2024
conference-abstract
OpenAlex
Jim Palma, Shumei Kato, Mina Nikanjam, Aditya Varnam Shreenivas et autres
3127 Background: Patients (pts) with rare cancers are under-represented in precision medicine trials despite making up ~22% of cancer incidence. We created the TCF-001 TRACK (Target RAre Cancer Knowledge, NCT04504604) study to provide a home-based, patient-centered trial utilizing comprehensive genomic profiling (CGP) …
us
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Harsha Trivedi, Omar Hamdani, Brittani Thomas, J. Mural Richard et autres
OBJECTIVE: To present the characteristics of the AKT1E117K gene variant and a description of the clinical application in a patient with metastatic breast cancer. RESULTS: 63 y/o woman with Stage IV Invasive lobular carcinoma at diagnosis was treated with Palbociclib and aromatase …
us
(code pays fourni par la source)
2020
conference-abstract
OpenAlex
Matthew B.B. Yurgelun, Anu B. Chittenden, Chinedu I. Ukaegbu, Kimberly Perez et autres
678 Background: MGT identifies cancer susceptibility gene variants in 4-10% of unselected PC pts. Such data have prompted national guidelines to recommend GC and MGT of all PC pts, but the benefits and barriers to implementing systematic testing are unknown. This study’s …
us
(code pays fourni par la source)
Accès ouvert
2018
article
OpenAlex
An Xie, Benjamin Paul Gallant, Hao Guo, Alfredo E. Gonzalez et autres
Resting membrane potential (RMP) and intracellular Ca2+ concentration [(Ca2+)i] are involved in tumorigenesis and metastasis. The present study investigated whether functional cardiac Na+ channels are expressed in human melanoma cells (WM 266‑4) and its nonmalignant human melanocytes (HMC), as well as whether …
us, cn
(code pays fourni par la source)
2018
conference-abstract
OpenAlex
Matthew B.B. Yurgelun, Anu B. Chittenden, Chinedu I. Ukaegbu, Tara G. Dhingra et autres
1512 Background: MGT will identify cancer susceptibility gene variants in 4-10% of unselected PC pts. Such data have prompted calls for universal GC and MGT of all PC pts, but the real-world benefits and barriers to implementing such systematic testing are unknown. …
us
(code pays fourni par la source)
Accès ouvert
2017
article
OpenAlex
W. Zhang, Benjamin Paul Gallant, M. Clark, Audrey Madigan et autres
cn, us
(code pays fourni par la source)
Accès ouvert
2017
article
OpenAlex
Huimin Lu, W. Zhang, Benjamin Paul Gallant, M. Clark et autres
cn, us
(code pays fourni par la source)
2017
article
OpenAlex
Audrey Madigan, Benjamin Paul Gallant, Matthew Clark, Yinsheng Wan et autres
Ovarian cancer remains difficult to treat, with the remission rate still high and its drug resistance obvious. Our previous studies have demonstrated that ovarian cancer cells resist chemotherapeutic drugs via activation of EGFR‐PI3K‐AKT mTOR cell survival signaling pathway. Recent studies have suggested …
us, cn
(code pays fourni par la source)
2017
article
OpenAlex
Matthew Clark, Audrey Madigan, Benjamin Paul Gallant, Wei Zhang et autres
In addition to ion transport activities, Na + ‐K + ‐ATPase acts as a cellular signal transduction molecule. Its inhibitors, such as Ouabain, induce the EGFR/ERK pathway as well as the PI3K/AKT pathway. AMPK is involved in cellular metabolism and inhibiting the …
us, cn
(code pays fourni par la source)
2017
article
OpenAlex
Benjamin Paul Gallant, Matthew Clark, Audrey Madigan, Yinsheng Wan et autres
Melanoma is notoriously aggressive and still considered untreatable, in spite of some of the most recent breakthroughs related to immunotherapy. Our previous studies have shown that melanoma cells, compared to untransformed normal human melanocytes, exhibit constitutive mTOR activity and are resistant to …
us, cn
(code pays fourni par la source)
2016
conference-abstract
OpenAlex
Benjamin Paul Gallant, Nicole Lizza, Ryan Garrity, Audrey Madigan et autres
Abstract Transformation from disciplined melanocytes to untamed melanoma cells remains an enigma. Our previous studies have demonstrated that melanoma cells are more resistant to oxidative stress and melanoma cells exhibit constitutive mTOR activity. Surprisingly, further studies have failed to present the expression …
us
(code pays fourni par la source)