Preclinical safety and biodistribution of SPVN06, a novel gene- and mutation-independent gene therapy for rod-cone dystrophies
Mélanie Marie, Lucie Churet, Anne-Sophie Gautron, Rafal Farjo et autres
6 citationsGene Therapy
Florence Lorget
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32Publications signalées
1430Citations signalées
0Affiliations récentes
Domaines associés
Bone Metabolism and DiseasesRetinal Development and DisordersBone health and treatmentsRetinal Diseases and TreatmentsInfant Nutrition and Health
Publications récentes
A 3-month gene therapy single-dose IV administration pharmacology and safety study with ST-920 (isaralgagene civaparvovec) for Fabry disease in mice
Kathleen Meyer, Florence Lorget, Gregg Prawdzik, Marina Falaleeva et autres
1 citationMolecular Genetics and Metabolism
A 1-Month Toxicology and Biodistribution NHP Pilot Study Evaluating a Single Subretinal Bilateral Administration of SPVN06 - A Novel AAV-Based Gene Therapy for the Treatment of Rod-Cone Dystrophies Agnostic of the Causative Mutation
Mélanie Marie, Myriam Marussig, Pierre-Axel Vinot, Thomas S. Vihtelic et autres
1 citationInvestigative Ophthalmology & Visual Science
SPVN06, a Novel Mutation-Independent AAV-based Gene Therapy, Protects Cone Degeneration in a Pig Model of Retinitis Pigmentosa
Jennifer Noel, Archana Jalligampala, Myriam Marussig, Pierre-Axel Vinot et autres
5 citationsInvestigative Ophthalmology & Visual Science
Tolerability Assessment of Formulation pH in New Zealand White Rabbits Following Intravitreal Administration
Nardos G. Tassew, Steven T. Laing, Jeffrey Aaronson, Isabella de Jong et autres
7 citationsToxicologic Pathology
The safety evaluation of long-acting ocular delivery systems
Evan A. Thackaberry, Florence Lorget, Cindy Farman, Vladimir Bantseev
31 citationsDrug Discovery Today
In vivo Effects of CCFD9260S Following Intravitreal Administration to Cynomolgus Monkeys
Helen Booler, Nardos G. Tassew, Aija MacKenzie, Hong Liu et autres
1 citationInvestigative Ophthalmology & Visual Science
The Presence of Protein in Formulation Ameliorates Retinal Changes Observed on OCT Following Intravitreal Administration of Hyperosmotic Solution in Cynomolgus Monkeys
Nardos G. Tassew, Vladimir Bantseev, Aija McKenzie, Roxanne Andaya et autres
0 citationsInvestigative Ophthalmology & Visual Science
Retinal toxicity in rabbits administered intravitreal TSG-6-rabbit FAb fusion proteins
Steven T. Laing, Devin B. Tesar, Susan Crowell, Julia Gray et autres
1 citationInvestigative Ophthalmology & Visual Science
Ocular and Systemic Pharmacokinetics of a PEGylated-anti-Factor D Fab Multimer in Cynomolgous Monkeys
Daniela Bumbaca Yadav, Whitney Shatz-Binder, Danielle Mandikian, C. Andrew Boswell et autres
0 citationsInvestigative Ophthalmology & Visual Science
Intravitreal Administrations of pH 4.0-5.5 Vehicle Solutions are Well Tolerated in NZW rabbits
Florence Lorget, Steven T. Laing, Chris Schuetz, Isabella de Jong et autres
0 citationsInvestigative Ophthalmology & Visual Science
Evaluation of the Toxicity of Intravitreally Injected PLGA Microspheres and Rods in Monkeys and Rabbits: Effects of Depot Size on Inflammatory Response
Evan A. Thackaberry, Cindy Farman, Fiona Zhong, Florence Lorget et autres
81 citationsInvestigative Ophthalmology & Visual Science
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