Enzo Palese

Nerve growth factor receptor p75NTR interacts with Toll-like receptor 4 and the alarmins high mobility group box 1 and nucleophosmin: a novel inflammatory mechanism in psoriasis

Sara Sileno, M D'agostino, Luciapia Farina, Andrea Kosta et autres

BACKGROUND: Nerve growth factor (NGF) is upregulated in psoriatic skin, and increasing evidence indicates that its receptor, p75 neurotrophin receptor (p75NTR), promotes inflammatory responses. However, the contribution of p75NTR and its ligand, pro-nerve growth factor (proNGF), in psoriasis inflammation remains unclear. OBJECTIVES: …

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Genetic Markers of Tumor Multiplicity in Non-melanoma Skin Cancer: Associations of 19 SNPs in an Italian Cohort

Irene Campana, Ylenia Aura Minafò, Giovanni Luca Scaglione, Giulia Giovanardi et autres

Ultraviolet exposure is the main environmental risk factor for non-melanoma skin cancers (NMSCs), but genetic susceptibility also contributes to variability in disease burden among individuals. This study analyzed selected single-nucleotide polymorphisms (SNPs) in genes related to vitamin D and nicotinamide adenine dinucleotide …

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Syphilis, the great mimicker: an inverted diagnostic pathway that still hits the mark

Barbara Cocuroccia, Francesca Passarelli, Enzo Palese, Alessandra Latini et autres

Dear Editor, Syphilis, the "great mimicker", remains a diagnostic challenge despite reliable serologic assays and updated management guidelines. Its wide variety of clinical and dermatological manifestations often leads to misdiagnosis, especially when lesions are atypical. We present a case in which secondary …

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Localized dominant dystrophic epidermolysis bullosa worsened by diabetes

Alessia Primerano, Giovanna Floriddia, Emanuela De Domenico, Maria Chiara Collina et autres

Dystrophic epidermolysis bullosa (DEB) is a clinically heterogeneous blistering disease caused by pathogenic variants in the COL7A1 gene. Phenotypes range from localized to generalized and are primarily determined by the variant type, though additional modifiers influence disease severity. To characterize the molecular …

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Juvenile gangrenous vasculitis of the scrotum: a rare entity and a diagnostic challenge

Barbara Cocuroccia, Giorgio Annessi, Enzo Palese, Siavash Rahimi et autres

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A spindle cell neoplasm with MYH9::EGFR fusion and co‐expression of S100 and CD34 , further expanding the family of kinase fusion positive spindle cell neoplasms

Elisabetta Caprini, Sofia Verkhovskaia, Beatrice Casini, Adele Testi et autres

Soft tissue neoplasms displaying CD34 and S100 positivity with immunohistochemistry are rare with a wide morphological range and frequent neurotrophic tyrosine receptor kinase (NTRK) alterations. Recent reports describe fusions in other kinases besides NTRK in these tumors. In the present article, we …

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Basal cell carcinoma thickness evaluated by high-frequency ultrasounds and correlation with dermoscopic features

Rosa Coppola, Mauro Barone, Salvatore Zanframundo, Valeria Devirgiliis et autres

BACKGROUND: Basal cell carcinoma (BCC) is the most common skin cancer, and it can be easily treated by surgery or by various other physical modalities and topical chemotherapy. For metastatic, locally advanced BCC and for cancers that cannot be removed by surgery, …

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Basal cell carcinoma thickness evaluated by high-frequency ultrasounds and correlation with dermoscopic features.

Rosa Coppola, Mauro Barone, Salvatore Zanframundo, Valeria Devirgiliis et autres

BACKGROUND: Basal cell carcinoma (BCC) is the most common skin cancer, and it can be easily treated by surgery or by various other physical modalities and topical chemotherapy. For metastatic, locally advanced BCC and for cancers that cannot be removed by surgery, …

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Systemic Photoprotection in Skin Cancer Prevention: Knowledge among Dermatologists

Luca Fania, Francesca Sampogna, Francesco Ricci, Mariafrancesca Hyeraci et autres

Background: Systemic photoprotection (i.e., administration of substances such as nicotinamide, carotenoids, and vitamin D) may be important to reduce photocarcinogenesis or to support long-term protection against UV irradiation. Clinical trials showed that oral nicotinamide is effective in reducing the onset of new …

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Scarce knowledge of systemic photoprotection among skin cancer patients: a cross-sectional survey.

Luca Fania, Francesco Ricci, Andrea Paradisi, Enzo Palese et autres

BACKGROUND: The incidence of both melanoma and non-melanoma skin cancers (NMSC) is increasing worldwide and these tumours have become an important health issue. Topical and systemic photoprotection are the cornerstone to decrease the incidence of these tumours. OBJECTIVES: The aim of this …

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Reticulated erythema of the breast: a case of intravascular histiocytosis with hemophagocytosis

Enzo Palese, Vincenzo Panasiti, Rosa Coppola, Maurizio Nudo et autres

article: Reticulated erythema of the breast: a case of intravascular histiocytosis with hemophagocytosis - Giornale Italiano di Dermatologia e Venereologia 2020 December;155(6):796-8 - Minerva Medica - Journals

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Investigating Serum and Tissue Expression Identified a Cytokine/Chemokine Signature as a Highly Effective Melanoma Marker

Marco Cesati, Francesca Scatozza, Daniela D’Arcangelo, Gian Carlo Antonini-Cappellini et autres

The identification of reliable and quantitative melanoma biomarkers may help an early diagnosis and may directly affect melanoma mortality and morbidity. The aim of the present study was to identify effective biomarkers by investigating the expression of 27 cytokines/chemokines in melanoma compared …

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