A novel Fc-optimized antibody-drug conjugate targeting CD7 for the therapy of T-cell acute lymphoblastic leukemia
Carina Lynn Gehlert, Denis M. Schewe, Katja Klausz, Steffen Krohn et autres
0 citationsbioRxiv (Cold Spring Harbor Laboratory)
Fotini Vogiatzi
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42Publications signalées
775Citations signalées
2Affiliations récentes
Institutions déclarées
Domaines associés
Acute Lymphoblastic Leukemia researchCAR-T cell therapy researchAcute Myeloid Leukemia ResearchChronic Lymphocytic Leukemia ResearchImmune Cell Function and Interaction
Publications récentes
Decitabine enhances antibody-dependent effects of Daratumumab immunotherapy in acute lymphoblastic leukemia models
Julia Heymann, Marie-Pauline Autenrieb, G Münch, Dorothee Winterberg et autres
0 citationsKlinische Pädiatrie
The IL-7R antagonist lusvertikimab reduces leukemic burden in xenograft ALL via antibody-dependent cellular phagocytosis
Lennart Lenk, Irène Baccelli, Anna Laqua, Julia Heymann et autres
20 citationsBlood
Enhanced potency of immunotherapy against B‐cell precursor acute lymphoblastic leukemia by combination of an Fc‐engineered CD19 antibody and CD47 blockade
Denis M. Schewe, Fotini Vogiatzi, Ira A. Münnich, Tobias Zeller et autres
6 citationsHemaSphere
A Novel Fc-Optimized Antibody Drug Conjugate Targeting CD7 As a Therapeutic Strategy in T-Cell Acute Lymphoblastic Leukemia
Carina Lynn Gehlert, Denis M. Schewe, Katja Klausz, Steffen Krohn et autres
4 citationsBlood
AP-1 Transcription Factor Complex Members FOSB and FOS are Linked With CNS Infiltration and Inferior Prognosis in Childhood T-ALL
Lea Spory, Johannes Zimmermann, Michaela Vossen‐Gajcy, Thomas Beder et autres
4 citationsHemaSphere
Abstract 2957: CD127 is expressed by acute lymphoblastic leukemias and is efficiently targeted by the IL7R-antagonist OSE-127 through macrophage-mediated antibody dependent phagocytosis
Irène Baccelli, Lennart Lenk, Anna Laqua, Dorothee Winterberg et autres
1 citationCancer Research
Molecular complete remission following combination treatment of daratumumab and venetoclax in an adolescent with relapsed mixed phenotype acute leukemia
Martin Stanulla, Denis M. Schewe, Beat Bornhäuser, Jean‐Pierre Bourquin et autres
7 citationsAnnals of Hematology
Isocitrate dehydrogenase 1 mutation drives leukemogenesis by PDGFRA activation due to insulator disruption in acute myeloid leukemia (AML)
Sophie Steinhäuser, Patrı́cia Silva, Lennart Lenk, Thomas Beder et autres
13 citationsLeukemia
The IL7R-Antagonist OSE-127 Blocks Acute Lymphoblastic Leukemia Development Via a Dual Mode of Action
Lennart Lenk, Irène Baccelli, Dorothee Winterberg, Anna Dietterle et autres
0 citationsBlood
Myeloid checkpoint blockade improves killing of T-acute lymphoblastic leukemia cells by an IgA2 variant of daratumumab
Niklas Baumann, Christian Arndt, Judith Petersen, Marta Lustig et autres
17 citationsFrontiers in Immunology
Preclinical Evidence for the Efficacy of CD79b Immunotherapy in B-cell Precursor Acute Lymphoblastic Leukemia
Lennart Lenk, Dorothee Winterberg, Fotini Vogiatzi, Anna Laqua et autres
10 citationsHemaSphere
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