Shaun F. Morrison

Inhibition of the hypothalamic ventromedial periventricular area activates a dynorphin pathway-dependent thermoregulatory inversion in rats

Shaun F. Morrison, Georgina Cano, Shelby L. Hernan, Pierfrancesco Chiavetta et autres

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Inhibition of Anteroventral Periventricular Nucleus (AVPe) Unveils a Novel Central Circuit Controlling Thermoregulatory Inversion and a Torpor-Like State

Domenico Tupone, Shelby L. Hernan, Pierfrancesco Chiavetta, Shaun F. Morrison et autres

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Central circuit controlling thermoregulatory inversion and torpor-like state

Domenico Tupone, Shelby L. Hernan, Pierfrancesco Chiavetta, Shaun F. Morrison et autres

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503 Stimulation of the Paraventricular Nucleus Activates Brown Adipose Tissue via Local GABA Release: A Novel Target for the Treatment of Obesity

Dominic Aaron Siler, Clarissa M. D. Mota, Shaun F. Morrison, Kim J. Burchiel et autres

INTRODUCTION: Sympathetic activation of brown adipose tissue (BAT) has shown significant promise in preclinical studies to elicit long term weight loss and reversal of type 2 diabetes however it is inhibited in obese individuals. METHODS: Rats were anesthetized and monitored for body …

The neural pathway of the hyperthermic response to antagonists of the transient receptor potential vanilloid-1 channel

András Garami, Alexandre A. Steiner, Eszter Pákai, Samuel Penna Wanner et autres

We identified the neural pathway of the hyperthermic response to TRPV1 antagonists. We showed that hyperthermia induced by i.v. AMG0347, AMG 517, or AMG8163 did not occur in rats with abdominal sensory nerves desensitized by pretreatment with a low i.p. dose of …

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Physiology of thermoregulation: central and peripheral mechanisms

Nisha Charkoudian, Shaun F. Morrison

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Contributors

Daniela Accorsi‐Mendonça, David J. Adams, Andrew M. Allen, Marlies Alvarenga et autres

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Thermoregulation in mice: The road to understanding torpor hypothermia and the shortcomings of a circuit for generating fever

Shaun F. Morrison, Kazuhiro Nakamura, Domenico Tupone

Comment on: Machado NLS, Saper CB. Genetic identification of preoptic neurons that regulate body temperature in mice. Temperature. 2022;9(1):14-22. DOI:10.1080/23328940.2021.1993734In their review,...

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Central sympathetic network for thermoregulatory responses to psychological stress

Kazuhiro Nakamura, Shaun F. Morrison

In mammals, many types of psychological stressors elicit a variety of sympathoexcitatory responses paralleling the classic fight-or-flight response to a threat to survival, including increased body temperature via brown adipose tissue thermogenesis and cutaneous vasoconstriction, and increased skeletal muscle blood flow via …

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Dopaminergic input from the posterior hypothalamus to the raphe pallidus area inhibits brown adipose tissue thermogenesis

Ellen Paula Santos da Conceição, Clarissa M. D. Mota, Edward Veytsman, Shaun F. Morrison et autres

Systemic administration of dopamine (DA) receptor agonists leads to falls in body temperature. However, the central thermoregulatory pathways modulated by DA have not been fully elucidated. Here we identified a source and site of action contributing to DA’s hypothermic action by inhibition …

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Activation of Transient Receptor Potential Vanilloid 1 Channels in the Nucleus of the Solitary Tract and Activation of Dynorphin Input to the Median Preoptic Nucleus Contribute to Impaired BAT Thermogenesis in Diet-Induced Obesity

Ellen Paula Santos da Conceição, Christian A. Reynolds, Shaun F. Morrison, Christopher J. Madden

The impairment of cold-evoked activation of brown adipose tissue (BAT) in rats fed a high-fat diet (HFD) requires the activity of a vagal afferent to the medial nucleus of the solitary tract (mNTS). We determined the role of transient receptor potential vanilloid …

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Body Temperature Regulation

Shaun F. Morrison

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