Vihitaben S. Patel

Low intensity mechanical signals promote proliferation in a cell-specific manner: Tailoring a non-drug strategy to enhance biomanufacturing yields

M. Ete Chan, Christopher Ashdown, Lia Strait, Sishir Pasumarthy et autres

proliferation in CHO-suspension cells (-13%). Another set of LIV parameters (30 Hz, 0.7 g, 2 × 60 min/d, 2 hr refractory period) however, were able to increase the proliferation of CHO-suspension cells by 210% and T-cells by 20.3%. Importantly, we also reported …

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Low intensity mechanical signals promote proliferation in a cell-specific manner: Tailoring a non-drug strategy to enhance biomanufacturing yields

M. Ete Chan, Lia Strait, Christopher Ashdown, Sishir Pasumarthy et autres

Abstract Biomanufacturing relies on living cells to produce biotechnology-based therapeutics, tissue engineering constructs, vaccines, and a vast range of agricultural and industrial products. With the escalating demand for these bio-based products, any process that could improve yields and shorten outcome timelines by …

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List of Contributors

David Abraham, Maria Cecília Puntel de Almeida, Elena Ambrogini, Andrew Arnold et autres

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Mechanisms of exercise effects on bone quantity and quality

Vihitaben S. Patel, Stefan Judex, Janet Rubin, Clinton T. Rubin

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Combating osteoporosis and obesity with exercise: leveraging cell mechanosensitivity

Gabriel M. Pagnotti, Maya Styner, Gunes Uzer, Vihitaben S. Patel et autres

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Marrow Adiposity and Hematopoiesis in Aging and Obesity: Exercise as an Intervention

Vihitaben S. Patel, M. Ete Chan, Janet Rubin, Clinton T. Rubin

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The Role of Low Intensity Vibrations in Adipocyte Inflammatory Response

Brayan Vazquez, Guniz Bas Uzer, Vihitaben S. Patel, Ete Chan et autres

Adipocytes found in bone marrow and adipose tissues functions an energy depot for excess energy. Excessive lipid storage in adipocytes in cases like obesity leads to secretion of pro-inflammatory cytokines, causing chronic inflammation associated with type II diabetes and other metabolic disorders. …

Mechanical signals protect stem cell lineage selection, preserving the bone and muscle phenotypes in obesity

Danielle M. Frechette, Divya Krishnamoorthy, Tee Pamon, M. Ete Chan et autres

The incidence of obesity is rapidly rising, increasing morbidity and mortality rates worldwide. Associated comorbidities include type 2 diabetes, heart disease, fatty liver disease, and cancer. The impact of excess fat on musculoskeletal health is still unclear, although it is associated with …

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Incorporating Refractory Period in Mechanical Stimulation Mitigates Obesity‐Induced Adipose Tissue Dysfunction in Adult Mice

Vihitaben S. Patel, M. Ete Chan, Gabriel M. Pagnotti, Danielle M. Frechette et autres

OBJECTIVE: The aim of this study was to determine whether inclusion of a refractory period between bouts of low-magnitude mechanical stimulation (LMMS) can curb obesity-induced adipose tissue dysfunction and sequelae in adult mice. METHODS: A diet-induced obesity model that included a diet …

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