Aref Hosseini

Mitochondrial Dysfunction Rewires Macrophage Metabolism, Driving Pro-inflammatory Priming and Immune System Remodeling

Nikita Markov, Aref Hosseini, Timothée Fettrelet, Kevin Oberson et autres

Abstract Macrophage activation is tightly coupled to cellular metabolism: classically activated pro-inflammatory (M1) macrophages rely on glycolysis and a disrupted tricarboxylic acid cycle, whereas alternatively activated (M2) macrophages depend on oxidative phosphorylation (OXPHOS) and fatty acid oxidation. Although mitochondria are central to …

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Evidence for a Role of the Long Non-Coding RNA ITGB2-AS1 in Eosinophil Differentiation and Functions

Timothée Fettrelet, Aref Hosseini, Jacqueline Wyss, Joanna Boros-Majewska et autres

Eosinophils, a type of granulocyte derived from myeloid precursors in the bone marrow, are distinguished by their cytoplasmic granules. They play crucial roles in immunoregulation, tissue homeostasis, and host defense, while also contributing to the pathogenesis of various inflammatory diseases. Although long …

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The BK Channel Limits the Pro-Inflammatory Activity of Macrophages

Yihe Chen, Nikita Markov, Lea Gigon, Aref Hosseini et autres

Macrophages play a crucial role in the innate immune response, serving as key effector cells in the defense against pathogens. Although the role of the large-conductance voltage and calcium-activated potassium channel, also known as the KCa1.1 or BK channel, in regulating neurotransmitter …

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A Multicenter Long-Term Cohort Study of Eosinophilic Esophagitis Variants and Their Progression to Eosinophilic Esophagitis Over Time

Thomas Greuter, Alex Straumann, Yuniel Fernández‐Marrero, Nina Germič et autres

INTRODUCTION: Eosinophilic esophagitis (EoE) variants have been recently characterized as conditions with symptoms of esophageal dysfunction resembling EoE, but absence of significant esophageal eosinophilia. Their disease course and severity have yet to be determined. METHODS: Patients from 6 EoE centers with symptoms …

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The regulatory role of eosinophils in adipose tissue depends on autophagy

Aref Hosseini, Nina Germič, Nikita Markov, Darko Stojkov et autres

Introduction Obesity is a metabolic condition that elevates the risk of all-cause mortality. Brown and beige adipose tissues, known for their thermogenic properties, offer potential therapeutic targets for combating obesity. Recent reports highlight the role of immune cells, including eosinophils, in adipose …

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Transcriptional Insights of Oxidative Stress and Extracellular Traps in Lung Tissues of Fatal COVID-19 Cases

Aref Hosseini, Darko Stojkov, Timothée Fettrelet, Rostyslav O. Bilyy et autres

Neutrophil extracellular traps (NETs) and oxidative stress are considered to be beneficial in the innate immune defense against pathogens. However, defective clearance of NETs in the lung of acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients could lead to severe respiratory syndrome infection, …

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Twin-free cliques in annihilator graphs of commutative rings

N. Kh. Tohidi, Aref Hosseini, R. Nikandish

For a connected graph [Formula: see text] a clique [Formula: see text] is twin-free if every pair of elements of [Formula: see text] have distinct closed neighborhoods and the number of elements in a twin-free clique of maximum cardinality is called twin-free …

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Sa1182: LONGITUDINAL FOLLOW-UP OF PATIENTS WITH EOSINOPHILIC ESOPHAGITIS VARIANTS AND THEIR POTENTIAL TO PROGRESS TO EOE: A CLINICAL, HISTOLOGICAL AND MOLECULAR MULTI-CENTER ANALYSIS

Thomas Greuter, Alex Straumann, Yuniel Fernández‐Marrero, Nina Germič et autres

Characterization of eosinophilic esophagitis variants by clinical, histological, and molecular analyses: A cross‐sectional multi‐center study

Thomas Greuter, Alex Straumann, Yuniel Fernández‐Marrero, Nina Germič et autres

OBJECTIVE: Physicians are increasingly confronted with patients presenting with symptoms of esophageal dysfunction resembling eosinophilic esophagitis (EoE), but absence of significant esophageal eosinophilia. The purpose of this study was to characterize and classify this group of EoE variants. DESIGN: (<15/hpf) in esophageal …

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ATG5 promotes eosinopoiesis but inhibits eosinophil effector functions

Nina Germič, Aref Hosseini, Darko Stojkov, Kevin Oberson et autres

Eosinophils are white blood cells that contribute to the regulation of immunity and are involved in the pathogenesis of numerous inflammatory diseases. In contrast to other cells of the immune system, no information is available regarding the role of autophagy in eosinophil …

Regulation of eosinophil functions by autophagy

Nina Germič, Aref Hosseini, Shída Yousefi, Alexander Viktorovich Karaulov et autres

Eosinophils are granule-containing leukocytes which develop in the bone marrow. For many years, eosinophils have been recognized as cytotoxic effector cells, but recent studies suggest that they perform additional immunomodulatory and homeostatic functions. Autophagy is a conserved intracellular process which preserves cellular …

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ATG5 promotes eosinopoiesis but inhibits eosinophil effector functions

Nina Germič, Aref Hosseini, Darko Stojkov, Kevin Oberson et autres

Eosinophils are white blood cells that contribute to the regulation of immunity and are involved in the pathogenesis of numerous inflammatory diseases. In contrast to other cells of the immune system, no information is available regarding the role of autophagy in eosinophil …

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