Accès ouvert
2025
article
OpenAlex
Alessandra Trojani, Ester Pungolino, Barbara Di Camillo, Luca Emanuele Bossi et autres
BACKGROUND: fusion gene, which encodes a tyrosine kinase protein that drives the uncontrolled proliferation and survival of leukemic stem cells (LSCs). Nilotinib, a tyrosine kinase inhibitor, targets the activity of BCR-ABL1 by reducing aberrant signaling pathways, which drive the regeneration of LSCs. …
it
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Accès ouvert
2024
article
OpenAlex
Alessandra Trojani, Alessandro Beghini, Luca Emanuele Bossi, Marta Rachele Stefanucci et autres
BACKGROUND: Despite recurrent and activating mutations, including MYD88, CXCR4, ARID1A, KMT2D, and CD79B were identified, the genetic basis for Waldenström's Macroglobulinemia (WM) and the risk of progression of IgM MGUS to WM remain to be fully elucidated. METHODS: We investigated the mutation …
it
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Accès ouvert
2024
article
OpenAlex
Alessandra Trojani, Luca Emanuele Bossi, Roberto Cairoli
Background: This review aims to provide an overview of the potential impact of fasting and diet on cancer, and in particular, on chronic lymphocytic leukemia (CLL), which is the most frequent form of leukemia in the Western world. Methods: Experimental and clinical …
it
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Accès ouvert
2023
conference-abstract
OpenAlex
Luca Emanuele Bossi, Cassandra Palumbo, Alessandra Trojani, Agostina Melluso et autres
Introduction This study aimed to investigate the underlying reasons behind sustained significant continuous deep fluctuations in the absolute lymphocyte count (ALC) in an untreated patient with Chronic Lymphocytic Leukemia (CLL), who has maintained a favorable prognosis since the time of diagnosis in …
it
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Accès ouvert
2023
conference-abstract
OpenAlex
Alessandra Trojani, Alessandro Beghini, Luca Emanuele Bossi, Marta Rachele Stefanucci et autres
Background Waldenström's Macroglobulinemia (WM) is an incurable B-cell neoplasm characterized by serum monoclonal immunoglobulin M (IgM) and clonal lymphoplasmacytic cells infiltrating the bone marrow (BM). Smoldering WM (sWM) is the asymptomatic/indolent form with a high risk of progressing to symptomatic WM requiring …
it
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Accès ouvert
2023
article
OpenAlex
Nazanin Abazari, Marta Rachele Stefanucci, Luca Emanuele Bossi, Alessandra Trojani et autres
Wnt/β-catenin signaling is critically required for the development and maintenance of leukemia stem cells (LSCs) in acute myeloid leukemia (AML) by constitutive activation of myeloid regeneration-related pathways. Cell-intrinsic activation of canonical Wnt signaling propagates in the nucleus by β-catenin translocation, where it …
it
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Accès ouvert
2023
article
OpenAlex
Luca Emanuele Bossi, Cassandra Palumbo, Alessandra Trojani, Agostina Melluso et autres
Background and Objectives: This study aimed to investigate the causes of continuous deep fluctuations in the absolute lymphocyte count (ALC) in an untreated patient with Chronic Lymphocytic Leukemia (CLL), who has had a favorable prognosis since the time of diagnosis. Up until …
it
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Accès ouvert
2022
article
OpenAlex
Luca Emanuele Bossi
Efficient Strategies for the Reuse of Surgical and FFP2
it, us
(code pays fourni par la source)
2022
article
OpenAlex
Alessandro Beghini, Livia Leuzzi, Nazanin Abazari, Luca Emanuele Bossi et autres
Abstract The ever‐increasing advances in high‐throughput sequencing have broadened our understanding of the genetic pathogenesis of Philadelphia‐negative myeloproliferative neoplasms (MPNs). Convergent studies have shown that MPN driver mutations associate with additional mutations found in genes coding for negative regulators of the JAK/STAT …
it
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2021
conference-abstract
OpenAlex
Alessandra Trojani, Barbara Di Camillo, Luca Emanuele Bossi, Antonino Greco et autres
Abstract We performed a comparative gene expression profiling (GEP) study on B-cells and plasma cells of Waldenström Macroglobulinemia (WM), IgM monoclonal gammopathies of undetermined significance (IgMMGUS), and normal individuals (CTRLs) to identify GEP changes as reliable predictors of progression of IgMMGUS to …
it
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Accès ouvert
2021
article
OpenAlex
Alessandra Trojani, Barbara Di Camillo, Luca Emanuele Bossi, Livia Leuzzi et autres
Waldenström Macroglobulinemia (WM) is a B-cell lymphoma characterized by the precursor condition IgM monoclonal gammopathies of undetermined significance (IgM MGUS). We performed a gene expression profiling study to compare the transcriptome signatures of bone marrow (BM) B-cells and plasma cells of 36 …
it
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2020
conference-abstract
OpenAlex
Alessandra Trojani, Barbara Di Camillo, Luca Emanuele Bossi, Alessandra Tedeschi et autres
We performed gene expression profiling (GEP) of 36 patients with Waldenström's Macroglobulinemia (WM), 13 subjects with Monoclonal Gammopathy of Uncertain Significance (IgMMGUS), and 7 healthy subjects (CTRLs) by Affymetrix GeneChip Human Genome U133 Plus 2.0. GEP was performed on 36 WM bone …
it
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