Shinya Oh-hashi

Effects of Erythropoietin Treatment on Thyroid Dysfunction in Hemodialysis Patients with Renal Anemia

Fumihiro Tomoda, Masanobu Takata, Kiyoshi Izumino, Shinya Oh-hashi et autres

The thyroid function was evaluated before and after 6 months of recombinant human erythropoietin (rhEPO) treatment (1,500-9,000 U/week) in 22 hemodialysis patients with hematocrit levels < 25%. Based upon the changes in hematocrit following rhEPO treatment, the patients were divided into two …

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Book Reviews

Raymond Ardaillou, Jean‐Claude Dussaule, Mitchell L. Halperin, Surinder Cheema‐Dhadli et autres

Time Course of the Effects of Temocapril on Cardiovascular Structure and Function in Patients with Essential Hypertension

Masanobu Takata, Hitoshi Ueno, Tadakazu Hirai, Shinya Oh-hashi et autres

To investigate the time course of cardiovascular structural changes in patients with essential hypertension after angiotensin-converting enzyme (ACE) inhibition, we determined left ventricular structure, minimal vascular resistance in the forearm as an index of resistance vessel structure and stiffness beta of carotid …

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The Effects of Long-Term Treatment on Left Ventricular Hypertrophy in Patients with Essential Hypertension: Relation to Changes in Neurohumoral Factors

Hitoshi Ueno, Masanobu Takata, Shin Tomita, Shinya Oh-hashi et autres

This study compared the effects of 1 year of monotherapy with a calcium-channel antagonist (nilvadipine; NIL), an angiotensin-converting enzyme (ACE) inhibitor (temocapril; TEM), or a new vasodilator (cadralazine; CAD) on left ventricular (LV) hypertrophy in essential hypertension. Furthermore, to elucidate the mechanism …

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Time course of regression of vascular structural changes and its relation to cytosolic free calcium in hypertensives after nilvadipine treatment.

Hitoshi Ueno, Masanobu Takata, Shinya Oh-hashi, Fumihiro Tomoda et autres

The objective of this study was to assess the regression of vascular structural changes seen in essential hypertension after long-term monotherapy with a calcium antagonist and to clarify the relations to cytosolic free calcium and neurohumoral factors. Blood pressure, minimal vascular resistance …

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Diagnostic Value of Captopril Test in Hypertensive Patients with Renal Artery Stenosis

Masanobu Takata, Koshiro Yoshida, Fumihiro Tomoda, Shinya Oh-hashi et autres

To examine the utility of the single-dose captopril test in detecting renovascular hypertension (RVHT), the authors measured peripheral plasma renin activity (PRA), before and thirty and sixty minutes after an oral dose of captopril (25 mg), in 28 patients with RVHT and …

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Regression of vascular structural changes and calcium metabolism in patients with essential hypertension after long-term monotherapy with enalapril.

Hitoshi Ueno, Masanobu Takata, Shinya Oh-hashi, Fumihiro Tomoda et autres

We investigated the effect of one year of enalapril monotherapy on vascular structural changes and calcium metabolism in ten patients with essential hypertension. BP decreased from 169-10/103 +/- 10 mmHg during the placebo period to 138-12/82 +/- 10 mmHg after enalapril therapy. …

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Altered renal response to enhanced endogenous 5-hydroxytryptamine after tryptophan administration in essential hypertension

Fumihiro Tomoda, Masanobu Takata, Shinya Oh-hashi, Hitoshi Ueno et autres

1. To examine the pathophysiological significance of 5-hydroxytryptamine (serotonin) in essential hypertension, we compared the renal response to intrarenally formed 5-hydroxytryptamine by oral dosing with its precursor, L-tryptophan (2 g), in nine patients with essential hypertension and in six subjects with normotension. …

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Cytosolic free calcium concentration in platelets in patients with renovascular hypertension and primary aldosteronism.

Shinya Oh-hashi, Masanobu Takata, Hitoshi Ueno, Fumihiro Tomoda et autres

To investigate the role of cytosolic free calcium, [Ca2+]i, in secondary hypertension, the levels in platelets from 14 secondary hypertensives (7 renovascular hypertension, 7 primary aldosteronism) were compared with those from 21 essential hypertensives and 15 normotensives by means of the fluorescent …

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Altered Renal Response Following an Amino Acid Infusion in Essential Hypertension.

Fumihiro Tomoda, Masanobu Takata, Shinya Oh-hashi, Hitoshi Ueno et autres

To assess the clinical implications of protein load in essential hypertension, we measured renal plasma flow (RPF) and glomerular filtration rate (GFR) at 30-min intervals after initiating 10% amino acid infusion (6.7mg/kg/min for 30min) in 10 untreated patients with essential hypertension and …

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[Studies on drug-induced exanthema].

Shinya Oh-hashi