S.W. Scally

GID/CTLH E3 ligase complex control cell fate programs for sexual development of Plasmodium falciparum

Danushka S. Marapana, Sash Lopaticki, Balu Balan, Kitsanapong Reaksudsan et autres

Transmission of the malaria parasite Plasmodium falciparum requires the formation of specialised sexual cells called gametocytes. A hallmark of P. falciparum gametocyte development is its long duration, during which the parasite undergoes dramatic cellular remodelling including morphological, physiological and metabolic changes which …

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Antibody responses against bacterial glycans affinity mature and diversify in germinal centers

Holly A. Fryer, Catherine Pitt, Hannah R. Frost, Nitika Kandhari et autres

Anti-carbohydrate antibodies (Abs) play crucial roles in pathogen control, but their generation remains poorly understood. Here, we studied how B cell immunity against the Streptococcus pyogenes surface polysaccharide is influenced by age and antigen (Ag) exposure across human blood, spleen, and tonsils. …

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CD44 cross-linking promotes Plasmodium falciparum invasion

Angel K. Kongsomboonvech, S.W. Scally, Yann Le Guen, Praveesh Valissery et autres

The ability of Plasmodium falciparum to invade and replicate asexually within human red blood cells (RBCs) is central to its pathogenicity. Invasion involves several host-parasite interactions, yet the required host factors remain underexplored, largely due to the intractability of mature RBCs. The …

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MK-7602: a potent multi-stage dual-targeting antimalarial

Paola Favuzza, Josephine Palandri, Manuel de Lera Ruiz, Wendy Bailey et autres

BACKGROUND: The global burden of malaria remains substantial, and increasing parasite resistance to current antimalarials necessitates the development of drugs with unique mechanisms of action. This study aimed to develop and characterise a new antimalarial compound targeting Plasmodium aspartic proteases. METHODS: We …

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CD44 cross-linking promotes Plasmodium falciparum invasion

Angel K. Kongsomboonvech, S.W. Scally, Yann Le Guen, Praveesh Valissery et autres

ABSTRACT The ability of the malaria parasite Plasmodium falciparum to invade and replicate asexually within human red blood cells (RBCs) is central to its pathogenicity, accounting for hundreds of thousands of deaths each year. RBC invasion is a multi-step process involving several …

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PTRAMP, CSS and Ripr form a conserved complex required for merozoite invasion of Plasmodium species into erythrocytes

Alan F. Cowman, Benjamin A. Seager, Pailene S. Lim, Lionel Brice Feufack-Donfack et autres

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Antibody responses against bacterial glycans affinity mature and diversify in germinal centers

Holly A. Fryer, Catherine Pitt, Hannah R. Frost, Nitika Kandhari et autres

Summary Anti-carbohydrate antibodies (Abs) play crucial roles in pathogen control, but their generation remains poorly understood. By studying responses to Streptococcus pyogenes in humans, we reveal that the glycan-targeted response shifts from IgM towards IgG and IgA memory with age and antigen …

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PTRAMP, CSS and Ripr form a conserved complex required for merozoite invasion of Plasmodium species into erythrocytes

Benjamin A. Seager, Pailene S. Lim, Keng Heng Lai, Lionel Brice Feufack-Donfack et autres

Summary Invasion of erythrocytes by members of the Plasmodium genus is an essential step of the parasite lifecycle, orchestrated by numerous host-parasite interactions. In P. falciparum Rh5, with PfCyRPA, PfRipr, PfCSS, and PfPTRAMP, forms the essential PCRCR complex which binds basigin on …

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Structure–activity analysis of imino‐pyrimidinone‐fused pyrrolidines aids the development of dual plasmepsin V and plasmepsin X inhibitors

Anthony N. Hodder, Brad E. Sleebs, G. W. Adams, Anna Ngo et autres

A library of known aspartic protease inhibitors was screened to identify compounds that inhibit plasmepsin V from Plasmodium vivax. This screen revealed compounds with an imino-pyrimidinone-fused pyrrolidine (IPF) scaffold that exhibited sub-micromolar inhibitory activity against plasmepsin V. Further screening of IPF analogs …

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Antibody Responses Against Bacterial Glycans Affinity Mature and Diversify in Germinal Centers

Holly A. Fryer, Catherine Pitt, Hannah R. Frost, Nitika Kandhari et autres

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Author response for "Structure–activity analysis of imino‐pyrimidinone‐fused pyrrolidines aids the development of dual plasmepsin V and plasmepsin X inhibitors"

Anthony N. Hodder, Brad E. Sleebs, G. W. Adams, Anna Ngo et autres

Author Correction: Glycosylated nanoparticle-based PfCSP vaccine confers long-lasting antibody responses and sterile protection in mouse malaria model

Julia Ludwig, S.W. Scally, Giulia Costa, Sandro Hoffmann et autres

In this article the author name Anna Obraztsova was incorrectly written as Anna Obraztcova. The original article has been corrected.

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