Federico Remes Lenicov

Influence of the Cholinergic System on the Pathogenesis of Glioblastoma: Impact of the Neutrophil Granulocytes

Alejandra Infante Cruz, Paula María Saibene Vélez, Cynthia Arasanz, Micaela Rosato et autres

Glioblastoma (GBM) is the most common malignant primary brain tumor in adults. Since numerous studies highlight the significance of cholinergic system components in tumor development, acetylcholine (ACh) and the differential activation of its receptors could play a crucial role in GBM progression. …

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Advancing multiplex diagnostics: A novel framework for simultaneous detection of diverse pathogens using respiratory RNA viruses as a model system

Mariela Caputo, Santiago Ginart, Laia Garrigós, Daniel Corach et autres

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Correction: Relevance of Thymic Stromal Lymphopoietin on the Pathogenesis of Glioblastoma: Role of the Neutrophil

Alejandra Infante Cruz, Juan Valentin Coronel, Paula Saibene Vélez, Federico Remes Lenicov et autres

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Relevance of Thymic Stromal Lymphopoietin on the Pathogenesis of Glioblastoma: Role of the Neutrophil

Alejandra Infante Cruz, Juan Valentin Coronel, Paula Saibene Vélez, Federico Remes Lenicov et autres

Abstract Glioblastoma multiforme (GBM) is the most predominant and malignant primary brain tumor in adults. Thymic stromal lymphopoietin (TSLP), a cytokine primarily generated by activated epithelial cells, has recently garnered attention in cancer research. This study was aimed to elucidate the significance …

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Ethical issues in the use of leftover samples and associated personal data obtained from diagnostic laboratories

Federico Remes Lenicov, Nilda E. Fink

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Extracellular vesicles from human plasma dampen inflammation and promote tissue repair functions in macrophages

Alan M. Adamczyk, María Luz Leicaj, Martina P. Fabiano, Gonzalo Cabrerizo et autres

Although inflammation is a vital defence response to infection, if left uncontrolled, it can lead to pathology. Macrophages are critical players both in driving the inflammatory response and in the subsequent events required for restoring tissue homeostasis. Extracellular vesicles (EVs) are membrane-enclosed …

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Viable SARS-CoV-2 Omicron sub-variants isolated from autopsy tissues

Santiago Maffia‐Bizzozero, Cintia Cevallos, Federico Remes Lenicov, Rosa Nicole Freiberger et autres

Introduction Pulmonary and extrapulmonary manifestations have been described after infection with SARS-CoV-2, the causative agent of coronavirus disease 2019 (COVID-19). The virus is known to persist in multiple organs due to its tropism for several tissues. However, previous reports were unable to …

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Overview of the SARS-CoV-2 genotypes circulating in Latin America during 2021

José Arturo Molina-Mora, Jhonnatan Reales-González, Erwin Camacho, Francisco Duarte-Martínez et autres

Latin America is one of the regions in which the COVID-19 pandemic has a stronger impact, with more than 72 million reported infections and 1.6 million deaths until June 2022. Since this region is ecologically diverse and is affected by enormous social …

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Resistance to Prostaglandin E2 Promotes Monocyte Activation During Chronic HIV Infection

Facundo Di Diego García, Gonzalo Cabrerizo, Ana Paletta, Paula S. Pérez et autres

BACKGROUND: Monocyte activation is a driver of inflammation in the course of chronic HIV infection. Prostaglandin E2 (PGE2) is known to mediate anti-inflammatory effects, notably the inhibition of tumor necrosis factor- (TNF-) production by monocytes. We aim to investigate the effects of …

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Overview of the SARS-CoV-2 genotypes circulating in Latin America during 2021

José Arturo Molina-Mora, Jhonnatan Reales-González, Erwin Camacho, Francisco Duarte-Martínez et autres

Abstract Latin America is one of the regions in which the COVID-19 pandemic has had a stronger impact, with more than 72 million reported infections and 1.6 million deaths until June 2022. Since this region is ecologically diverse and is affected by …

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Reply to Kao and Liaw

Valeria Ochoa, Fernando Erra Díaz, Ezequiel Ramírez, María Clara Fentini et autres

To the Editor—The letter from Kao and Liaw raises some interesting questions, none of which question the results and conclusions of our study. First, they recommend the use of fecal specimens to avoid, in their words, an uncertainty in the accuracy of …

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Platelets modulate CD4+ T‐cell function in COVID‐19 through a PD‐L1 dependent mechanism

Ana Paletta, Facundo Di Diego García, Augusto Varese, Fernando Erra Díaz et autres

Summary Severe COVID‐19 is associated with a systemic inflammatory response and progressive CD4+ T‐cell lymphopenia and dysfunction. We evaluated whether platelets might contribute to CD4+ T‐cell dysfunction in COVID‐19. We observed a high frequency of CD4+ T cell–platelet aggregates in COVID‐19 inpatients …

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