Bo Chen

On the Robustness of Preoperative Intranasal Dexmedetomidine for Postoperative Delirium Prevention: Methodological Considerations [Letter]

Hongyu Gai, Minggan Bao, Bo Chen

We read with great interest the randomized trial by Liu et al 1 investigating preoperative intranasal dexmedetomidine for postoperative delirium (POD) prevention in older adults undergoing joint arthroplasty.The authors should be commended for addressing a clinically important question in a vulnerable population.However, …

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1,25-Dihydroxyvitamin D3 mitigates high glucose-induced oxidative stress, inflammation, and extracellular matrix accumulation in glomerular mesangial cells via the ROS/TXNIP/NLRP3 pathway.

Qingyue Meng, Bo Chen, Chunjiang Zhang, Lin Jia et autres

BACKGROUND: in diabetic nephropathy (DN) progression and its underlying mechanism targeting the ROS/TXNIP/NLRP3 inflammasome pathway. METHODS: (1-50 nM), or high glucose plus N-acetylcysteine (NAC, 10 mM). Cell viability was assessed by the CCK-8 assay. Oxidative stress parameters (ROS via DCFH-DA fluorescence, MDA …

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Synthesis, structure, magnetic property, and proton conduction of a hydrogen-bonded framework assembled from Fe(II) coordination chains

Feng‐Li Chen, Jiong Yang, Bo Chen, Dong Shao

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Correction: SNORA47 affects stemness and chemotherapy sensitivity via EBF3/RPL11/c-Myc axis in luminal A breast cancer

Ying Zhou, Zixian Dong, Weitao Wang, Menghan Wang et autres

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SNORA47 affects stemness and chemotherapy sensitivity via EBF3/RPL11/c-Myc axis in luminal A breast cancer

Ying Zhou, Zixian Dong, Weitao Wang, Menghan Wang et autres

Chemotherapy sensitivity is an important factor that restricts the prognosis of breast cancer, and breast cancer stem cells (BCSCs) are the root cause of chemotherapy sensitivity. SNORA47, a member of the small nucleolar RNAs, has not been documented in the context of …

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Expanding the enzymatic toolbox for β-amino acids and unnatural amino acids manufacturing

Feng Zhang, Q. Sheikh, Bo Chen, Kang Lan Tee et autres

β-Amino acids, characterized by the separation of their terminal carboxylic acid and amino groups by two carbon atoms (Cα and Cβ), exhibit remarkable structural versatility. This arrangement allows for R or S isomers at both Cα and Cβ positions, resulting in up …

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NanoAbLLaMA: construction of nanobody libraries with protein large language models

Xin Wang, Haotian Chen, Bo Chen, Lixin Liang et autres

Introduction: Traditional methods for constructing synthetic nanobody libraries are labor-intensive and time-consuming. This study introduces a novel approach leveraging protein large language models (LLMs) to generate germline-specific nanobody sequences, enabling efficient library construction through statistical analysis. Methods: We developed NanoAbLLaMA, a protein …

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Clinical characteristics and prognostic implications in patients with HER2-low breast cancer undergoing neoadjuvant chemotherapy: a retrospective cohort study

Ang Zheng, Junlin He, Muyao Li, Yao Fan et autres

Background: HER2-low breast cancer represents a distinct biological subtype, and its clinical characteristics and prognostic outcomes require further exploration. This study aimed to investigate disparities in short- and long-term outcomes between HER2-0 and HER2-low breast cancer patients undergoing neoadjuvant chemotherapy (NAC) in …

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THE CLINICAL VALUE OF USING FROZEN DRIED FIBRIN GLUE INJECTION THERAPY FOR PSEUDOANEURYSM UNDER ULTRASOUND-GUIDED

Yanli Hu, Bo Chen, Suzhen Ran

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Permeability and Compressive Strength of Pervious Cement Concrete with Small Size Aggregates

Bo Chen, Feng Zhang, Lin Lv, Yin Bai et autres

Abstract To prepare high-performance pervious concrete with excellent mechanical properties and permeability, an orthogonal test method is used to investigate the effects of water-to-binder (W/B) ratio, grading of small size aggregates, and target continuous void content on the mechanical properties and permeability …

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Salivary gland protective and antiinflammatory effects of genistein in Sjögren’s syndrome by inhibiting Xist/ACSL4-mediated ferroptosis following binding to estrogen receptor-alpha

Tianjiao Mao, Wei Wei, Bo Chen, Yixin Chen et autres

Abstract Background Sjögren’s syndrome (SS) is an autoimmune disease with limited effective treatment options. This study aimed to explore the underlying mechanism by which genistein–estrogen receptor alpha (ERα) complex targets X-inactive specific transcript (Xist) then leads to the inhibition of ferroptosis by …

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Corrigendum: Combination of rapamycin and MK-2206 induced cell death via autophagy and necroptosis in MYCN-amplified neuroblastoma cell lines

Yudi Dong, Wei Gong, Zhongyan Hua, Bo Chen et autres

Error in FigureIn the published article, there was an error in Figure 3B as published. The Western Blot strip of RIPK1 in NGP cells were duplicated to the RIPK1 strip in BE2 cells in Figure 3B. In the original submission of the …

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