Arineh Khechaduri

Diverse germline-targeting HIV Env immunogens select for distinct mutations in the same knock-in mice B cell receptors

Parul Agrawal, Junli Feng, Latha Kallur Siddaramaiah, Arineh Khechaduri et autres

VRC01-class HIV broadly neutralizing antibodies have been isolated from people living with HIV. Their unmutated (germline) forms do not bind Env and do not neutralize HIV. They acquire their broadly neutralizing potentials through the accumulation of specific somatic mutations. Here, we identify …

Afrique du Sud, us (code pays fourni par la source)

Self-amplifying RNA-based activation of HIV-1 broadly neutralizing antibody B cell precursors 2690

Parul Agrawal, Madison M. Means, Karli Hinton, Arineh Khechaduri et autres

Abstract Description Elicitation of broadly HIV neutralizing antibody (Ab) responses requires sequential immunizations with specifically designed HIV Env-derived proteins. Such constructs are presently in pre-clinical and clinical evaluation, but the production of multiple immunogens is costly, and the implementation of prolonged immunization …

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Increased immunogen valency improves the maturation of vaccine-elicited HIV-1 VRC01-like antibodies

Parul Agrawal, Arineh Khechaduri, Kelsey R. Salladay, Anna J. MacCamy et autres

Antibodies belonging to the VRC01-class display broad and potent neutralizing activities and have been isolated from several people living with HIV (PLWH). A member of that class, monoclonal antibody VRC01, was shown to reduce HIV-acquisition in two phase 2b efficacy trials. VRC01-class …

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Cell-type specific global reprogramming of the transcriptome and epigenome in induced neurons with the 16p11.2 neuropsychiatric CNVs

Thomas Ward, Pingping Qu, Louis C. Leung, Bo Zhou et autres

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Increased immunogen valency improves the maturation of vaccine-elicited HIV-1 VRC01-class antibodies

Parul Agrawal, Arineh Khechaduri, Kelsey R. Salladay, Anna J. MacCamy et autres

ABSTRACT Antibodies belonging to the VRC01-class display broad and potent neutralizing activities and have been isolated from several people living with HIV (PLWH). A member of that class, monoclonal antibody VRC01, was shown to reduce HIV-acquisition in two phase 2b efficacy trials. …

Afrique du Sud, us (code pays fourni par la source)

Short CDRL1 in intermediate VRC01-like mAbs is not sufficient to overcome key glycan barriers on HIV-1 Env

Parul Agrawal, Maria L. Knudsen, Anna J. MacCamy, Nicholas K. Hurlburt et autres

VRC01-class broadly neutralizing antibodies (bnAbs) have been isolated from people with HIV-1, but they have not yet been elicited by vaccination. They are extensively somatically mutated and sometimes accumulate CDRL1 deletions. Such indels may allow VRC01-class antibodies to accommodate the glycans expressed …

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Cell-type specific global reprogramming of the transcriptome and epigenome in induced neurons with the 16p11.2 neuropsychiatric CNVs

Xianglong Zhang, Thomas Ward, Louis C. Leung, Pingping Qu et autres

Abstract Copy number variants (CNVs), either deletions or duplications, at the 16p11.2 locus in the human genome are known to increase the risk for autism spectrum disorders (ASD), schizophrenia, and several other developmental conditions. Here, we investigate the global effects on gene …

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Adjuvants influence the maturation of VRC01-like antibodies during immunization

Maria L. Knudsen, Parul Agrawal, Anna J. MacCamy, K. Rachael Parks et autres

Once naive B cells expressing germline VRC01-class B cell receptors become activated by germline-targeting immunogens, they enter germinal centers and undergo affinity maturation. Booster immunizations with heterologous Envs are required for the full maturation of VRC01-class antibodies. Here, we examined whether and …

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Adjuvants influence the maturation of VRC01-like antibodies during immunization

Maria L. Knudsen, Parul Agrawal, Anna J. MacCamy, K. Rachael Parks et autres

ABSTRACT Once naïve B cells expressing germline VRC01-class B cell receptors become activated by germline-targeting immunogens, they enter germinal centers and undergo affinity maturation. Booster immunizations with heterologous Envs are required for the full maturation of VRC01-class antibodies. Here, we examined whether …

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HIV-1 VRC01 Germline-Targeting Immunogens Select Distinct Epitope-Specific B Cell Receptors

Yu‐Ru Lin, K. Rachael Parks, Connor E. Weidle, Anika S. Naidu et autres

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Genome-wide molecular effects of the neuropsychiatric 16p11 CNVs in an iPSC-to-iN neuronal model

Thomas Ward, Xianglong Zhang, Louis C. Leung, Bo Zhou et autres

Abstract Copy number variants (CNVs), either deletions or duplications, at the 16p11.2 locus in the human genome are known to increase the risk for autism spectrum disorders (ASD), schizophrenia, and for several other developmental conditions. Here, we investigate the global effects on …

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Epigenetic signatures of attachment insecurity and childhood adversity provide evidence for role transition in the pathogenesis of perinatal depression

Thalia K. Robakis, Siming Zhang, Natalie Rasgon, Tongbin Li et autres

Abstract Early life adversity and insecure attachment style are known risk factors for perinatal depression. The biological pathways linking these experiences, however, have not yet been elucidated. We hypothesized that overlap in patterns of DNA methylation in association with each of these …

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