Haoqing Gu

Blood Pressure Levels and Outcomes in Type 2 Diabetes

Siyu Wang, Kan Wang, Haoqing Gu, Junheng Zhang et autres

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Intensive blood pressure control and risks of cognitive outcomes in patients with new-onset orthostatic hypotension

Siyu Wang, Jingya Wang, Yueyue Wang, Xiaoli Xu et autres

BACKGROUND: Orthostatic hypotension (OH) increases the risk of dementia. Although intensive blood pressure (BP) lowering may have cognitive benefits regardless of baseline OH status, its effects in participants who develop OH during intervention remain unknown. METHODS: Participants of the Systolic Blood Pressure …

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Tumor-Derived Exosomal Fatty Acids Reprogram Neutrophils to Drive Neutrophil Extracellular Traps Formation and Lung Cancer Progression

Lulu Han, Yuxin Chen, Ruchen Wu, Juenze Chen et autres

Tumor-infiltrating neutrophils are increasingly recognized as key drivers of cancer progression, but the mechanisms that govern their protumoral reprogramming remain elusive. Here, we demonstrated that lung cancer-derived exosomes (LDEs) deliver free fatty acids into neutrophils, triggering lipid accumulation, fatty acid β-oxidation, and …

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Efficacy and safety of Atractylodes macrocephala-containing traditional Chinese medicine combined with neoadjuvant chemotherapy in the treatment of advanced gastric cancer: a systematic evaluation and meta-analysis

X. Niu, Haoqing Gu, Jingzhan Li, Jiaqian Zuo et autres

Background In China, Atractylodes-containing Chinese medicines are widely used as adjuvant therapy to neoadjuvant chemotherapy (NAC) in individuals diagnosed with advanced gastric cancer (AGC). Nevertheless, the findings concerning its effectiveness are still restricted. The aim from this research was to examine the …

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Identification of immune-related gene signature for predicting prognosis in uterine corpus endometrial carcinoma

Siyuan Song, Haoqing Gu, Jingzhan Li, Peipei Yang et autres

The objective of this study is to develop a gene signature related to the immune system that can be used to create personalized immunotherapy for Uterine Corpus Endometrial Carcinoma (UCEC). To classify the UCEC samples into different immune clusters, we utilized consensus …

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Pan-cancer analyses confirmed the cuproptosis-related gene LIPT1 as an immunotherapy predictor and prognostic biomarker

Peipei Yang, Li Ye, Wenjie Huang, Siyuan Song et autres

Abstract Recent studies have shown that Lipoyltransferase 1 (LIPT1) is a cuproptosis-key gene that plays a critical role in cancer progression, and therefore exploring the underlying mechanisms and biological functions of LIPT1 may provide potential therapeutic guidance for cancer treatment. Our study …

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