Pavel Lazarev

X-Ray Diffraction of Collagen-Structured Water Molecules for Cancer Detection

Sasha Murokh, Alexander Alekseev, Viacheslav Kubytskyi, Viacheslav Shcherbakov et autres

Structural biomarkers determined by X-ray scattering of the tissues can complement conventional histopathology and facilitate a fast triage procedure of cancer biopsy samples. It has been shown previously that lipid reflexes can distinguish cancerous from benign samples, except for fibroadenomas. In the …

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Vitacrystallography: Appearance and Development of Cancer-Induced Structural Biomarkers in a Mouse Model

Oleksii Avdieiev, Sergey A. Denisov, Ashkan Ajeer, Lois Adams et autres

Structural biomarkers determined by X-ray scattering of the tissues can complement conventional diagnostics and provide a pathway for early detection of diseases. In the present study, mouse models were utilized to observe the progression of prostate cancer. We induced cancer in the …

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Toward In Vivo Cancer Detection: X-Ray Scattering on Thick Phantom Samples

Viacheslav Kubytskyi, Masroor Khonkhodzhaev, Aika Tanaka, Audrey Nguyen et autres

As the number of new breast cancer cases grows around the world, there is an unmet need for fast, accurate, and low-cost methods of early cancer detection. It was previously shown that X-ray scattering on lipid molecules can provide the necessary structural …

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Benign/Cancer Diagnostics Based on X-Ray Diffraction: Comparison of Data Analytics Approaches

Alexander Alekseev, Viacheslav Shcherbakov, Oleksii Avdieiev, Sergey A. Denisov et autres

Background/Objectives: With the number of detected breast cancer cases growing every year, there is a need to augment histopathological analysis with fast preliminary screening. We examine the feasibility of using X-ray diffraction measurements for this purpose; Methods: In this work, we obtained …

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Toward In-Vivo Cancer Detection: X-Ray Scattering on Thick Phantom Samples

Viacheslav Kubytskyi, Masroor Khonkhodzhaev, Aika Tanaka, Audrey Nguyen et autres

As the number of new breast cancer cases grows around the world, there is an unmet need for fast, accurate, and low-cost methods of early cancer detection. It was previously shown that X-ray diffraction on lipid molecules can provide the necessary structural …

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Vitacrystallography: Appearance and Development of Cancer-Induced Structural Biomarkers in a Mouse Model

Oleksii Avdieiev, Sergey A. Denisov, Ash Ajeer, Lois Adams et autres

Structural biomarkers determined by X-ray scattering of the tissues can complement conventional diagnostics and provide a pathway for early detection of diseases. In the present study, mouse models were utilized to observe the progress of prostate cancer. We induced cancer in the …

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Fourier Transformation-Based Analysis of X-Ray Diffraction Pattern of Keratin for Cancer Detection

Alexander Alekseev, Oleksii Avdieiev, Sasha Murokh, Delvin Yuk et autres

With the growing number of cancer cases and deaths around the world, fast, non-invasive, and inexpensive screening is paramount. We examine the feasibility of such cancer detection using the X-ray scattering properties of nails in the canine model. A total of 945 …

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Fourier-Transformation-Based Analysis of X-Ray Diffraction Pattern of Keratin for Cancer Detection

Alexander Alekseev, Oleksii Avdieiev, Sasha Murokh, Delvin Yuk et autres

As the number of cancer cases and deaths growing around the world, fast, non-invasive, and inexpensive screening is paramount. We examine the feasibility of such cancer detection using the X-ray scattering properties of nails in the canine model. 945 samples taken from …

gb, kz, us (code pays fourni par la source)

Fourier-Transformation-Based Analysis of X-Ray Diffraction Pattern of Keratin for Cancer Detection

Alexander Alekseev, Oleksii Avdieiev, Sasha Murokh, Delvin Yuk et autres

We examine the feasibility of non-invasive cancer detection using the X-ray scattering properties of nails in the canine model. 945 samples taken from 266 dogs were measured, with 84 animals diagnosed with cancer. To analyze the obtained X-ray diffraction patterns of keratin, …

X-ray Diffraction Reveals Periodicity in Murine Neocortex

Sasha Murokh, Ezekiel Willerson, А. Ф. Лазарев, Pavel Lazarev et autres

Abstract Background Sensory experience impacts brain development. In the mouse somatosensory cortex, sensory deprivation via whisker trimming induces reductions in the perineuronal net (PNN), the size of neuronal cell bodies, the size and orientation of dendritic arbors, the density of dendritic spines, …

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Vitacrystallography: Structural Biomarkers of Breast Cancer Obtained by X-ray Scattering

Sergey A. Denisov, Benjamin Blinchevsky, Jonathan M. Friedman, Barbara B. Gerbelli et autres

With breast cancer being one of the most widespread causes of death for women, there is an unmet need for its early detection. For this purpose, we propose a non-invasive approach based on X-ray scattering. We measured samples from 107 unique patients …

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Canine Cancer Diagnostics by X-ray Diffraction of Claws

Alexander Alekseev, Delvin Yuk, А. Ф. Лазарев, Daizie Labelle et autres

We report the results of X-ray diffraction (XRD) measurements of the dogs' claws and show the feasibility of using this approach for early, non-invasive cancer detection. The obtained two-dimensional XRD patterns can be described by Fourier coefficients, which were calculated for the …

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