Giuliana Catara

The PARG frontier: mechanisms of PAR turnover and opportunities in precision oncology

Giuliana Catara, Gaetano Gerace, R. Lauro, Luca Palazzo

ADP-ribosylation is a versatile post-translational modification that governs fundamental processes, including DNA repair, transcription, and stress adaptation. Its homeostasis relies on the dynamic interplay between poly(ADP-ribose) polymerases (PARPs), which assemble mono- or poly-ADP-ribose (PAR) chains on target macromolecules, and ADP-ribosyl hydrolases, which …

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Sensing and Degradation of Organophosphorus Compounds by Exploitation of Heat-Loving Enzymes

Giuseppe Manco, Eros Antonio Lampitella, Nagendra Sai Kumar Achanta, Giuliana Catara et autres

The increasing incidence of organophosphate (OP) pesticide poisoning and the use of OP chemical warfare agents (CWA) in conflicts and terrorist acts need sustainable methods for sensing, decontamination, and detoxification of OP compounds. Enzymes can serve as specific, cost-effective biosensors for OPs. …

Suppression of ADP-ribosylation reversal triggers cell vulnerability to alkylating agents

Rocco Caggiano, Evgeniia Prokhorova, Lena Duma, Kira Schützenhofer et autres

• ARH3 deficiency results in increased sensitivity to PARGi in ovarian cancer cells. • ARH3 deficiency results in resistance to PARPi in ovarian cancer cells. • ARH3 and PARG loss induces alkylating agent sensitivity. • Combining ARH3 and PARG inhibition with TMZ …

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Identification and characterization of a new potent inhibitor targeting CtBP1/BARS in melanoma cells

Angela Filograna, Stefano De Tito, Matteo Lo Monte, Rosario Oliva et autres

BACKGROUND: The C-terminal-binding protein 1/brefeldin A ADP-ribosylation substrate (CtBP1/BARS) acts both as an oncogenic transcriptional co-repressor and as a fission inducing protein required for membrane trafficking and Golgi complex partitioning during mitosis, hence for mitotic entry. CtBP1/BARS overexpression, in multiple cancers, has …

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Targeting the Ubiquitin–Proteasome System and Recent Advances in Cancer Therapy

Daniela Spano, Giuliana Catara

Ubiquitination is a reversible post-translational modification based on the chemical addition of ubiquitin to proteins with regulatory effects on various signaling pathways. Ubiquitination can alter the molecular functions of tagged substrates with respect to protein turnover, biological activity, subcellular localization or protein-protein …

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Identification and characterization of a new potent inhibitor targeting CtBP1/BARS in melanoma cells

Angela Filograna, Stefano De Tito, Matteo Lo Monte, Rosario Oliva et autres

Abstract Background. The C-terminal-binding protein 1/brefeldin A ADP-ribosylation substrate (CtBP1/BARS) acts both as an oncogenic transcriptional co-repressor and as a fission inducing protein required for membrane trafficking and Golgi complex partitioning during mitosis, hence for mitotic entry. CtBP1/BARS overexpression, in multiple cancers, …

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The DarT/DarG Toxin–Antitoxin ADP-Ribosylation System as a Novel Target for a Rational Design of Innovative Antimicrobial Strategies

Giuliana Catara, Rocco Caggiano, Luca Palazzo

The chemical modification of cellular macromolecules by the transfer of ADP-ribose unit(s), known as ADP-ribosylation, is an ancient homeostatic and stress response control system. Highly conserved across the evolution, ADP-ribosyltransferases and ADP-ribosylhydrolases control ADP-ribosylation signalling and cellular responses. In addition to proteins, …

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Exploiting Drug-Discovery Research for Educational Purposes

Giuliana Catara, Cristina Rigutto

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ADP-Ribosylation Post-Translational Modification: An Overview with a Focus on RNA Biology and New Pharmacological Perspectives

Giuseppe Manco, Giuseppina Lacerra, Elena Porzio, Giuliana Catara

Cellular functions are regulated through the gene expression program by the transcription of new messenger RNAs (mRNAs), alternative RNA splicing, and protein synthesis. To this end, the post-translational modifications (PTMs) of proteins add another layer of complexity, creating a continuously fine-tuned regulatory …

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Corrigendum: Combinatorial Strategies to Target Molecularand Signaling Pathways to Disarm Cancer Stem Cells

Giuliana Catara, Antonino Colanzi, Daniela Spano

[This corrects the article DOI: 10.3389/fonc.2021.689131.].

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Combinatorial Strategies to Target Molecular and Signaling Pathways to Disarm Cancer Stem Cells

Giuliana Catara, Antonino Colanzi, Daniela Spano

Cancer is an urgent public health issue with a very huge number of cases all over the world expected to increase by 2040. Despite improved diagnosis and therapeutic protocols, it remains the main leading cause of death in the world. Cancer stem …

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WTAP and BIRC3 are involved in the posttranscriptional mechanisms that impact on the expression and activity of the human lactonase PON2

Teresa Maria Carusone, Giovanna Cardiero, Mariangela Cerreta, Luigi Mandrich et autres

The activity of human paraoxonase 2 (PON2) is rapidly reduced in cells incubated with the bacterial quorormone 3-Oxo-dodecanoyl Homoserine Lactone (3OC12HSL), an observation that led to hypothesize a fast PON2 post-translational modification (PTM). Recently, we detected a 3OC12HSL-induced PTM in a cell-free …

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