Margaret A. Reed

Atroposelective Brønsted Acid-Catalyzed Photocyclization to Access Chiral N-Aryl Quinolones with Low Rotational Barriers

Athimoolam Arunachalampillai, Prashantha Chandrappa, Alan H. Cherney, Richard D. Crockett et autres

-aryl quinolones with low rotational barriers is demonstrated, leveraging a dual photochemical/organocatalytic approach to the required ring closure in up to 94% yield and up to >99% ee. The use of a continuous flow system allows for impurity suppression and enables rapid …

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Neutrophils and secondary infections in COVID-19 induced acute respiratory distress syndrome

Zachary M. Holliday, Mohammed M. Alnijoumi, Margaret A. Reed, Alexander Earhart et autres

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is the cause of the current global pandemic and has affected more than 188 countries worldwide. Infection by the virus can have diverse clinical manifestations, with one of the most severe clinical manifestation being …

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ASP2408 and ASP2409, novel CTLA4-Ig variants with CD86-selective ligand binding activity and improved immunosuppressive potency, created by directed evolution

Shinsuke Oshima, Erik E. Karrer, Madan Paidhungat, Margaret Neighbors et autres

The CTLA4-Ig therapeutics abatacept and belatacept inhibit CD28-mediated T cell activation by binding CD80 (B7-1) and CD86 (B7-2) co-stimulatory ligands. Both compounds preferentially bind CD80, yet CD86 has been implicated as the dominant co-stimulatory ligand. Using directed evolution methods, novel CTLA4-Ig variants …

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Evaluation of Immune Parameters in HIV + Subjects Reporting Adverse Reactions to Sulfamethoxazole

CE O'Neil, Margaret A. Reed, Maite López-Sánchez, N. Hyslop et autres

Trimethoprim-sulfamethoxazole (TMP-SMX) is frequently used in human immunodeficiency virus (HIV)-infected patients (HIV+) for treatment or prophylaxis of Pneumocystis carinii pneumonia (PCP). Up to 80% of those patients report adverse reactions to that drug combination. To test the hypothesis that these reactions are …

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Studies on the Antigenic Composition of Aqueous Cotton Dust Extracts

Carol E. O’Neil, Margaret A. Reed, L. Aukrust, Brian T. Butcher

An immune response to cotton dust components has been proposed as a possible mechanism of byssinosis. To evaluate this possibility, specific precipitating antibodies against aqueous cotton dust extracts (ACDE) were raised in rabbits, and a reference pattern for crossed immunoelectrophoresis (CIE) was …

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News Items

Madeleine Ennis, Cemre Robinson, Colin T. Dollery, Francis B. Casey et autres

Superiority of Solenopsisinvicta Venom to Whole-Body Extract in RAST for Diagnosis of Imported Fire Ant Allergy

Brian T. Butcher, Richard D. deShazo, Ana A. Ortiz, Margaret A. Reed

RAST determinations using imported fire ant (IFA) whole-body extract (IFAWBE) and venom (IFAV) were performed with the sera of 29 sting-sensitive patients. Only 48% (14/29) of sera were positive (percent binding greater than or equal to 6%) in RAST to IFAWBE compared …

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Book Reviews

Gijs H. Boerrigter, Herman Bril, Riekeld J. Scheper, Wan Kim Seow et autres

Author Index

Gijs H. Boerrigter, Herman Bril, Riekeld J. Scheper, Wan Kim Seow et autres

Basidiomycete Allergy: What Is the Best Source of Antigen?

Mandi J. Lopez, Brian T. Butcher, John E. Salvaggio, Jon A. Olson et autres

Skin prick test activity and antigenicity of extracts of in vitro growth of the Basidiomycete Pleurotus ostreatus (PO) were compared to extracts of spores from PO growing in the wild. Patients demonstrated significant differences in skin test reactivity to the PO extracts. …

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Hardwood smoke alters murine splenic T cell responses to mitogens following a 6-month whole body inhalation exposure

Scott W. Burchiel, Fredine T. Lauer, Sandy Dunaway, Jerome A. Zawadzki et autres

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Evolution of a Human Immunodeficiency Virus Type 1 Variant with Enhanced Replication in Pig-Tailed Macaque Cells by DNA Shuffling

Katja Pekrun, Riri Shibata, Tatsuhiko Igarashi, Margaret A. Reed et autres

DNA shuffling facilitated the evolution of a human immunodeficiency virus type 1 (HIV-1) variant with enhanced replication in pig-tailed macaque peripheral blood mononuclear cells (pt mPBMC). This variant consists exclusively of HIV-1-derived sequences with the exception of simian immunodeficiency virus (SIV) nef. …

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