Roberta Facchinetti

Palmitoylethanolamide and Luteolin in Brain Aging and Cognitive Decline: Biological Rationale and Current Evidence

Francesca Mancinetti, Virginia Boccardi, Marta Valenza, Martina Alunno et autres

Cognitive decline is closely associated with biological aging and with interconnected processes, including chronic low-grade inflammation, oxidative stress, mitochondrial dysfunction, and cellular senescence. Nutraceutical strategies capable of modulating several of these pathways may represent a complementary approach to supporting cognitive health. This …

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Correction: Neuroglia in the autistic brain: evidence from a preclinical model

Maria Rosanna Bronzuoli, Roberta Facchinetti, Davide Ingrassia, Michela Servadio et autres

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Editorial: Astrocytes and immunity: unveiling their role in pain and neurodegenerative disease progression

Alessandra Toti, Roberta Facchinetti, Sumonto Mitra, Giulia Magni

Astrocytes are now recognized as active regulators of central nervous system homeostasis and disease. Through their interactions with neurons, immune cells, endothelial cells, and peripheral signals, they shape neurotransmission, inflammatory responses, ionic balance, and blood-brain barrier (BBB) integrity. The articles collected in …

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Palmitoylethanolamide and Luteolin in Brain Aging and Cognitive Decline: Biological Rationale and Current Evidence

Francesca Mancinetti, Virginia Boccardi, Marta Valenza, Martina Alunno et autres

Cognitive decline is closely associated with biological aging and with interconnected processes, including chronic low-grade inflammation, oxidative stress, mitochondrial dysfunction, and cellular senescence. Nutraceutical strategies capable of modulating several of these pathways may represent a complementary approach to supporting cognitive health. This …

Endogenous Activation of mGlu5 Metabotropic Glutamate Receptors Is Required for Oligodendrocyte Maturation and Myelinogenesis in Mice

Roxana Paula Ginerete, Roberta Facchinetti, Alessia Ceccherelli, Giada Mascio et autres

mGlu5 metabotropic glutamate receptors are highly expressed and functional in early postnatal life, but their role in brain development remains to be elucidated. We now report that mGlu5−/− mice showed a large reduction in mRNA and protein levels of myelin-associated glycoprotein (MAG), …

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Microglial TDP-43 mediates myelin refinement and represses Tyrobp cryptic exon inclusion in mice

Anne‐Claire Compagnion, Andranik Ivanov, Anil Rana, Felipe Espinoza et autres

TDP-43 proteinopathy is a hallmark of neurodegenerative disorders such as amyotrophic lateral sclerosis and frontotemporal dementia where mislocalization of TDP-43 has been observed in neurons and glial cells. However, the role of TDP-43 in microglia and the consequences of its loss of …

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Ultramicronized palmitoylethanolamide restores astrocyte-neuron metabolic coupling and Klotho/FGF21 signaling in a triple-transgenic mouse model of Alzheimer’s disease

Roberta Facchinetti, Marta Valenza, Claudia Ciarla, Luca Steardo et autres

Alzheimer's disease (AD), a multifactorial neurodegenerative disorder, is characterized by metabolic deficiency, neuroinflammation, and synaptic impairment. Astrocyte-neuron metabolic coupling regulates cerebral energy homeostasis through key metabolites such as lactate, glutamate, and taurine. We investigated the therapeutic potential of ultramicronized-palmitoylethanolamide (um-PEA) in restoring …

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Corpus Analysis of News Discourse

Roberta Facchinetti

Abstract This paper addresses historical and contemporary news discourse from a Corpus Linguistics (CL) perspective and with English in focus. I first illustrate the main changes undergone by news discourse since its early development to the present time, particularly with reference to …

Ultramicronized palmitoylethanolamide restores astrocyte-neuron metabolic coupling and Klotho/FGF21 signaling in a triple-transgenic mouse model of Alzheimer’s disease

Roberta Facchinetti, Valenza Marta, C. Claudia, Luca Steardo et autres

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The (ever)changing face of news, with broadcast interviews in focus

Roberta Facchinetti

In this paper I intend to shed light on broadcast news interviews with a focus on the increasing role of video-mediated platforms. To do so, I first overview the rules of conduct journalists are required to follow, pondering on whether the shift …

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Molecular signatures of astrocytes and microglia maladaptive responses to acute stress are rescued by a single administration of ketamine in a rodent model of PTSD

Marta Valenza, Roberta Facchinetti, Carola Torazza, Claudia Ciarla et autres

Stress affects the brain and alters its neuroarchitecture and function; these changes can be severe and lead to psychiatric disorders. Recent evidence suggests that astrocytes and microglia play an essential role in the stress response by contributing to the maintenance of cerebral …

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Anti-GluA3 autoantibodies define a new sub-population of frontotemporal lobar degeneration patients with distinct neuropathological features

Maria Italia, Michela Salvadè, Filippo La Greca, Elisa Zianni et autres

Autoantibodies directed against the GluA3 subunit (anti-GluA3 hIgGs) of AMPA receptors have been identified in 20%-25% of patients with frontotemporal lobar degeneration (FTLD). Data from patients and in vitro/ex vivo pre-clinical studies indicate that anti-GluA3 hIgGs negatively affect glutamatergic neurotransmission. However, whether …

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