Lisa‐Catherine Rosenbaum

Topical BET PROTACs for locally restricted protein degradation in the lung

Martin Hemmerling, Jianming Liu, Antonio Piras, Rikard Pehrson et autres

Intratracheal administration of PROTAC 13 induced dose-dependent, local BRD4 degradation in the mouse lung, sparing BRD4 levels in the spleen.

nl, fi, se, jp, it, fr, es (code pays fourni par la source)

CCDC 2016640: Experimental Crystal Structure Determination

Lisa‐Catherine Rosenbaum, Maximilian Häfner, Tanja Gaich

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2016642: Experimental Crystal Structure Determination

Lisa‐Catherine Rosenbaum, Maximilian Häfner, Tanja Gaich

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2016641: Experimental Crystal Structure Determination

Lisa‐Catherine Rosenbaum, Maximilian Häfner, Tanja Gaich

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

Total Synthesis of the Diterpene Waihoensene

Lisa‐Catherine Rosenbaum, Maximilian Häfner, Tanja Gaich

A racemic and scalable enantioselective total synthesis of (+)-waihoensene was accomplished. (+)-Waihoensene belongs to the diterpene natural product family, and it features an angular triquinane substructure motif. Its tetracyclic [6.5.5.5]backbone is all-cis-fused, containing six contiguous stereocenters, four of which are quaternary. These …

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Total Synthesis of the Diterpene Waihoensene

Lisa‐Catherine Rosenbaum, Maximilian Häfner, Tanja Gaich

Abstract A racemic and scalable enantioselective total synthesis of (+)‐waihoensene was accomplished. (+)‐Waihoensene belongs to the diterpene natural product family, and it features an angular triquinane substructure motif. Its tetracyclic [6.5.5.5]backbone is all‐cis‐fused, containing six contiguous stereocenters, four of which are quaternary. …

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CCDC 1971352: Experimental Crystal Structure Determination

Larissa A. Casper, Steffen Oßwald, Patrick Anders, Lisa‐Catherine Rosenbaum et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

Extremely Electron‐Poor Bis(diarylmethylium)‐Substituted Ferrocenes and the First Peroxoferrocenophane

Larissa A. Casper, Steffen Oßwald, Patrick Anders, Lisa‐Catherine Rosenbaum et autres

We have prepared and studied extremely electron‐poor, deeply colored dicationic 1,1'‐bis(diarylmethylium)‐substituted ferrocenes [(η5‐C5H4‐CAr2)2Fe]2+ with various aryl substituents as their [B{C6H3(CF3)2‐3,5}4]– salts. Due to the strong acceptor substitution, the redox potential for the ferrocene‐based oxidation of the anisyl‐ or 2‐methylanisyl‐substituted congeners 1b2+ and …

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Light-switchable anchors on magnetized biomorphic microcarriers

Julian Opel, Lisa‐Catherine Rosenbaum, Julian Brunner, Anne Staiger et autres

Microcarriers with the ability to release and catch substances are highly desired metamaterials and difficult to obtain. Herein, we report a straightforward strategy to synthesize these materials by combining silica-biomorphs with mesocrystals. An easy access to microcarrier hulls with covalently bound spiropyrans …

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