Daniel J. Crona

Beyond Trial‐and‐Error: Integrating Pharmacogenomics and the 5Ms Framework to Optimize Psychiatric Prescribing in Older Veterans

Shaye A Kerper, Sara Jubas, Charles Austin, Daniel J. Crona et autres

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A Review of Population Pharmacokinetic Models and Dosing Algorithms Assessing the Influence of CYP3A5 Genotype and Other Clinical Covariates on Tacrolimus Pharmacokinetics

Riley M. Randolph, Sara Jubas, Li Gong, Raman Venkataramanan et autres

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Evaluating Day +90 Donor Chimerism as a Prognostic Marker of Clinical Outcomes Among Allogeneic Hematopoietic Cell Transplant Recipients Who Received Myeloablative Conditioning

Sara Jubas, Kieran Collins, Kendall Obara, Hsuan-Hui Liu et autres

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Abstract 3196: MPP8 inhibits PRKN signaling through interactions with SIRT1 and ZEB1 to promote bladder cancer proliferation and metastasis

Stephany Gonzalez Tineo, Ryan M. Kemper, Surya K. Tripathi, Daniel J. Crona

Abstract Background: Metastatic bladder cancer (mBC) remains incurable, and epigenetic dysregulation is associated with disease progression. We hypothesize that the H3K9me3 reader protein MPP8 complexes with class III histone deacetylase SIRT1 and transcription factor ZEB1 to drive proliferation and metastasis. Here, we …

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Letermovir Improves Real-World, 5-Year Overall Survival Among CMV Seropositive Allogeneic Hematopoietic Cell Transplant Recipients

Morgan Bizzell, Daniel J. Crona, Hailey Hirata, Jonathan Ptachcinski et autres

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Donor Chimerism at Day +90 Predicts Better Survival Outcomes Among Allogeneic Hematopoietic Cell Transplantation Recipients Receiving Myeloablative Conditioning

Sara Jubas, Kieran Collins, Hsuan-Hui Liu, Ryan M. Kemper et autres

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Assessment of Therapeutic Drug Monitoring and Generalizability of a Population PK Model for Busulfan Applied across Five Datasets

Min Chen, M. T. Vu Hai, Tyler Dunlap, Daniel J. Crona et autres

ABSTRACT Busulfan is commonly used in hematopoietic stem cell transplantation conditioning, with therapeutic drug monitoring (TDM) guiding dose adjustments to promote target exposure attainment. Published busulfan population pharmacokinetic (popPK) models vary in structure and covariates, and it is unclear how broadly applicable …

Synthesis and Evaluation of Novel 1,2,6-Thiadiazinone Kinase Inhibitors as Potent Inhibitors of Solid Tumors

Andreas S. Kalogirou, Chad Torrice, Panayiotis A. Koutentis, Gary L. Johnson et autres

A focused series of substituted 4H-1,2,6-thiadiazin-4-ones was designed and synthesized to probe the anti-cancer properties of this scaffold. Insights from previous kinase inhibitor programs were used to carefully select several different substitution patterns. Compounds were tested on bladder, prostate, pancreatic, breast, chordoma, …

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QUALITY OF LIFE, FATIGUE, AND DEPRESSION REMAIN UNCHANGED WITH TREATMENT FOR ADVANCED PROSTATE CANCER

Kailyn Lowder, Abrar Al Hammadi, Ayange S. Ayangeakaa, Sarah Blount et autres

PURPOSE: Cross-sectional studies suggest that men with advanced prostate cancer (PC) treated with androgen receptor pathway inhibitors (ARPI) have lower reported quality of life (QoL). However, the rate of decline in QoL as well as the extent to the decline during treatment …

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Assessing Physical Activity Levels In Advanced Prostate Cancer Survivors: Comparing Non-gravitational And Gravitational Cut-points

Abrar Al Hammadi, Aiden J. Chauntry, Mark Belio, Sarah Blount et autres

BACKGROUND: The literature on physical activity (PA) in advanced prostate cancer (PC) is mixed and methodologically heterogeneous, with much of it using non-gravitational cut points (e.g., average counts per minute; cpm). However, these cut points are influenced by study-specific factors such as …

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A First-in-Class Chemical-Induced Proximity System Achieves Dose-Dependent Control of Tumor Protein P53 Gene Activation in Preclinical Models of Gastric Cancer

Travis J. Nelson, Ryan M. Kemper, Anna M. Chiarella, Stephany Gonzalez Tineo et autres

High Resolution Image Download MS PowerPoint Slide The tumor protein P53 ( TP53 ) gene has long been studied in cancer research with genomic and epigenetic aberrations playing a driving role in cancer pathology, yet even after decades of work, only a …

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A Tacrolimus Population Pharmacokinetic Model for Adult Allogeneic Hematopoietic Cell Transplant Recipients Provides Clinical Opportunities for Precision Dosing

Tyler Dunlap, Jing Zhu, Daniel Weiner, Ryan M. Kemper et autres

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