Paula Alejandra Baldión

Biomimetic apatite functionalization of collagen-rich membranes: Mechanical behavior, cytocompatibility, and odontoblast-like cell differentiation

Paula Alejandra Baldión, Raquel Fernández-Penas, Pedro Álvarez‐Lloret, Juan Antonio Marchal et autres

OBJECTIVES: To evaluate the effect of biomimetic apatite mineralization on the physicochemical properties, mechanical behavior, cytocompatibility, and odontogenic differentiation potential of collagen-rich membranes derived from eggshell membrane, equine tendon type I collagen, and bovine pericardium. METHODS: Membranes were mineralized for 7 days …

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HPV genotyping in head and neck cancer: Insights from a Colombian cohort

Sergio D. Cruz-Romero, Andrea Estefanía Ramos, José A. Hakim, Alberto Escallón Cubillos et autres

OBJECTIVE: To describe the frequency and distribution of Human Papillomavirus (HPV) infection in patients with Head and Neck Squamous Cell Carcinoma (HNSCC) treated at a tertiary hospital in Colombia. METHODS: A descriptive cross-sectional study was conducted in 81 patients diagnosed with HNSCC …

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Prognostic significance of MMP-14 in oral squamous cell carcinoma: insights from a Colombian cohort

Yesenia Rojas, Sergio D Cruz-Romero, Ana Margarita Baldión, José Antonio Hakim Tawil et autres

INTRODUCTION: Matrix metalloproteinase 14 (MMP-14) is crucial in extracellular matrix remodeling and tumor progression. This study evaluated MMP-14 expression in oral squamous cell carcinoma (OSCC) and its correlations with clinical, histopathological, and sociodemographic factors. METHODS: Manual tissue microarrays were constructed from 39 …

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Laser-stimulated human gingival fibroblasts: alterations in migration, secretome production, and induction of reactive oxygen species

Lina María Escobar, Marggie Grajales, Zita Bendahan, Carlos Mario Arango-Paternina et autres

This study aimed to investigate the effects of low-level laser irradiation on human gingival fibroblasts, specifically examining changes in proliferation, morphology, migration, and reactive oxygen species (ROS) production. Additionally, we assessed the impact of the secretome from irradiated fibroblasts on non-irradiated cell …

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Myricetin Modulates Matrix Metalloproteinases Expression Induced by TEGDMA in Human Odontoblast–Like Cells

Paula Alejandra Baldión, Carlos Díaz, Diego Enrique Betancourt

The activity of matrix metalloproteinases (MMPs) plays a crucial role in the aging of the resin-dentin interface. The in situ action of MMP-2 and MMP-9 has been confirmed in the process of dentin-collagen degradation. However, the involvement of dental pulp cells in …

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Biomolecule-functionalized exfoliated-graphene and graphene oxide as heteronucleants of nanocrystalline apatites to make hybrid nanocomposites with tailored mechanical, luminescent, and biological properties

Francisco Javier Acebedo-Martínez, Paula Alejandra Baldión, Francesca Oltolina, Antonia Follenzi et autres

Nanocrystalline apatite (Ap), known for its exceptional biological properties, faces limitations in hard tissue engineering due to its poor mechanical properties. To overcome this limitation, we investigated the preparation of nanocomposites through heterogeneous nucleation of calcium phosphate on exfoliated graphene (G) and …

Effect of flavonoids from grape seed and cranberry extracts on the microbiological activity of Streptococcus mutans: a systematic review of in vitro studies

Jeison Stiven Castellanos, Diego Enrique Betancourt, David Díaz‐Báez, Paula Alejandra Baldión

OBJECTIVE: To provide an overview of the available scientific evidence from in vitro studies regarding the effect induced by the flavonoids contained in grape seed extracts (GSE) and cranberry on the microbiological activity of Streptococcus mutans (S. mutans). METHODS: This systematic review …

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Osteoblastic differentiation and changes in the redox state in pulp stem cells by laser treatment

Lina María Escobar, Marggie Grajales, Zita Bendahan, Sully Jaimes et autres

The aim of this study was to determine the effect of low-level laser therapy (LLLT) on cell proliferation, mitochondrial membrane potential changes (∆Ψm), reactive oxygen species (ROS), and osteoblast differentiation of human dental pulp stem cells (hDPSCs). These cells were irradiated with …

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Apatite-coated outer layer eggshell membrane: A novel osteoinductive biohybrid composite for guided bone/tissue regeneration

Adriana Torres-Mansilla, Pedro Álvarez‐Lloret, Ana Voltes-Martínez, Elena López‐Ruiz et autres

Hybrid biomimetic materials aim to replicate the organic-inorganic constructs of mineralized tissues. During eggshell formation, the outer surface of the eggshell membrane (ESM) promotes calcium carbonate nucleation, while the inner one prevents mineralization toward the egg white and yolk. In the current …

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Hydrothermal Transformation of Eggshell Calcium Carbonate into Apatite Micro-Nanoparticles: Cytocompatibility and Osteoinductive Properties

Adriana Torres-Mansilla, Pedro Álvarez‐Lloret, Raquel Fernández-Penas, Annarita D’Urso et autres

The eggshell is a biomineral consisting of CaCO3 in the form of calcite phase and a pervading organic matrix (1–3.5 wt.%). Transforming eggshell calcite particles into calcium phosphate (apatite) micro-nanoparticles opens the door to repurposing the eggshell waste as materials with potential …

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Eggshell Membrane as a Biomaterial for Bone Regeneration

Adriana Torres-Mansilla, Maxwell T. Hincke, Ana Voltes-Martínez, Elena López‐Ruiz et autres

The physicochemical features of the avian eggshell membrane play an essential role in the process of calcium carbonate deposition during shell mineralization, giving rise to a porous mineralized tissue with remarkable mechanical properties and biological functions. The membrane could be useful by …

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Response of osteoblastic cells to low-level laser treatment: a systematic review

Juliana Garzón, Paula Alejandra Baldión, Marggie Grajales, Lina María Escobar

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