Remerciements

Vincent Launay

Cet ouvrage, qui se veut une version remaniée de la seconde partie d’une thèse d’histoire médiévale soutenue à l’université Rennes 2 le 16 novembre 2017, n’aurait pu voir le jour sans le concours d’une multitude d’acteurs à qui je dois tant. Fruit …