Julian M. Roessler

A torpor-like state in mice slows blood epigenetic aging and prolongs healthspan

Lorna Jayne, Aurora J. Lavin-Peter, Julian M. Roessler, Alexander Tyshkovskiy et autres

Torpor and hibernation are extreme physiological adaptations of homeotherms associated with pro-longevity effects. Yet the underlying mechanisms of how torpor affects aging, and whether hypothermic and hypometabolic states can be induced to slow aging and increase healthspan, remain unknown. Here we demonstrate …

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Multi-species genome-wide CRISPR screens identify conserved suppressors of cold-induced cell death

Breanna Lam, Kathrin M Kajderowicz, Heather R. Keys, Julian M. Roessler et autres

Summary Cells must adapt to environmental changes to maintain homeostasis. One of the most striking environmental adaptations is entry into hibernation during which core body temperature can decrease from 37°C to as low at 4°C. How mammalian cells, which evolved to optimally …

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Multi-species genome-wide CRISPR screens identify conserved suppressors of cold-induced cell death

Breanna Lam, Kathrin M Kajderowicz, Heather R. Keys, Julian M. Roessler et autres

Summary Cells must adapt to environmental changes to maintain homeostasis. One of the most striking environmental adaptations is entry into hibernation during which core body temperature can decrease from 37°C to as low at 4°C. How mammalian cells, which evolved to optimally …

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Author response: Multi-species genome-wide CRISPR screens identify conserved suppressors of cold-induced cell death

Breanna Lam, Kathrin M Kajderowicz, Heather R. Keys, Julian M. Roessler et autres

Cells must adapt to environmental changes to maintain homeostasis. One of the most striking environmental adaptations is entry into hibernation during which core body temperature can decrease from 37°C to as low at 4°C. How mammalian cells, which evolved to optimally function …

us (code pays fourni par la source)

Multi-species genome-wide CRISPR screens identify conserved suppressors of cold-induced cell death

Breanna Lam, Kathrin M Kajderowicz, Heather R. Keys, Julian M. Roessler et autres

Cells must adapt to environmental changes to maintain homeostasis. One of the most striking environmental adaptations is entry into hibernation during which core body temperature can decrease from 37°C to as low at 4°C. How mammalian cells, which evolved to optimally function …

us (code pays fourni par la source)

The effect of a selenium-based anti-inflammatory strategy on postoperative functional recovery in high-risk cardiac surgery patients - A nested sub-study of the sustain CSX trial

Sascha Ott, Zheng‐Yii Lee, Lukas Martin Müller-Wirtz, Busra Cangut et autres

AIM: The cardiac surgery-related ischemia-reperfusion-related oxidative stress triggers the release of cytotoxic reactive oxygen and nitrogen species, contributing to organ failure and ultimately influencing patients' short- and long-term outcomes. Selenium is an essential co-factor for various antioxidant enzymes, thereby contributing to the …

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A torpor-like state (TLS) in mice slows blood epigenetic aging and prolongs healthspan

Lorna Jayne, Aurora J. Lavin-Peter, Julian M. Roessler, Alexander Tyshkovskiy et autres

Abstract Torpor and hibernation are extreme physiological adaptations of homeotherms associated with pro-longevity effects. Yet the underlying mechanisms of how torpor affects aging, and whether hypothermic and hypometabolic states can be induced to slow aging and increase health span, remain unknown. We …

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Video Laryngoscopy vs Direct Laryngoscopy for Endotracheal Intubation in the Operating Room

Kurt Ruetzler, Sergio Bustamante, Marc T. Schmidt, Federico Almonacid‐Cardenas et autres

Importance: Endotracheal tubes are typically inserted in the operating room using direct laryngoscopy. Video laryngoscopy has been reported to improve airway visualization; however, whether improved visualization reduces intubation attempts in surgical patients is unclear. Objective: To determine whether the number of intubation …

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Long ant life span is maintained by a unique heat shock factor

Karl M. Glastad, Julian M. Roessler, Janko Gospočić, Roberto Bonasio et autres

Eusocial insect reproductive females show strikingly longer life spans than nonreproductive female workers despite high genetic similarity. In the ant Harpegnathos saltator ( Hsal ), workers can transition to reproductive “gamergates,” acquiring a fivefold prolonged life span by mechanisms that are poorly …

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Association between body mass index and difficult intubation with a double lumen tube: A retrospective cohort study

Anand R. Mehta, Yasdet Maldonado, Mahmoud A. Abdalla, Julian M. Roessler et autres

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Long lifespan is maintained by a unique Heat Shock Factor in reproductive ants

Karl M. Glastad, Julian M. Roessler, Janko Gospočić, Shelley L. Berger

Abstract Among eusocial insects, reproductive females show longer lifespan than non-reproductive female workers despite high genetic similarity. Using an ant species ( Harpegnathos saltator, Hsal ) featuring inducible worker reproduction and correlated extended lifespan, we find that long-lived reproductive individuals (called “gamergates”) …

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Fumarate is a terminal electron acceptor in the mammalian electron transport chain

Jessica B. Spinelli, Paul C. Rosen, Hans‐Georg Sprenger, Anna M. Puszynska et autres

For electrons to continuously enter and flow through the mitochondrial electron transport chain (ETC), they must ultimately land on a terminal electron acceptor (TEA), which is known to be oxygen in mammals. Paradoxically, we find that complex I and dihydroorotate dehydrogenase (DHODH) …

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