Kelsey J. Moody

Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity

Qiang Fu, Dominika Wilczok, Kejun Ying, Aaron A. King et autres

Aging | doi:10.18632/aging.206135. Yu-Xuan Lyu, Qiang Fu, Dominika Wilczok, Kejun Ying, Aaron King, Adam Antebi, Aleksandar Vojta, Alexandra Stolzing, Alexey Moskalev, Anastasia Georgievskaya, Andrea B. Maier, Andrea Olsen, Anja Groth, Anna Katharina Simon, Anne Brunet, Aisyah Jamil, Anton Kulaga, Asif Bhatti, Benjamin …

cn, de, us, hr, gb, ru, sg, dk, ro, ch, ie, no, nl, hk, gr, au (code pays fourni par la source)

Comparative transport analysis of cell penetrating peptides and Lysosomal sequences for selective tropism towards RPE cells

Kris Grohn, Kyle Parella, Ellie Lumen, Hanna Colegrove et autres

us (code pays fourni par la source)

Interplay of self-organization of microtubule asters and crosslinking protein condensates

Sumon Sahu, Prashali Chauhan, Ellie Lumen, Kelsey J. Moody et autres

The cytoskeleton is a major focus of physical studies to understand organization inside cells given its primary role in cell motility, cell division, and cell mechanics. Recently, protein condensation has been shown to be another major intracellular organizational strategy. Here, we report …

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HOXA3 accelerates wound healing in diabetic and aged non-diabetic mammals

Kyle Parella, Kelsey J. Moody, Danique Wortel, Hanna Colegrove et autres

Chronic wounds are characterized by a persistent, hyper-inflammatory environment that prevents progression to regenerative wound closure. Such chronic wounds are especially common in diabetic patients, often requiring distal limb amputation, but occur in non-diabetic, elderly patients as well. Induced expression of HoxA3, …

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A generalizable nanopore sensor for highly specific protein detection at single-molecule precision

Mohammad Ahmad, Jeung‐Hoi Ha, Lauren Ashley Mayse, Maria F. Presti et autres

Protein detection has wide-ranging implications in molecular diagnostics. Substantial progress has been made in protein analytics using nanopores and the resistive-pulse technique. Yet, a long-standing challenge is implementing specific interfaces for detecting proteins without the steric hindrance of the pore interior. Here, …

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Erratum To: A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A

Matthew S. Simon, Jiping Yang, Jonathan Gigas, Eric J. Earley et autres

Spatially controlled microtubule nucleation and organization from crosslinker MAP65 condensates

Sumon Sahu, Prashali Chauhan, Ellie Lumen, Kelsey J. Moody et autres

Microtubule organization in cells is essential for the internal structure and coordination of events of intracellular transport, mitosis, and cell motility. For many cell types, microtubule organization is dominated by centrosomal nucleation that use gamma-tubulin to template filaments. Yet, some cell types …

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A Generalizable Nanopore Sensor for Highly Specific Protein Detection at Single-Molecule Precision

Mohammad Ahmad, Jeung‐Hoi Ha, Lauren Ashley Mayse, Maria F. Presti et autres

Abstract Protein detection and biomarker profiling have wide-ranging implications in many areas of basic research and molecular diagnostics. Substantial progress has been made in protein analytics using nanopores and the resistive-pulse technique. Yet, a long-standing challenge is implementing specific binding interfaces for …

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A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A

Matthew A. Simon, Jiping Yang, Jonathan Gigas, Eric J. Earley et autres

Sirtuin 6 (SIRT6) is a deacylase and mono‐ADP ribosyl transferase (mADPr) enzyme involved in multiple cellular pathways implicated in aging and metabolism regulation. Targeted sequencing of SIRT6 locus in a population of 450 Ashkenazi Jewish (AJ) centenarians and 550 AJ individuals without …

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Coevolution of the Ess1-CTD axis in polar fungi suggests a role for phase separation in cold tolerance

Ryan J. Palumbo, Nathan McKean, Erinn Leatherman, Kevin E. W. Namitz et autres

Most of the world’s biodiversity lives in cold (−2° to 4°C) and hypersaline environments. To understand how cells adapt to such conditions, we isolated two key components of the transcription machinery from fungal species that live in extreme polar environments: the Ess1 …

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Convergent Alterations of a Protein Hub Produce Divergent Effects within a Binding Site

Ali Imran, Brandon S. Moyer, Dan Kalina, T. Michael Duncan et autres

High Resolution Image Download MS PowerPoint Slide Progress in tumor sequencing and cancer databases has created an enormous amount of information that scientists struggle to sift through. While several research groups have created computational methods to analyze these databases, much work still …

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Exploring the kinetics of the Win-site of WDR5

Ali Imran, Brandon S. Moyer, Ashley J. Canning, Dan Kalina et autres

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