Nidhya Navanandan

General emergency department management of pediatric asthma exacerbations: the impact of pediatric readiness on guideline-concordant care

Savannah Brackman, Halden Scott, Kathleen Adelgais, Mairead Dillon et autres

OBJECTIVE: To assess guideline-concordant management of children with moderate to severe asthma exacerbations in general emergency departments (EDs) and whether pediatric readiness is associated with receipt of guideline-concordant care. METHODS: Retrospective cohort study of children 4-18 years treated at a general ED …

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Oscillometry Measures the Response to Acute Asthma Therapy in the Pediatric Emergency Department

Nidhya Navanandan, Ella Hagopian, John T. Brinton, Melisa S. Tanverdi et autres

Abstract Rationale Oscillometry is a feasible and safe method to measure pulmonary function in children with asthma exacerbations in the emergency department (ED), but its utility to measure respiratory impedance as an objective marker of response to initial acute asthma treatments is …

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Management of asthma exacerbations in pediatric emergency departments across the United States

Melisa S. Tanverdi, Isabella Zaniletti, Nidhya Navanandan, Isabel J. Hardee et autres

OBJECTIVES: There are 750,000 emergency department (ED) visits by children for asthma exacerbations in the United States annually. Despite changing evidence and epidemiology, there have not been recent assessments of acute asthma prevalence, management, and outcomes from pediatric EDs. This 40-center retrospective …

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Oscillometry and Parent-Reported Respiratory Symptom Control in Toddlers With Recurrent Wheeze: The WINDOWS Study

Katharine L. Hamlington, Nidhya Navanandan, Max A. Seibold, Angela Hui-Chia Liu

Abstract RATIONALE: Toddler-aged children with recurrent wheezing exacerbations are at risk of developing persistent asthma in childhood, but objective evaluation of lung function to guide treatment decisions remains a challenge. This study used oscillometry to characterize lung function and bronchodilator response in …

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Feasibility of Electronic Medication Monitoring for Measuring Rescue Inhaler Use After Pediatric Emergency Department Treatment for Acute Asthma Exacerbations

M. Tanverdi, J. Brinton, Nidhya Navanandan, Heather Hoch De Keyser et autres

Abstract Rationale: Rescue inhaler use after pediatric emergency department (ED) treatment for acute asthma exacerbations is poorly quantified and relies on caregiver report, which is subject to error and bias. Electronic medication monitoring (EMM) provides unbiased inhaler actuation data, though it has …

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Home Environment Risk Factors in Toddlers With Recurrent Wheeze: The Windows Study

Evan C. Johnson, Anousheh Awais Paracha, Angela Hui-Chia Liu, Muhammad Uzair Awan et autres

Abstract Rationale: Environmental exposures may play an important role in recurrent wheeze progression to persistent asthma in the early-childhood period. WINDOWS is a longitudinal cohort study of toddlers with a history of ≥3 wheezing episodes aimed at differentiating molecular, clinical, and environmental …

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Measuring Oscillometry During Recovery After Emergency Department Treatment for Asthma Exacerbations in Children

M. Tanverdi, Juana Cerna Sanchez, Susan L. MacLean, Nidhya Navanandan et autres

Abstract Rationale: Recovery after pediatric emergency department (ED) treatment for acute asthma exacerbations is poorly understood. Oscillometry is a safe and effort-independent method to measure respiratory system resistance and compliance in both the ED and outpatient follow-up settings to objectively evaluate lung …

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Oscillometry Measures the Response to Acute Asthma Therapy in the Pediatric Emergency Department

Nidhya Navanandan, Ellen J. Hagopian, J. Brinton, M. Tanverdi et autres

Abstract Rationale: Oscillometry is a feasible and safe method to measure lung function in children with asthma exacerbations in the emergency department (ED), but its utility to measure respiratory impedance as an objective marker of ED therapeutic response is unknown. We aimed …

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Unique Airway Immune Responses and Epithelial Pathobiology Underlie Viral Wheezing Illnesses in Young Children

Jamie L. Everman, Elizabeth A. Secor, Katharine L. Hamlington, Kerrilyn R. Diener et autres

Abstract RATIONALE: Viral infections are common in early childhood, with most children either being asymptomatic or having only upper respiratory symptoms. However, some children develop lower respiratory symptoms, including wheezing, which can result in hospitalization. A subset of these children have repeated …

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Viral Determinants of Childhood Asthma Exacerbation Severity and Treatment Response

Nidhya Navanandan, Nathan D. Jackson, Katharine L. Hamlington, Jamie L. Everman et autres

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Rhinovirus (HRV) Infection Drives Severe Wheezing Episodes in Toddlers: Viral Metagenomic Analysis in the WINDOWS Study

Elizabeth A. Secor, Katharine L. Hamlington, Jamie L. Everman, Katrina Diener et autres

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A step toward predicting recurrence in preschool-age severe wheeze

Katharine L. Hamlington, Nidhya Navanandan

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