Restituta Mosha

Sources and transmission dynamics of Campylobacter and Shigella using culture-independent molecular methods in Tanzania (SCAT): a protocol for a prospective observational cohort study

Peter M. Mbelele, Sifaeli Katengu, Erin G. Wettstone, Suporn Pholwat et autres

Introduction: Enteric infections caused by Shigella and Campylobacter species are associated with acute diarrhea as well as enteric dysfunction leading to chronic malnutrition and poor child development. However, interventional studies to reduce exposure to these pathogens have been ineffective, and evidence that …

Tanzanie, us (code pays fourni par la source)

Measles Without Rash During Acute Febrile Illness Surveillance in Tanzania, 2023–2024

Saning’o Lukumay, Domitila Augustino, Queen Saidi Naumanga, Susan F. Payne et autres

BACKGROUND: The leading causes of fever requiring hospital admission in rural sub-Saharan Africa remain understudied, particularly using modern molecular diagnostics. METHODS: We enrolled 258 patients with acute fever (cases) and 48 controls admitted to 1 hospital in Tanzania for 1 year starting …

Tanzanie, us, cn (code pays fourni par la source)

Development of an enteric pathogen multiplex immunoassay to measure antibody responses in blood and saliva for integrated serology applications

Lindsay N. Avolio, Nora Pisanic, Kate L. Kruczynski, William John Moss et autres

us, Tanzanie (code pays fourni par la source)

Impact of azithromycin and nitazoxanide on the enteric infections and child growth: Findings from the Early Life Interventions for Childhood Growth and Development in Tanzania (ELICIT) trial

Godfrey Guga, Eric R. Houpt, Sarah Elwood, Jie Liu et autres

BACKGROUND: Early childhood enteric infection with Shigella/EIEC, enteroaggregative E. coli (EAEC), Campylobacter, and Giardia has been associated with reduced child growth, yet a recent randomized trial of antimicrobial therapy to reduce these infections did not improve growth outcomes. To interrogate this discrepancy, …

Tanzanie, us, cn (code pays fourni par la source)

Rifampin urinary excretion to predict serum targets in children with tuberculosis: a prospective diagnostic accuracy study

Tania A. Thomas, Saning’o Lukumay, Sijia Yu, Prakruti S Rao et autres

Objective Pharmacokinetic variability drives tuberculosis (TB) treatment outcomes but measurement of serum drug concentrations for personalised dosing is inaccessible for children in TB-endemic settings. We compared rifampin urine excretion for prediction of a serum target associated with treatment outcome. Design Prospective diagnostic …

us, Tanzanie, pl, in (code pays fourni par la source)