Liza Valentín-Blasini

Benzo[a]pyrene in the Mainstream Smoke of Little Cigars

Sandra I. Salido, Matthew D. Hassink, Kenneth M. Taylor, Elizabeth A. Cowan et autres

Little cigars are similar to cigarettes, with respect to dimensions, filters, and overall appearance. Some smokers also use little cigars as substitutes for cigarettes. Comparison of little cigars with cigarettes is relevant to understanding their respective public health impact. To understand their …

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Analytical methods for Ir-192 determination and their comparison

Olga N. Piraner, Karlee Eardley, Jonathan Button, Cynthia D. Ward et autres

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Investigation of select radionuclides stability in urine under various conditions for liquid scintillation counting (LSC)

Olga N. Piraner, Jonathan Button, Cynthia D. Ward, Liza Valentín-Blasini

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Tobacco-Specific Nitrosamines in Current Commercial Large Cigars, Cigarillos, and Little Cigars

Jiu Ai, Matthew D. Hassink, Kenneth M. Taylor, Peter Kuklenyik et autres

We measured levels of nitrosonornicotine (NNN) and 4-[methyl(nitroso)amino]-1-(3-pyridinyl)-1-butanone (NNK), the two most carcinogenic tobacco-specific nitrosamines, in the filler, binder, and wrapper of 50 cigars: 19 large cigars, 23 cigarillos, and 8 little cigars. The average NNN and NNK levels were 10.6 and …

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Mouth Level Intake of Nicotine from Three Brands of Little Filtered Cigars with Widely Differing Product Characteristics Among Adult Consumers

David L. Ashley, Wanzhe Zhu, Clifford H. Watson, Roberto Bravo et autres

Little filtered cigars are tobacco products with many cigarette-like characteristics. However, despite cigars falling under the U.S. Food and Drug Administration regulatory authority, characterizing flavors, which are still allowed in little filtered cigars, and filter design may influence how people use the …

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Response to ‘Comments on “Tobacco-Specific Nitrosamines in the Tobacco and Mainstream Smoke of Commercial Little Cigars”’ Letter to Editor

Selvin H. Edwards, Matthew D. Hassink, Kenneth M. Taylor, Clifford H. Watson et autres

ADVERTISEMENT RETURN TO ISSUEPREVLetters to the Edito...Letters to the EditorNEXTResponse to 'Comments on "Tobacco-Specific Nitrosamines in the Tobacco and Mainstream Smoke of Commercial Little Cigars"' Letter to EditorSelvin H. Edwards*Selvin H. EdwardsCenter for Tobacco Products, Food and Drug Administration, Beltsville, Maryland 20705, …

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Hydrogen Cyanide and Aromatic Amine Yields in the Mainstream Smoke of 60 Little Cigars

Jiu Ai, Matthew D. Hassink, Kenneth M. Taylor, Victoria Nicole Deycard et autres

Mainstream smoke yields of hydrogen cyanide (HCN) and three aromatic amines, 1-aminonaphthalene, 2-aminonaphthalene, and 4-aminobiphenyl, from 60 little cigar brands currently on the US market were measured for both International Organization for Standardization (ISO) and Canadian Intense (CI) smoking regimens. The smoke …

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Associations between microbial communities and key chemical constituents in U.S. domestic moist snuff

Robert E. Tyx, Angel J. Rivera, Glen A. Satten, Lisa Mari Keong et autres

BACKGROUND: Smokeless tobacco (ST) products are widely used throughout the world and contribute to morbidity and mortality in users through an increased risk of cancers and oral diseases. Bacterial populations in ST contribute to taste, but their presence can also create carcinogenic, …

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Early Changes in Puffing Intensity When Exclusively Using Open-Label Very Low Nicotine Content Cigarettes

Cassidy M. White, Clifford H. Watson, Roberto Bravo Cardenas, Phuong Ngac et autres

INTRODUCTION: In response to reducing cigarette nicotine content, people who smoke could attempt to compensate by using more cigarettes or by puffing on individual cigarettes with greater intensity. Such behaviors may be especially likely under conditions where normal nicotine content (NNC) cigarettes …

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The Quantitation of Squalene and Squalane in Bronchoalveolar Lavage Fluid Using Gas Chromatography Mass Spectrometry

Elizabeth A. Cowan, Hang Tran, Clifford H. Watson, Benjamin C. Blount et autres

Chemicals of unknown inhalational toxicity are present in electronic cigarette and vaping products. E-cigarettes typically contain nicotine and other relatively hydrophilic chemicals while vaping products typically contain cannabinoids and other hydrophobic chemicals. For example, vaping products can include hydrophobic terpenes such as …

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High-Performance Liquid Chromatography–Tandem Mass Spectrometry Analysis of Carbonyl Emissions from E-Cigarette, or Vaping, Products

Megan McGuigan, Gala M. Chapman, Erica Lewis, Clifford H. Watson et autres

A quantitative method was developed to measure four harmful carbonyls (acetaldehyde, acrolein, crotonaldehyde, and formaldehyde) in aerosol generated from e-cigarette, or vaping, products (EVPs). The method uses a commercially available sorbent bed treated with a derivatization solution to trap and stabilize reactive …

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Determination of Benzoic Acid and Benzyl Alcohol in E-Liquids (JUUL TM Pods) by Isotopic Dilution High-Performance Liquid Chromatography and Tandem Mass Spectrometry

Roberto Bravo Cardenas, Clifford H. Watson, Liza Valentín-Blasini

Summary The new pod devices like JUUL TM , Vuse Alto TM , myblu TM , and other “pod-mod” related products had a huge impact on the e-cigarette market, especially among teens and young adults due in particular to aggressive marketing on …

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