Britta De Pessemier

Multi-omics analyses of facial skin in acne identify distinct microbial and metabolic features at lesional and non-lesional sites

Yang Chen, Britta De Pessemier, Tyler Myers, Simone Zuffa et autres

Abstract The microbial and biochemical landscape of clinically normal-appearing skin in individuals with acne remains uncharacterized. Here, we performed longitudinal multi-omics profiling of facial skin from 10 moderate acne patients and 10 healthy controls, integrating 16S rRNA gene sequencing, shotgun metagenomics, and …

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Multi-omics Analyses of Facial Skin in Acne Identify Distinct Microbial and Metabolic Features at Lesional and Non-lesional Sites

Yang Chen, Britta De Pessemier, Tyler Myers, Simone Zuffa et autres

ABSTRACT The microbial and biochemical landscape of clinically normal-appearing skin in individuals with acne remains uncharacterized. Here, we performed longitudinal multi-omics profiling of facial skin from 10 individuals with moderate acne and 10 healthy controls, integrating 16S rRNA gene sequencing, shotgun metagenomics, …

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Environmental and skin–nasal microbiome variation in South African children with atopic dermatitis

Yang Chen, Nonhlanhla Lunjani, Gillian O. N. Ndhlovu, Drishti Kaul et autres

BACKGROUND: Atopic dermatitis (AD) in early childhood is associated with microbial dysbiosis. Skin and nasal microbiomes have been linked to AD severity; this relationship has not yet been studied in an African cohort. Here, we aimed to explore how urban and rural …

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080 Growth and Biofilm Formation of Malassezia species in an In Vitro Artificial Sebum Model

Britta De Pessemier, M. Verdonck, Karl-Jan Spittaels, Yorick Minnebo et autres

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Environmental and skin–nasal microbiome variation in South African children with atopic dermatitis

Yang Chen, Nonhlanhla Lunjani, Gillian O. N. Ndhlovu, Drishti Kaul et autres

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Chronological age estimation from human microbiomes with transformer-based Robust Principal Component Analysis

Tyler Myers, Se Jin Song, Yang Chen, Britta De Pessemier et autres

Deep learning for microbiome analysis has shown potential for understanding microbial communities and human phenotypes. Here, we propose an approach, Transformer-based Robust Principal Component Analysis(TRPCA), which leverages the strengths of transformer architectures and interpretability of Robust Principal Component Analysis. To investigate benefits …

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LB1189 Growth and biofilm formation potential of Malassezia species in an in vitro artificial sebum model

Britta De Pessemier, M. Verdonck, Karl-Jan Spittaels, Yorick Minnebo et autres

Unravelling the hidden side of laundry: malodour, microbiome and pathogenome

Celia Díez López, Florence Van Herreweghen, Britta De Pessemier, Yorick Minnebo et autres

BACKGROUND: Recent trends towards lower washing temperatures and a reduction in the use of bleaching agents in laundry undoubtedly benefit our environment. However, these conditions impair microbial removal on clothes, leading to malodour generation and negative impacts on consumer well-being. Clothing undergoes …

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Effect of Gut Microbiome on Skin Microbiome

Inge Kortekaas Krohn, Britta De Pessemier, Chris Callewaert

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Multi-omics insights into the skin microbiome of healthy and diseased skin

Britta De Pessemier

De huid is een van de grootste organen van het menselijk lichaam en staat voortdurend in interactie met de omgeving. Ze herbergt een complex microbieel ecosysteem, bestaande uit commensale en opportunistische bacteriën, schimmels, virussen en andere micro-eukaryoten. Dit wordt ook wel onze …

The influence of lifestyle and environmental factors on host resilience through a homeostatic skin microbiota: An EAACI Task Force Report

Inge Kortekaas Krohn, Chris Callewaert, Hafsa Belasri, Britta De Pessemier et autres

Human skin is colonized with skin microbiota that includes commensal bacteria, fungi, arthropods, archaea and viruses. The composition of the microbiota varies at different anatomical locations according to changes in body temperature, pH, humidity/hydration or sebum content. A homeostatic skin microbiota is …

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Comparative Whole Metagenome Analysis in Lesional and Nonlesional Scalp Areas of Patients with Psoriasis Capitis and Healthy Individuals

Britta De Pessemier, Celia Díez López, Steff Taelman, Merel Verdonck et autres

Psoriasis is an immune-mediated inflammatory disorder, where the majority of the patients suffer from psoriasis capitis or scalp psoriasis. Current therapeutics remain ineffective to treat scalp lesions. In this study, we present a whole-metagenome characterization of the scalp microbiome in psoriasis capitis. …

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