Karel Zadrobílek

Serum neurofilament light chain in hydrocephalus and surgical controls: baseline comparison and 24-hour perioperative dynamics under general anesthesia

Miroslav Cihlo, Pavel Trávníček, Alena Tichá, Radomír Hyšpler et autres

Background/Objectives neurofilament light chain (NfL) is a blood-accessible marker of neuroaxonal injury. We assessed the clinical utility of serum NfL in adults with idiopathic normal-pressure hydrocephalus (iNPH). Methods in a single-center prospective cohort (registered at ClinicalTrials.gov; partial overlap with a prior registry …

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Value of biomarkers in the prediction of shunt responsivity in patients with normal pressure hydrocephalus

Miroslav Cihlo, Pavel Trávníček, Alena Tichá, Radomı́r Hyšpler et autres

Preoperative differentiation between responders and non-responders to ventriculoperitoneal (VP) shunting in the treatment of normal pressure hydrocephalus (NPH) remains a significant challenge. Identifying biomarkers in presurgical assessment represents a promising approach to reducing the need for invasive cerebrospinal fluid CSF testing. In …

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Value of Biomarkers in the Prediction of Shunt Responsivity in Patients with Normal Pressure Hydrocephalus

Miroslav Cihlo, Pavel Trávníček, Alena Tichá, Radomı́r Hyšpler et autres

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Utilization of a Telemetric Prechamber in the Management of Patients with Normal Pressure Hydrocephalus

Miroslav Cihlo, P. Trávnı́ček, S Rehák, Lucie Kukrálová et autres

Normal pressure hydrocephalus is a preventable and treatable cause of dementia. A telemetric prechamber allows individually tailored ventriculoperitoneal shunt valve adjustments in patients treated with the shunting procedure. In this pilot, prospective randomized trial, 33 adult patients were divided into Group A …

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The Need for Emphasis on Intracranial Hypertension Management in Spontaneous Skull Base Meningoencephaloceles

Pavel Póczoš, Miroslav Cihlo, Karel Zadrobílek, Jiří Jandura et autres

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Intracranial hypertension management in spontaneous skull base meningoencephaloceles

Pavel Póczoš, Miroslav Cihlo, Karel Zadrobílek, Jiří Jandura et autres

Abstract Spontaneous meningoencephaloceles are often associated with cerebrospinal fluid leak and intracranial hypertension. There is a data scarcity concerning the need for insertion of a cerebrospinal diversion device in these situations. Therefore, we provided an analysis of our patients with spontaneous skull …

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Grisel’s syndrome – case report

Nicol Kossuthová, Jan Mejzlík, Karel Zadrobílek, Jana Dědková et autres

Introduction: By definition from the literature, Grisel’s syndrome is described as non-traumatic rotational atlantoaxial instability between C1 and C2 vertebrae. It can occur during an infection of a soft tissue in the cervicocranial region or after an operation in the ENT region. …

Back injures and spinal fractures

Radek Štichhauer, Miroslav Cihlo, Antonín Šafus, Karel Zadrobílek et autres

Úrazy zad a páteře jsou heterogenní skupina poranění, se kterou se setkávají lékaři dětských pacientů téměř každý den. Článek je shrnutím přístupu k vyšetření a ošetření nejběžnějších poranění páteře z pohledu chirurgických pracovišť Fakultní nemocnice v Hradci Králové. Současně se snaží navrhnout …

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The routes of infection spread in central skull-base osteomyelitis and the diagnostic role of CT and MRI scans

Jan Mejzlík, Lucie Zeinerová, Jana Dědková, Jan Kopřiva et autres

BACKGROUND: Central skull-base osteomyelitis (CSBO) represents a life-threatening complication of external ear canal infection. Computed tomography (CT) and magnetic resonance imaging (MRI) play key roles in assessment of CSBO progression. METHODS: Twelve patients with CSBO were included in a retrospective clinical study. …

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